[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338427-105":59,"doc-detail-338427-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","understanding-the-anticancer-properties-of-honey-review","Understanding the Anticancer Properties of Honey - Review","","Uncontrolled cell growth with malignant potential defines cancer and drives major global mortality. Cancer chemotherapy and related cytotoxic drugs can produce multiple adverse effects and may be limited by cost and availability, particularly in developing regions, alongside other gaps in current care. Emerging research suggests honey is not cytotoxic to normal cells yet shows selective, pronounced cytotoxicity toward tumor cells and may influence several cell signaling pathways, though the precise mechanism remains incompletely resolved.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/understanding-the-anticancer-properties-of-honey-review/338427/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/understanding-the-anticancer-properties-of-honey-review/338427.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are complementary and alternative medicine approaches like honey being studied for cancer?","Question",{"text":113,"@type":114},"Cancer therapies such as surgery, chemotherapy, and radiation have drawbacks and cytotoxic drugs can be linked to unfavorable side effects and limited affordability/access. As a result, attention has grown toward complementary and alternative medicine, including products like honey, to explore potential benefits with fewer disadvantages.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What evidence is described regarding honey’s effects on cancer cells?",{"text":118,"@type":114},"The article states that honey is not cytotoxic to normal cells but is highly and particularly cytotoxic to tumor cells. It also reports that honey affects multiple cell signaling pathways, indicating potential anticancer activity.",{"name":120,"@type":111,"acceptedAnswer":121},"What is still unknown about honey’s anticancer action?",{"text":122,"@type":114},"Although research suggests honey influences cell signaling pathways and shows selective cytotoxicity, the precise method or mechanism is not completely known at the time of the review.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},338427,1790106307,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Review  \nUnderstanding the Anticancer Properties of Honey Simona Martinotti , Gregorio Bonsignore  and Elia Ranzato *  \nCitation: Martinotti, S.; Bonsignore, G.; Ranzato, E. Understanding the Anticancer Properties of Honey. Int. J. Mol. Sci. 2024, 25, 11724. [https://](https://)[ ](https://)[doi.org/10.3390/ijms252111724](doi.org/10.3390/ijms252111724)  \nAcademic Editors: Josef Jampilek and Giovanni Pallio  \nReceived: 25 September 2024  \nRevised: 22 October 2024  \nAccepted: 30 October 2024  \nPublished: 31 October 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDipartimento di Scienze e Innovazione Tecnologica (DiSIT), University of Piemonte Orientale, 15121 Alessandria,  \nItaly; [simona.martinotti@uniupo.it](simona.martinotti@uniupo.it) (S.M.); [gregorio.bonsignore@uniupo.it](gregorio.bonsignore@uniupo.it) (G.B.)  \n* Correspondence: [elia.ranzato@uniupo.it](elia.ranzato@uniupo.it); Tel.: +39-0131360260  \nAbstract: Uncontrolled cell growth that possesses the capacity to exhibit malignant behavior is referred to as cancer. The cytotoxic drugs used to fight cancer are associated with several adverse effects and are not always readily available or affordable, especially in developing countries. These issues are in addition to the shortcomings of the current cancer treatment regimen. According to growing research, honey is not cytotoxic to normal cells but is highly and particularly cytotoxic to tumor cells, suggesting that honey may display anticancer effects. Research has shown that honey affects a number of cell signaling pathways; however, at the moment, the precise method is not completely known.  \nKeywords: anti-proliferative effects; cancer cells; honey; oxidative stress  \n1. Introduction  \nCancer is the term for unchecked cell development that has the potential to become malignant. It ranks among the world’s main causes of death [1] . Over 35 million new cancer cases are predicted in 2050, a 77% increase from the estimated 20 million cases in 2022 [2] .  \nThis rising prevalence can be attributed to several factors, such as an aging population, the adoption of a Western lifestyle in many developing countries, increased awareness, and improved cancer screening and diagnosis.  \nIn addition to the shortcomings of the current cancer treatment regimen, which consists of surgery, chemotherapy, and radiation therapy, the use of cytotoxic drugs is linked toa number of unfavorable side effects, and these drugs are not always readily affordable or accessible, particularly in developing nations [3] . Because of this, a sizable segment of the populace favors using complementary and alternative medicine (CAM) . Compared to synthetic or conventional medications, CAM offers several benefits, including less side effects, availability, and price [4,5] . Growing public interest in the use of CAM can be linked to the corpus of research showing some benefits of CAM. Conventional medicine is based on techniques that have been shown via well-planned trials and research to be secure and efficient. However, a lot of CAM therapies still lack reliable research upon which to make well-informed choices. Many CAM treatments have unproven risks and potential benefits.  \nIn general, CAM refers to a variety of therapeutic modalities (medical goods and procedures) that do not form an essential part of mainstream medicine. These modalities may include nutritional supplements, herbal treatments, naturally derived goods, and even lifestyle modifications [4] .  \nCancer patients now use and are more aware of complementary and alternative medicine [6] . One such product that has grown to be a crucial part of complementary and alternative medicine is ","cbCaipFF5YHEGOY3","https://ap.wps.com/l/cbCaipFF5YHEGOY3","pdf",614909,12,"English","# Abstract\n# Keywords\n# Introduction\n# Honey Composition","[{\"question\":\"Why are complementary and alternative medicine approaches like honey being studied for cancer?\",\"answer\":\"Cancer therapies such as surgery, chemotherapy, and radiation have drawbacks and cytotoxic drugs can be linked to unfavorable side effects and limited affordability/access. As a result, attention has grown toward complementary and alternative medicine, including products like honey, to explore potential benefits with fewer disadvantages.\"},{\"question\":\"What evidence is described regarding honey’s effects on cancer cells?\",\"answer\":\"The article states that honey is not cytotoxic to normal cells but is highly and particularly cytotoxic to tumor cells. It also reports that honey affects multiple cell signaling pathways, indicating potential anticancer activity.\"},{\"question\":\"What is still unknown about honey’s anticancer action?\",\"answer\":\"Although research suggests honey influences cell signaling pathways and shows selective cytotoxicity, the precise method or mechanism is not completely known at the time of the review.\"}]","Understanding the Anticancer Properties of Honey - Review | PDF",1790023587]