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This study evaluates whether consistent TAPS use improves underlying tremor severity over longer follow-up. A retrospective multicenter PROSPECT trial analysis compares baseline pre-stimulation tremor measures with pre-stimulation assessments at 1 and 3 months using BF-ADL and TETRAS scales, defining responders by task-level improvement.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/underlying-tremor-improvement-with-consistent-use-of-transcutaneous-afferent-patterned-stimulation-in-patients-with-essential-tremor/461219/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/underlying-tremor-improvement-with-consistent-use-of-transcutaneous-afferent-patterned-stimulation-in-patients-with-essential-tremor/461219.png","ImageObject",300,407,{"name":92,"@type":93},"eBook King","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is TAPS and how is it delivered for essential tremor?","Question",{"text":112,"@type":113},"TAPS is a non-invasive, wrist-worn neurostimulation therapy that delivers alternating bursts of stimulation pulses to the median and radial nerves. Pulse frequency is calibrated to each patient’s tremor frequency.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the study assess underlying tremor improvement?",{"text":117,"@type":113},"Underlying improvement was assessed by comparing pre-stimulation tremor severity at baseline with pre-stimulation severity at 1- and 3-month follow-up visits. Measurements used BF-ADL and TETRAS scales.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings after consistent TAPS use?",{"text":121,"@type":113},"BF-ADL scores improved significantly at 1 and 3 months, and TETRAS scores also showed significant improvements at both time points. Over 80% of patients met responder criteria at both follow-up visits, including patients using TAPS about once daily.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461219,1790961608,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962088006270,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Underlying Tremor Improvement with Consistent Use of Transcutaneous Afferent Patterned Stimulation in Patients with Essential Tremor  \nSTUART H. ISAACSON  HOLLY A. SHILL   \nELIZABETH PECKHAM FERNANDO L. PAGAN  \nWINONA TSE  PRAVIN KHEMANI   \nMELITA T. PETROSSIAN  JESSICA TATE  \nMICHAEL J. SOILEAU  LAN LUO   \nMARK LEW WILLIAM ONDO   \nCAMERON DIETIKER  MARK HALLETT   \nNIJEE LUTHRA  CHIAHAO LU   \nPINKY AGARWAL  KATHRYN H. ROSENBLUTH   \nROHIT DHALL  SCOTT L. DELP   \nJOHN MORGAN RAJESH PAHWA   \nEJAZ A. SHAMIM   \n*Author affiliations can be found in the back matter of this article  \nABSTRACT  \nBackground: Transcutaneous afferent patterned stimulation (TAPS) is a non-invasive, wrist-worn neurostimulation therapy that has demonstrated acute and short-term lasting tremor reduction in patients with essential tremor (ET) . However, the longer-term improvement in underlying tremor severity from consistent use of TAPS has not been fully explored.  \nMethods: We conducted a retrospective analysis of the multicenter PROSPECT trial, which evaluated twice-daily TAPS use over three months in patients with ET. Underlying tremor improvement was assessed by comparing pre-stimulation tremor severity at baseline with pre-stimulation tremor severity at 1-and 3-month follow-up visits. Tremor severity was measured using the Bain & Findley Activities of Daily Living (BF-ADL) scale and the Tremor Research Group’s Essential Tremor Rating Assessment Scale (TETRAS) . Responders were defined as patients demonstrating at least a 1-point improvement on any qualifying task.  \nNEW OBSERVATIONS LETTER  \nCORRESPONDING AUTHOR:  \nScott L. Delp, PhD  \nS-321 Clark Center, Stanford University, Stanford CA, 94305, USA  \n[delp@stanford.edu](delp@stanford.edu)  \nKEYWORDS:  \ntremor; neuromodulation; transcutaneous afferent patterned stimulation; underlying tremor improvement  \nTO CITE THIS ARTICLE:  \nIsaacson SH, Peckham E, Tse W, Petrossian MT, Soileau MJ, Lew M, Dietiker C, Luthra N, Agarwal P, Dhall R, Morgan J, Shamim EA, Shill HA, Pagan FL, Khemani P, Tate J, Luo L, Ondo W, Hallett M, Lu C, Rosenbluth KH, Delp SL, Pahwa R. Underlying Tremor Improvement with Consistent Use of Transcutaneous Afferent Patterned Stimulation in Patients with Essential Tremor. Tremor and Other Hyperkinetic Movements. 2026; 16(1):  \n1, pp. 1–7. DOI: [https://doi](https://doi). org/10.5334/tohm.1091  \nResults: Among 192 patients with available data, pre-stimulation BF-ADL scores improved significantly by 2.0 points at 1 month and 2.7 points at 3 months compared with baseline (p \u003C 0.001) . Pre-stimulation TETRAS scores also showed significant improvements at both time points (p \u003C 0.001) . Measurements at 1 and 3 months were made an average of 16.2 hours after the prior stimulation session. Over 80% of patients met responder criteria for underlying tremor improvement on BF-ADL and TETRAS at both follow-up visits. Improvements were observed even among patients using TAPS approximately once daily.  \nConclusions: Consistent use of TAPS was associated with significant improvement in underlying tremor severity in patients with essential tremor. These findings suggest that regular TAPS use may confer sustained therapeutic benefit.  \nDecades of bioengineering development, neurostimulation advances, and neuroscience research has led to the clinical development of non-invasive, individualized, wrist-based neurostimulation as a safe and effective therapy to reduce tremor that impairs daily activities in people living with essential tremor (ET) . Non-invasive peripheral electrical neurostimulation has demonstrated safety and improved clinical outcomes in four randomized clinical trials (N = 23 [1], N = 77 [2], N = 276 [3], N = 125 [4]), two open-label studies (N = 205 [5], N = 17 [6]), analyses of real-world usage (N = 321 [7], N = 1,223 [8]), health care economic data (N = 459  [9]), and mechanistic studies  [10, 11] .  \nTranscutaneous afferent patterned stimulation (TAPS) therapy is the most widely studie","cbCaicd9gMijmTM1","https://ap.wps.com/l/cbCaicd9gMijmTM1","pdf",1440853,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Study Context and Rationale\n## Device and therapy background\n## Definitions of tremor benefit duration","[{\"question\":\"What is TAPS and how is it delivered for essential tremor?\",\"answer\":\"TAPS is a non-invasive, wrist-worn neurostimulation therapy that delivers alternating bursts of stimulation pulses to the median and radial nerves. Pulse frequency is calibrated to each patient’s tremor frequency.\"},{\"question\":\"How did the study assess underlying tremor improvement?\",\"answer\":\"Underlying improvement was assessed by comparing pre-stimulation tremor severity at baseline with pre-stimulation severity at 1- and 3-month follow-up visits. Measurements used BF-ADL and TETRAS scales.\"},{\"question\":\"What were the key findings after consistent TAPS use?\",\"answer\":\"BF-ADL scores improved significantly at 1 and 3 months, and TETRAS scores also showed significant improvements at both time points. Over 80% of patients met responder criteria at both follow-up visits, including patients using TAPS about once daily.\"}]","Underlying Tremor Improvement with Consistent Use of Transcutaneous Afferent Patterned Stimulation in Patients with Essential Tremor | PDF",1790760970,18]