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Searches covered systematic reviews and primary diagnostic accuracy or detection-rate studies up to December 2021, with AMSTAR2 and JBI tools used for appraisal. 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The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ([https://creativecommons.org/licenses/by-nc-nd/4.0/](https://creativecommons.org/licenses/by-nc-nd/4.0/))  \nGeorg Thieme Verlag KG, Rüdigerstraße 14, 70469 Stuttgart, Germany  \nCorresponding author  \nNicola J Adderley, University of Birmingham, Institute of Applied Health Research, Birmingham, United Kingdom of Great Britain and Northern Ireland [n.j.adderley@bham.ac.uk](n.j.adderley@bham.ac.uk)  \n Additional material is available at [https://doi.org/10.1055/a-2117-8621](https://doi.org/10.1055/a-2117-8621)  \nABSTRACT  \nBackground and study aims Upper gastrointestinal (UGI) endoscopy lacks established quality indicators. We conducted an umbrella systematic review of potential quality indicators for the detection of UGI cancer and dysplasia. Methods Bibliographic databases were searched up to December 2021 for systematic reviews and primary studies. Studies reporting diagnostic accuracy, detection rates orthe association of endoscopy or endoscopist-related factors with UGI cancer or dysplasia detection were included. AMSTAR2 and JBI checklists were used to assess systematic review and primary study quality. Clinical heterogeneity precluded meta-analysis and findings are summarized narratively.  \nKamran Umair et al. Umbrella systematic review… Endosc Int Open 2023; 11: E835–E848 | © 2023. The Author(s) . E835  \nResults Eight systematic reviews and nine primary studies were included. Image enhancement, especially narrow band imaging, had h","cbCaihXdiTHLTLBf","https://ap.wps.com/l/cbCaihXdiTHLTLBf","pdf",1565630,14,"English","# Abstract\n## Background and study aims\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What problem does the umbrella systematic review address?\",\"answer\":\"Upper gastrointestinal endoscopy lacks established quality indicators for detecting cancer and dysplasia. The review identifies potential indicators that could improve detection.\"},{\"question\":\"How were studies identified and quality assessed?\",\"answer\":\"Bibliographic databases were searched up to December 2021 for systematic reviews and primary studies. AMSTAR2 was used for systematic reviews and JBI checklists for primary studies.\"},{\"question\":\"What key indicators showed higher diagnostic performance or detection?\",\"answer\":\"Image enhancement, especially narrow band imaging, showed high diagnostic accuracy. Longer examination times, higher endoscopist biopsy rates, and propofol sedation were associated with increased detection in included studies.\"}]","Umbrella systematic review of potential quality indicators for the detection of dysplasia and cancer at upper gastrointestinal endoscopy - Abstract and key findings | PDF",1790273038,35]