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Cancer detection and several comorbidity-related findings showed no statistically significant differences, while transperineal biopsy reduced complications, post-procedure pain, and negative emotional scores and required longer puncture time.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/ultrasound-guided-transperineal-versus-transrectal-prostate-aspiration-biopsy-in-diagnosing-prostate-cancer-an-observational-comparison-study/364011/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/ultrasound-guided-transperineal-versus-transrectal-prostate-aspiration-biopsy-in-diagnosing-prostate-cancer-an-observational-comparison-study/364011.png","ImageObject",300,407,{"name":42,"@type":43},"dhado","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How many patients were included, and how were they divided into groups?","Question",{"text":63,"@type":64},"The study retrospectively analyzed 150 patients who underwent prostate biopsy between February 2020 and August 2024. Patients were divided into a transperineal group (n=62) and a transrectal group (n=88) based on the puncture method.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Were prostate cancer detection rates significantly different between transperineal and transrectal biopsy?",{"text":68,"@type":64},"No. The detection rates were 51.61% for transperineal biopsy versus 43.18% for transrectal biopsy, without a statistically significant difference.",{"name":70,"@type":61,"acceptedAnswer":71},"What advantages did transperineal biopsy show over transrectal biopsy?",{"text":72,"@type":64},"Transperineal biopsy required longer puncture time but led to fewer overall complications, lower post-procedure pain scores (VAS), and lower anxiety (HAMA) and depression scores (HAMD) compared with transrectal biopsy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},364011,1790780620,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},5909893218464,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","ORIGINAL ARTICLE   \nUltrasound-Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer An Observational Comparison Study  \nYue Cao, BM, Hong Zhu, BM, Junwei Wu, BM   \nArticle includes CME test  \nReceived July 31, 2025, from the Department of Ultrasound, Changxing County People’s Hospital, Huzhou, China (Y.C., H.Z., J.W.). Manuscript accepted for publication March 30, 2026.  \nYue Cao and Hong Zhu contributed equally to this work.  \nThe authors declare that there is no acknowledgment and competing interest associated with the manuscript.  \nAddress correspondence to Junwei Wu, BM, Department of Ultrasound, Changxing County People’s Hospital, No. 66, Taihu Middle Road, Zhicheng Sub-district, Changxing County, Huzhou City 313100, Zhejiang Province, China.  \n[E-mail:](E-mail: zjyyhr2016@163.com)[ zjyyhr2016@163.com](E-mail: zjyyhr2016@163.com)  \nAbbreviations  \nHAMA, Hamilton Anxiety Scale; HAMD, Hamilton Depression Scale; PSA, prostate-specific antigen; PSAD, prostatespecific antigen density; PTBx, transperineal puncture biopsy; TRBx, transrectal prostate biopsy; VAS, Visual Analogue Scale  \ndoi:10.1002/jum.70255  \nThis is an open access article under the terms of the  \nCreative Commons Attribution-NonCommercial  \nLicense, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.   \nBackground—Ultrasound-guided prostate biopsy is the standard method for the diagnosis of prostate cancer. However, the effect of the optimal puncture approach on diagnostic yield and patient outcomes remains controversial.  \nObjective—To compare the diagnostic effectiveness and clinical outcomes of ultrasound-guided transperineal versus transrectal prostate aspiration biopsy inpatients suspected of prostate cancer.  \nMethods—A retrospective analysis was conducted on 150 patients who underwent prostate biopsy at our hospital between February 2020 and August 2024. Patients were divided into transperineal (n = 62) and transrectal (n = 88) groups. Key outcomes including cancer detection rate, complications, pain (VAS), and negative emotions were compared, with p \u003C .05 indicating a statistically significant difference.  \nResults—No significant difference was found between the transperineal and transrectal groups in the detection rates of prostate cancer (51.61% versus 43.18%), chronic prostatitis (12.90% versus 18.18%), or benign prostatic hyperplasia (35.48% versus 38.64%) . Transperineal biopsy required longer puncture time (22 .92 􀀁 2.02 min versus 19 .70 􀀁 1.93 min), but resulted in fewer overall complications (20.97% versus 38.64%), lower post-procedure pain scores (VAS: 2.82 􀀁 1.13 versus 3.68 􀀁 1.14), and lower anxiety (HAMA: 10.34 􀀁 1.29 versus 12.55 􀀁 1.44) and depression scores (HAMD: 10.33 􀀁 1.68 versus 12.90 􀀁 1.38) .  \nConclusion—Both ultrasound-guided transperineal and transrectal prostate biopsies are effective diagnostic methods for prostate cancer. Transperineal biopsy offers advantages in reducing postoperative complications, pain, and negative emotional responses, supporting its preferential use in selected patients.  \nKey Words—complications; negative emotions; pain; prostate cancer; transperineal puncture; transrectal puncture  \nP rostate cancer is one of the most common malignant tumors  \nof the male genitourinary system, and its incidence  \ncontinues to rise globally, especially in older men. 1,2 As early symptoms of prostate cancer are not obvious, timely and effective diagnostic methods are crucial for improving patients’quality of life and prolonging their survival period.3,4 The gold  \n© 2026 The Author(s) . Journal of Ultrasound in Medicine published by Wiley Periodicals LLC on behalf of American Institute of Ultrasound in Medicine. | J Ultrasound Med 2026; 45:2001–[2009](2009 | 0278-4297 | www.aium.org)[ |](2009 | 0278-4297 | www.aium.org)[ 0278-4297](2009 | 0278-4297 | www.aium.org)[ |](2009 | 0278-429","cbCaivQg1E2QHKfZ","https://ap.wps.com/l/cbCaivQg1E2QHKfZ","pdf",394119,"English","# Background\n# Objective\n# Methods\n# Results\n# Conclusion","[{\"question\":\"How many patients were included, and how were they divided into groups?\",\"answer\":\"The study retrospectively analyzed 150 patients who underwent prostate biopsy between February 2020 and August 2024. Patients were divided into a transperineal group (n=62) and a transrectal group (n=88) based on the puncture method.\"},{\"question\":\"Were prostate cancer detection rates significantly different between transperineal and transrectal biopsy?\",\"answer\":\"No. The detection rates were 51.61% for transperineal biopsy versus 43.18% for transrectal biopsy, without a statistically significant difference.\"},{\"question\":\"What advantages did transperineal biopsy show over transrectal biopsy?\",\"answer\":\"Transperineal biopsy required longer puncture time but led to fewer overall complications, lower post-procedure pain scores (VAS), and lower anxiety (HAMA) and depression scores (HAMD) compared with transrectal biopsy.\"}]","Ultrasound-Guided Transperineal Versus Transrectal Prostate Aspiration Biopsy in Diagnosing Prostate Cancer - An Observational Comparison Study | PDF",1790155089,23]