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The document defines scope, background, and linked pre-, analytical, and post-analytical laboratory processes, and describes referral pathways to reference laboratories. 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UK SMIs are developed, reviewed and revised by various working groups which are overseen by a steering committee.  \nThe contributions of many individuals in clinical, specialist and reference laboratories who have provided information and comments during the development of this document are acknowledged. We are grateful to the medical editors for editing the medical content.  \nUK SMIs are produced in association with:  \nDisplayed logos correct as of December 2024  \nContents  \nAcknowledgments ....................................................................................................................2  \nContents ....................................................................................................................................3  \nAmendment table......................................................................................................................4  \n1 General information ......................................................................................................6  \n2 Scientific information ...................................................................................................6  \n3 Scope of document .......................................................................................................6  \n4 Background ...................................................................................................................7  \n5 Pre laboratory processes (pre analytical stage) ......................................................25  \n6 Laboratory processes (analytical stage) ...................................................................30  \n7 Post laboratory processes (post analytical stage) ..................................................39  \n8 Referral to reference laboratories..............................................................................40  \n9 Auditable outcome measures ....................................................................................41  \n10 Public health responsibilities of diagnostic laboratories........................................42  \nAppendix A: Critical control points in blood culture investigation ..................................43  \nAppendix B: Recommended audit standards ......................................................................45  \nReferences ..............................................................................................................................48  \nAmendment table  \nEach UK SMI document has an individual record of amendments. The amendments are listed on this page. The amendment [history is available from](history is available from standards@ukhsa.gov.uk)[ ](history is available from standards@ukhsa.gov.uk)[standards@ukhsa.gov.uk](history is available from standards@ukhsa.gov.uk).  \nAny alterations to this document should be controlled in accordance with the local document control process.  \n\n| Amendment number/date | 1/24.04.25 |\n| --- | --- |\n| Issue number discarded | 1 |\n| Insert issue number | 1.1 |\n| Section(s) involved | Amendment |\n| Whole document. | This is an administrative point change.\u003Cbr>The content of this UK SMI document has not changed.\u003Cbr>The last scientific and clinical review was conducted on 31.01.2023.\u003Cbr>Hyperlinks throughout document updated to Royal College of Pathologists website.\u003Cbr>Public Health England replaced with UK Health Security Agency throughout the document,\u003Cbr>including the updated Royal Coat of Arms Partner organisation logos updated.\u003Cbr>Broken links to devolved administrations replaced. References to NICE accreditation removed.\u003Cbr>Scope and Purpose replaced with General and Scientific information to align ","cbCaitDULUpsq042","https://ap.wps.com/l/cbCaitDULUpsq042","pdf",991905,58,"English","# Acknowledgments\n# Amendment table\n# 1 General information\n# 2 Scientific information\n# 3 Scope of document\n## 3.1 Scope and purpose\n# 4 Background\n# 5 Pre laboratory processes (pre analytical stage)\n# 6 Laboratory processes (analytical stage)\n# 7 Post laboratory processes (post analytical stage)\n# 8 Referral to reference laboratories\n# 9 Auditable outcome measures\n# 10 Public health responsibilities of diagnostic laboratories\n# Appendix A: Critical control points in blood culture investigation\n# Appendix B: Recommended audit standards\n# References","[{\"question\":\"What kinds of infections does this UK SMI cover?\",\"answer\":\"It covers initial investigations for sepsis and systemic or disseminated infections caused by bacteria, viruses, or fungi.\"},{\"question\":\"What does this document explicitly not address?\",\"answer\":\"It does not address detection of parasites, Mycobacterium species, or viral load testing, and it does not list specific details of kits or platforms.\"},{\"question\":\"How are laboratory processes organized in the document?\",\"answer\":\"Processes are structured across pre laboratory (pre-analytical), laboratory (analytical), and post laboratory (post-analytical) stages, with referral to reference laboratories and auditable outcome measures.\"}]","UK Standards for Microbiology Investigations - Sepsis and systemic or disseminated infections - Issue 1.1 | PDF",1790755003,146]