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It covers who may benefit from daily or on-demand PrEP dosing, risks such as side effects, kidney and bone monitoring, and the conditions that can affect HIV drug resistance. 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When taken correctly, it greatly reduces the risk of HIV sexual transmission by using a combination pill containing tenofovir DF (TDF) and emtricitabine (FTC).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Who might benefit from taking PrEP in the UK?",{"text":117,"@type":113},"HIV-negative people who don’t always use condoms may benefit. The guide highlights other higher-risk factors such as a recent STI, recent need for PEP, chemsex-related recreational drug use, or difficulties with adherence in an HIV-positive partner.",{"name":119,"@type":110,"acceptedAnswer":120},"What monitoring and side effect information does the guide cover?",{"text":121,"@type":113},"Most people do not experience side effects, but mild nausea, diarrhoea, bloating, and headache may occur in the first month and then usually stop. 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Cover graphic: [iwantPrEPnow.co.uk. Thanks](iwantPrEPnow.co.uk. Thanks) to MAC AIDS Fund and the Monument Trust for financial support.  \nISSN 2398-6409 (i-Base, London, 3rd edition, September 2017)  \n2 September 2017  \nIntroduction  \nThis booklet is a guide to PrEP in the UK.  \nIt was first written to support people who were buying PrEP online. This edition is also for people who are prescribed PrEP or are part of a research study.  \nPrEP currently refers to a combination pill containing tenofovir DF (TDF) and emtricitabine (FTC) . When taken correctly, PrEP greatly reduces the risk of HIV sexual transmission.  \nAccess to PrEP in the UK  \nThere have been several developments since the previous edition of this guide.  \n• NHS Scotland now provides PrEP. For more details [see: www.prep.scot](see: www.prep.scot)  \n• NHS England does not currently provide PrEP. Instead roughly 10,000 people can get PrEP in the PrEP IMPACT trial. IMPACT starts in September 2017 and will run for three years, but the study might enrol quickly.  \n• NHS Wales are now running a similar study called PrEPARED that currently has no cap on enrolment.  \n• PrEP is not currently available in Northern Ireland.  \n• The DISCOVER study (already enrolled) is comparing current PrEP to a newer version.  \n• Many people are likely to continue to buy generic PrEP using online pharmacies.  \nSeptember 2017 3  \nBackground  \nWhat is PrEP?  \nPrEP stands for pre-exposure prophylaxis. PrEP is taken before sex, so it is pre-exposure. Prophylaxis means to prevent infection. So HIV negative people can use PrEP to prevent them from becoming HIV positive.  \nCurrently, PrEP uses oral tablets that include two drugs: both tenofovir DF (TDF) and emtricitabine (FTC) . The main brand name for this is Truvada, but generic (non-branded) versions are also available.  \nBoth TDF and FTC have been widely used to treat HIV. PrEP was approved in the US in 2012 and in Europe in 2016.  \nWho would benefit from taking PrEP?  \nIf you are HIV negative and don’t always use condoms, then PrEP could reduce your risk of HIV.  \nOther factors related to a higher risk of HIV include:  \n• A recent STI (especially rectal infection or syphilis) .  \n• Recent need for PEP (post-exposure prophylaxis) .  \n• Using recreational drugs used for chemsex (crystal meth, mephedrone and GHB) .  \n• If your HIV positive partner is finding it difficult to be adherent to their HIV meds.  \nPlease speak to your doctor or nurse about how these risks affect you.  \n4 September 2017  \nIs there anyone who should not take PrEP?  \nPrEP should NOT be used:  \n• By people who are HIV positive.  \nPrEP is usually not needed if:  \n• The negative person only has HIV positive partners who are on ART with undetectable viral load. An undetectable viral load means that an HIV positive person is not infectious.  \n• If you are happy and able to always use condoms.  \nHow well does PrEP work?  \nPrEP is highly effective at reducing the risk of HIV infection. PrEP works extremely well if taken correctly.  \nGlobally, out of tens of thousands of people taking PrEP, only three HIV infections have so far been reported from when people were actually taking PrEP. Of these, two cases were due to drug ","cbCaivexAJMXmuSG","https://ap.wps.com/l/cbCaivexAJMXmuSG","pdf",872814,24,"English","# Introduction\n## Access to PrEP in the UK\n## Background\n## PrEP for women\n## PrEP for trans and non binary people\n## Buying PrEP online\n## Before you start\n## Routine care if you have already started PrEP\n## How to take PrEP\n## Daily PrEP: for both anal and vaginal sex\n## On-demand dosing: only for anal sex\n## Examples for on-demand dosing\n## Other tips on how to take PrEP\n## Credits and further information","[{\"question\":\"What is PrEP and how does it prevent HIV?\",\"answer\":\"PrEP (pre-exposure prophylaxis) is taken before sex to prevent infection. When taken correctly, it greatly reduces the risk of HIV sexual transmission by using a combination pill containing tenofovir DF (TDF) and emtricitabine (FTC).\"},{\"question\":\"Who might benefit from taking PrEP in the UK?\",\"answer\":\"HIV-negative people who don’t always use condoms may benefit. The guide highlights other higher-risk factors such as a recent STI, recent need for PEP, chemsex-related recreational drug use, or difficulties with adherence in an HIV-positive partner.\"},{\"question\":\"What monitoring and side effect information does the guide cover?\",\"answer\":\"Most people do not experience side effects, but mild nausea, diarrhoea, bloating, and headache may occur in the first month and then usually stop. Less commonly, PrEP can affect kidney function and/or bone health, so monitoring blood tests are used before and during treatment.\"}]","UK guide to PrEP - September 2017 | PDF",1790516313]