[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-401339-105":59,"doc-detail-401339-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","uk-guide-to-prep-13th-edition-updated-guidance-for-november-2025","UK guide to PrEP - 13th edition - Updated guidance for November 2025","","UK guide to PrEP provides practical guidance for people seeking HIV pre-exposure prophylaxis in the UK, aligned with the 2025 PrEP guidelines. It explains what PrEP is, who may benefit, how oral and injectable options work, and how PrEP supports infection prevention when taken correctly. The guide covers start and stop strategies, daily and event-based dosing (including 2:1:1 and 2:7), expected side effects, monitoring, and rare issues such as suspected missed infections and drug resistance.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/uk-guide-to-prep-13th-edition-updated-guidance-for-november-2025/401339/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/uk-guide-to-prep-13th-edition-updated-guidance-for-november-2025/401339.png","ImageObject",300,407,{"name":92,"@type":93},"EvelynWrites","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-27",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does PrEP stand for and what is its purpose?","Question",{"text":112,"@type":113},"PrEP stands for Pre-Exposure Prophylaxis. It is taken before sex to help prevent HIV infection and it also needs to be taken afterwards too.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Who can access PrEP in the UK under the 2025 guidelines?",{"text":117,"@type":113},"The 2025 guidelines state that anyone who is HIV negative and could benefit from PrEP should be able to access it, including people with recent STI, PEP use, chemsex, or partners with relevant risks.",{"name":119,"@type":110,"acceptedAnswer":120},"How does event-based PrEP dosing work?",{"text":121,"@type":113},"Event-based PrEP can use either 2:1:1 or 2:7 dosing. A quick-start approach is described where starting with a double dose protects you within two hours.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},401339,1790693631,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":26,"preview_page_count":4},687212989558,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","UK guide to PrEP  \nUK guide to PrEP  \nNovember 2025 13th edition  \nEasier access: anyone who can benefit from PrEP can access it.  \nEvent-based PrEP for all: using either 2:1:1 or 2:7 dosing.  \nQuick-start PrEP: starting with a double dose protects you in two hours.  \n[i-Base.info](i-Base.info)  \nUK guide to PrEP  \nContents  \nChanges to this edition 3  \nGetting PrEP in the UK 3  \nWhat is PrEP: first questions 4  \nPrEP for women 8  \nPrEP for trans and non-binary people 10  \nPrEP and sex work 11  \nBuying PrEP in the UK, including online 11  \nBefore you start PrEP 13  \nCare if you have already started PrEP 14  \nHow to start and stop oral PrEP 15  \nDaily PrEP 16  \nEvent-based PrEP 17  \nEvent-based 2:1:1 dosing: sex once 18  \nEvent-based 2:1:1 dosing: more sex 19  \nEvent-based 2:7 dosing 20  \nOther tips on how to take PrEP 21  \nCredits and further information 24  \nWritten by Dan Clutterbuck, Simon Collins, Sheena McCormack, Achyuta Nori, Will Nutland, Greg Owen, Mags Portman*, Michelle Ross, Sophie Strachan, Martina Toby, Laura Waters, Ashwin Caffery and Aedan Wolton. Cover graphic: [iwantPrEPnow.co.uk](iwantPrEPnow.co.uk).  \n*This guide is dedicated to our inspirational co-author Dr Mags Portman who was a leading advocate for PrEP in the UK. Mags died from  \nmesothelioma in February 2019 aged 44 and we miss her deeply. Thanks to the London Borough of Lambeth.  \nISSN 2398-6409 (i-Base, London, 13th edition, November 2025) .  \n2 November 2025  \nUK guide to PrEP  \nChanges to this edition  \nThis updated guide is based on the 2025 UK PrEP guidelines ([www.bashh.org](www.bashh.org)).  \n• They include that everyone who can benefit from PrEP should now be able to get it free on the NHS.  \n• Start oral PrEP with a double first dose (two pills) . This gives full protection after two hours.  \n• Event-based dosing can also now be used by everyone. This uses either 2:1:1 or 2:7 dosing.  \n• Everyone taking at least four daily doses a week will get good protection.  \n• Both versions of oral PrEP can be used in the same ways (ie TD/FTC and TAF/FTC) .  \n• There is new info on injectable PrEP and doxyPEP.  \nGetting PrEP in the UK  \nPrEP is available free from sexual health clinics.  \nThese sites let you search for a clinic by postcode: [Scotland:](Scotland: www.prep.scot)[ www.prep.scot](Scotland: www.prep.scot)  \n[Wales:](Wales: www.shwales.online/wales-prep-project.html)[ www.shwales.online/wales-prep-project.html](Wales: www.shwales.online/wales-prep-project.html)  \nNorthern [Ireland:](Ireland: www.rainbow-project.org/prep)[ www.rainbow-project.org/prep](Ireland: www.rainbow-project.org/prep)  \n[England:](England: www.nhs.uk/nhs-services/sexual-health)[ www.nhs.uk/nhs-services/sexual-health](England: www.nhs.uk/nhs-services/sexual-health)  \nservices/find-a-sexual-health-clinic/  \nIf a clinic does not want to prescribe you PrEP, please ask them why. They may not know about the new guidelines.  \nNovember 2025 3  \nUK guide to PrEP  \nWhat is PrEP: first questions  \nWhat is PrEP?  \nPrEP stands for Pre-Exposure Prophylaxis.  \nPrEP is taken before sex, so it is pre-exposure. But it also needs to be taken afterwards too. Prophylaxis means to prevent infection.  \nLast year, more than 110,000 people in the UK used oral PrEP.  \nOral PrEP contains two HIV drugs in a single pill. This is usually TD (tenofovir disoproxil) plus FTC. A version using TAF (tenofovir alafenamide) instead of TD is only used if you have kidney or bone issues. Generic TAF/FTC can also be bought cheaply online, see p11 .  \nThere are two injectable versions of PrEP. Cabotegravir (CABLA) is a two-monthly injection for people who can’t take pills. Lenacapavir is a 6-monthly injection that is still in studies.  \nWho can take PrEP?  \n2025 guidelines say that anyone who is HIV negative and who could benefit from PrEP should be able to access it.  \nFor example, if you have used PEP or had a recent STI. Or if you have chemsex or have partners with these risks.  \nYou do not need PrEP if    \n• ","cbCaicMYucEzdq2e","https://ap.wps.com/l/cbCaicMYucEzdq2e","pdf",838107,24,"English","# Changes to this edition\n# Getting PrEP in the UK\n# What is PrEP: first questions\n## Who can take PrEP?\n## How well does PrEP work?\n## PrEP and side effects\n# PrEP and drug resistance","[{\"question\":\"What does PrEP stand for and what is its purpose?\",\"answer\":\"PrEP stands for Pre-Exposure Prophylaxis. It is taken before sex to help prevent HIV infection and it also needs to be taken afterwards too.\"},{\"question\":\"Who can access PrEP in the UK under the 2025 guidelines?\",\"answer\":\"The 2025 guidelines state that anyone who is HIV negative and could benefit from PrEP should be able to access it, including people with recent STI, PEP use, chemsex, or partners with relevant risks.\"},{\"question\":\"How does event-based PrEP dosing work?\",\"answer\":\"Event-based PrEP can use either 2:1:1 or 2:7 dosing. A quick-start approach is described where starting with a double dose protects you within two hours.\"}]","UK guide to PrEP - 13th edition - Updated guidance for November 2025 | PDF",1790519020]