[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331079-105":59,"doc-detail-331079-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ubtd1-is-a-potential-prognostic-biomarker-in-colorectal-cancer-research-study","UBTD1 is a potential prognostic biomarker in colorectal cancer - Research study","","Colorectal cancer (CRC) is a complex malignancy requiring reliable genetic markers for diagnosis and outcome prediction. This study evaluates whether Ubiquitin domain-containing protein 1 (UBTD1) expression relates to clinical and pathological features, using clinical samples and large-scale databases. UBTD1 is upregulated in CRC, linked to advanced T/N/pathological stages and reduced survival. Multivariate Cox regression identifies UBTD1 as an independent unfavorable prognostic marker, with enrichment and immune infiltration analyses suggesting oncogenic activity and associations with macrophages.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ubtd1-is-a-potential-prognostic-biomarker-in-colorectal-cancer-research-study/331079/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ubtd1-is-a-potential-prognostic-biomarker-in-colorectal-cancer-research-study/331079.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main aim of evaluating UBTD1 in colorectal cancer?","Question",{"text":112,"@type":113},"To determine whether UBTD1 expression is associated with clinical/pathological characteristics and whether it has prognostic significance and biological function in CRC.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What relationship was found between UBTD1 expression and patient outcomes?",{"text":117,"@type":113},"UBTD1 expression was upregulated in CRC and linked to decreased survival rates and unfavorable clinical characteristics such as advanced T, N, and pathological stages, with multivariate Cox regression supporting it as an independent prognostic marker.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the study connect UBTD1 to biological mechanisms and the immune microenvironment?",{"text":121,"@type":113},"Functional enrichment and co-expressed gene analysis suggest UBTD1 may act as an oncogene by modulating genes in key tumorigenesis pathways. Immune infiltration analysis indicates UBTD1 levels relate to immune cells, particularly macrophages.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331079,1790070474,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nUBTD1 is a potential prognostic biomarker in colorectal cancer  \nZihan Zhao1,2,5, Changjiang Yang3,5, Xuhua Geng1,2, Congrui Yuan1,2, RuoshenYang4 & Guibin Yang1,2*  \nColorectal cancer (CRC) is a complex malignancy with poorly understood molecular mechanisms, necessitating the identification of genetic markers. Although Ubiquitin domain-containing protein 1 (UBTD1) has received significant attention in the study of human cancers, its specific role in CRC is yet to be fully clarified. This study sought to examine how UBTD1 expression was associated with various clinical and pathological characteristics ofCRC, and to determine its prognostic significance and biological function, utilizing data from clinical samples and large-scale databases. Notably, UBTD1 expression was found to be upregulated in CRC, resulting in decreased survival rates and unfavorable clinical characteristics such as advanced T, N, and pathological stages. The findings ofthe multivariate Cox regression analysis illustrated that UBTD1 expression upregulation is a significant independent marker of unfavorable outcomes inCRC patients. An examination of the functional enrichment of UBTD1 and the genes it co-expresses indicated that it could serve as an oncogene by modulating the expression of genes implicated in crucial tumorigenesis pathways and functions. Additionally, immune cell infiltration analysis suggested a link between UBTD1 levels and various immune cells, particularly macrophages. In conclusion, the use of UBTD1 as a biomarker for both the prognosis and diagnosis of CRC has promising prospects for further investigation and therapeutic approaches.  \nKeywords Ubiquitin domain-containing protein 1, Colorectal cancer, Immune microenvironment, Prognosis  \nColorectal cancer (CRC) is a gastrointestinal tract-associated malignancy that is widely prevalent and has emerged as one of the most frequently occurring tumors on a global scale. An estimated 19.3 million new cases of CRC are diagnosed annually on a global scale, resulting in approximately 10 million deaths1,2. Recent reviews3,4 have pointed out that the CRC incidence rate exhibits regional variations globally, particularly in regions with a low socioeconomic index or undergoing developmental transition, resulting in significant economic and healthcare burdens. Timely detection and treatment of tumors are essential for enhancing CRC outcomes, underscoring the importance of identifying novel biomarkers for early detection and prognosis improvement5–7. Consequently, there is a significant emphasis on conducting additional research to elucidate the pathogenesis and underlying factors contributing to CRC. Ubiquitination is a critical post-translational modification with an essential function in protein degradation and functional regulation. The covalent attachment of ubiquitin to target proteins is critically involved in several cellular processes, such as signal transduction, protein sorting, gene expression, and mitosis8. Ubiquitin domain-containing protein 1 (UBTD1) is a highly conserved ubiquitin-like protein that interacts with specific E2 and E3 enzymes of the ubiquitin–proteasome system (UPS) in both in vitro and in vivo settings9. Research has demonstrated that upregulation of UBTD1 can trigger senescence in human fibroblastsand cancer cells, thereby reducing the oncogenic properties of the cancer cells10. Furthermore, UBTD1 has been shown to enhance the stability of the tumor suppressor p53 protein through the facilitation of Mdm2 protein degradation. The depletion of UBTD1 has been found to significantly influence the mechanical characteristics of epithelial cancer cells by activating RhoA, thereby fostering their aggressive behavior11, 12. Moreover, UBTD1 is mainly implicated in the processes of epidermal growth factor receptor (EGFR) self-phosphorylation and subsequent lysosomal degradation. Depletion of UBTD1 leads","cbCaih5yCoOLN6vs","https://ap.wps.com/l/cbCaih5yCoOLN6vs","pdf",10304318,14,"English","# Introduction\n## Background and rationale\n## UBTD1 in cancer biology\n# Materials and methods\n## Collection and preprocessing of data","[{\"question\":\"What was the main aim of evaluating UBTD1 in colorectal cancer?\",\"answer\":\"To determine whether UBTD1 expression is associated with clinical/pathological characteristics and whether it has prognostic significance and biological function in CRC.\"},{\"question\":\"What relationship was found between UBTD1 expression and patient outcomes?\",\"answer\":\"UBTD1 expression was upregulated in CRC and linked to decreased survival rates and unfavorable clinical characteristics such as advanced T, N, and pathological stages, with multivariate Cox regression supporting it as an independent prognostic marker.\"},{\"question\":\"How does the study connect UBTD1 to biological mechanisms and the immune microenvironment?\",\"answer\":\"Functional enrichment and co-expressed gene analysis suggest UBTD1 may act as an oncogene by modulating genes in key tumorigenesis pathways. Immune infiltration analysis indicates UBTD1 levels relate to immune cells, particularly macrophages.\"}]","UBTD1 is a potential prognostic biomarker in colorectal cancer - Research study | PDF",1789991665,35]