[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331167-105":59,"doc-detail-331167-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ubr5-domains-chance-or-necessity","UBR5 Domains - Chance or Necessity","","Ubiquitinases regulate key physiological processes by catalyzing ubiquitin chain formation on target proteins, including proliferation, autophagy, apoptosis, and cell-cycle progression. As an E3 ligase member of the HECT family, UBR5 (n-recognin 5) is linked to multiple pathophysiological events. This review explains UBR5 structure and function, analyzes its domains individually, and summarizes its roles in immune response, viral infection, DNA damage response, protein quality control, and disease, especially cancers. Detailed domain–substrate mechanisms may support future UBR5-targeted therapeutic strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ubr5-domains-chance-or-necessity/331167/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ubr5-domains-chance-or-necessity/331167.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-09","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is UBR5 and why is it biologically important?","Question",{"text":112,"@type":113},"UBR5 is an E3 ligase component of the HECT family that catalyzes ubiquitination-related regulatory events on target proteins. It is associated with multiple pathophysiological processes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which UBR5 domains does the review focus on?",{"text":117,"@type":113},"The review discusses UBR5 specific domains and explores their biological functions separately.",{"name":119,"@type":110,"acceptedAnswer":120},"How does UBR5 involvement connect to diseases such as cancer?",{"text":121,"@type":113},"The review summarizes UBR5 roles and regulatory mechanisms in cancers and other diseases, including immune response, virus infection, DNA damage response, and protein quality control.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331167,1790280686,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","’Review Article  \nA review: targeting UBR5 domains to mediate emerging roles and mechanisms – chance or necessity?  \nYizhu Wang, MD, Kaiyi Niu, MD, Yanlong Shi, MD, Feilong Zhou, MD, Xinhao Li, MD, Yunxin Li, MD, Tianyi Chen, MD, Yewei Zhang, PhD*  \nAbstract   \nUbiquitinases are known to catalyze ubiquitin chains on target proteins to regulate various physiological functions like cell proliferation, autophagy, apoptosis, and cell cycle progression. As a member of E3 ligase, ubiquitin protein ligase E3 component n-recognin 5 (UBR5) belongs to the HECT E3 ligase and has been reported to be correlated with various pathophysiological processes. In this review, the authors give a comprehensive insight into the structure and function of UBR5 . The authors discuss the specific domains of UBR5 and explore their biological functions separately. Furthermore, the authors describe the involvement of UBR5 in different pathophysiological conditions, including immune response, virus infection, DNA damage response, and protein quality control. Moreover, the authors provide a thorough summary of the important roles and regulatory mechanisms of UBR5 in cancers and other diseases. On the whole, investigating the domains and functions of UBR5, elucidating the underlying mechanisms of UBR5 with various substrates in detail may provide new theoretical basis for the treatment of diseases, including cancers, which could improve future studies to construct novel UBR5-targeted therapy strategies.  \nKeywords: diseases, E3 ligase, pathophysiological function, structure, UBR5  \nIntroduction  \nProteins are the most important performers of vital activities. It was proper protein degradation that is essential to maintain function and homeostasis in organisms[1,2] . The proteasomal and lysosomal pathways are the major protein degradation pathways, which is responsible for cellular processes like cell cycle, signaling, apoptosis, and autophagy[3,4] . Ubiquitin (Ub), a small-molecule protein of 76 amino acid residues, was initially identified as the 26S proteasome trigger for protein degradation in eukaryotic cells, and the ubiquitin proteasome system (UPS) pathway targets the degradation of proteins labeled by Ub selectively[5] . Generally, this process occurs through the sequential action of Ub-activating enzymes (E1), Ub-conjugating enzymes (E2), and Ub ligases (E3).  \nHepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, People ’s Republic of China  \nYizhu Wang, Kaiyi Niu, and Yanlong Shi have contributed equally to this work.  \nSponsorships or competing interests that maybe relevant to content are disclosed atthe end of this article.  \n*Corresponding author. Address: The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province 210003, People’s Republic of China.  \nTel.: +86 138 [138 857 88. E-mail: zhangyewei@njmu.edu.cn](138 857 88. E-mail: zhangyewei@njmu.edu.cn) (Y. Zhang).  \nCopyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms.  \nInternational Journal of Surgery (2024) 110:4947–4964  \nReceived 6 February 2024; Accepted 15 April 2024  \nPublished online 3 May 2024  \n[http://dx.doi.org/10.1097/JS9.0000000000001541](http://dx.doi.org/10.1097/JS9.0000000000001541)  \nHIGHLIGHTS  \n• We give a comprehensive insight into the structure and function of UBR5 .  \n• We discuss the specific domains ofUBR5 and explore their biological functions separately.  \n• We describe the involvement of UBR5 in different pathophysiological conditions, including immune response, virus infection, DNA damage response, and protein quality control.  \n• We provide a thorough summary of the imp","cbCaiakbXmgXb98K","https://ap.wps.com/l/cbCaiakbXmgXb98K","pdf",850024,18,"English","# Abstract\n# Introduction\n# HIGHLIGHTS\n# Ubiquitination mechanisms and E3 ligase classification\n## RING, HECT, and RBR categories","[{\"question\":\"What is UBR5 and why is it biologically important?\",\"answer\":\"UBR5 is an E3 ligase component of the HECT family that catalyzes ubiquitination-related regulatory events on target proteins. It is associated with multiple pathophysiological processes.\"},{\"question\":\"Which UBR5 domains does the review focus on?\",\"answer\":\"The review discusses UBR5 specific domains and explores their biological functions separately.\"},{\"question\":\"How does UBR5 involvement connect to diseases such as cancer?\",\"answer\":\"The review summarizes UBR5 roles and regulatory mechanisms in cancers and other diseases, including immune response, virus infection, DNA damage response, and protein quality control.\"}]","UBR5 Domains - Chance or Necessity | PDF",1789991992,45]