[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-385521-105":59,"doc-detail-385521-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","ubiquitin-specific-peptidases-and-prostate-cancer","Ubiquitin specific peptidases and prostate cancer","","Protein ubiquitination is a key post-translational modification that controls protein stability and activity. Deubiquitinating enzymes (DUBs) reverse ubiquitination by removing ubiquitin(s) from target proteins, with ubiquitin-specific proteases (USPs) forming the largest DUB family. Prostate cancer (PCa) is a leading cause of male cancer death, and PCa development is closely linked to USPs. USP expression in PCa cells modulates downstream signaling, influencing tumor development or suppression. This review summarizes USP roles in PCa development and evaluates their potential as therapeutic targets.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ubiquitin-specific-peptidases-and-prostate-cancer/385521/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ubiquitin-specific-peptidases-and-prostate-cancer/385521.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the role of ubiquitination in cells?","Question",{"text":113,"@type":114},"Ubiquitination is a major post-translational modification that regulates protein function and protein stability, affecting many aspects of cellular physiology.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How do deubiquitinating enzymes (DUBs) influence protein regulation?",{"text":118,"@type":114},"DUBs cleave peptide or isopeptide bonds between ubiquitin molecules or between ubiquitin and modified proteins, reversing ubiquitination and thereby protecting proteins from degradation.",{"name":120,"@type":111,"acceptedAnswer":121},"Why are ubiquitin-specific proteases (USPs) important in prostate cancer?",{"text":122,"@type":114},"USPs are closely correlated with the development and progression of prostate cancer. Their high or low expression in PCa cells regulates downstream signaling pathways, contributing to either development or suppression of the disease.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},385521,1790392600,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":26},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Submitted 17 October 2022  \nAccepted 4 January 2023  \nPublished 16 February 2023  \nCorresponding author  \nDahu Chen, [dahuchen@sdut.edu.cn](dahuchen@sdut.edu.cn), [dahuchen@outlook.com](dahuchen@outlook.com)  \nAcademic editor Sonia Oliveira  \nAdditional Information and Declarations can be found on page 13  \nDOI 10.7717/peerj.14799  \n Copyright 2023 Guo et al.  \nDistributed under  \nCreative Commons CC-BY 4.0  \nOPEN ACCESS  \nUbiquitin specific peptidases and prostate cancer  \nYunfei Guo1 , Shuaishuai Cui1 , Yuanyuan Chen1 , Song Guo1 and Dahu Chen1 Shandong University of Technology, School of Life Sciences and Medicine, Zibo, Shandong, China  \nABSTRACT  \nProtein ubiquitination is an important post-translational modification mechanism, which regulates protein stability and activity. The ubiquitination of proteins can be reversed by deubiquitinating enzymes (DUBs) . Ubiquitin-specific proteases (USPs), the largest DUB subfamily, can regulate cellular functions by removing ubiquitin(s) from the target proteins. Prostate cancer (PCa) is the second leading type of cancer and the most common cause of cancer-related deaths in men worldwide. Numerous studies have demonstrated that the development of PCa is highly correlated with USPs. The expression of USPs is either high or low in PCa cells, thereby regulating the downstream signaling pathways and causing the development or suppression of PCa. This review summarized the functional roles of USPs in the development PCa and explored their potential applications as therapeutic targets for PCa.  \nSubjects Biochemistry, Cell Biology, Molecular Biology  \nKeywords Ubiquitin-specific proteases (USPs), Deubiquitination, Prostate cancer  \nINTRODUCTION  \nRegulation of gene expression is a complex process, involving interactions among DNA, RNA, proteins, and environment. The regulatory process of gene expression occurs at multiple levels to maintain the optimal levels of RNAs and proteins (Tran & Hutvagner, 2013). As an important regulatory mechanism, post-translational modifications (PTMs) are essential for cellular activities. There are several types of PTMs, such as phosphorylation, acetylation, methylation, sumoylation, and ubiquitination; each of them corresponds to one or more specific functions (Millar et al., 2019) .  \nThe ubiquitination of proteins plays a very important role in regulating protein function (Komander & Rape, 2012). It can regulate almost all aspects of cellular physiology (Hu et al., 2021). Ubiquitin, discovered in the 1980s (Cappadocia & Lima, 2018), is an 8.5-kDa small protein, containing 76 amino acids. This protein can be post-translationally attached to the substrate protein, usually at alysine residue (Clague, Heride & Urbé, 2015; Rennie, Chaugule & Walden, 2020). As shown in Fig. 1, ubiquitin can covalently conjugate to the substrate proteins by three different enzymes, including E1, E2, and E3, during ubiquitination (Clague, Heride & Urbé, 2015) . In eukaryotes, the ubiquitin-proteasome system, which is mainly composed of ubiquitin molecules, ubiquitylating enzymes, and 26S proteasomes, is an important pathway for the degradation of damaged or misfolded proteins (Chauhan et al., 2021; Svikle et al., 2022) .  \nHow to cite this article Guo Y, Cui S, Chen Y, Guo S, Chen D. 2023. Ubiquitin specific peptidases and prostate cancer. PeerJ 11:e14799  \n[http://doi.org/10.7717/peerj.14799](http://doi.org/10.7717/peerj.14799)  \nFigure 1 Ubiquitination/deubiquitination modifications and their regulatory role in protein degradation and cellular physiological functions. The process of ubiquitin (ub) binding to substrate proteins in the presence of E1, E2 and E3 . This process is reversible and can remove ubiquitination modifications of substrate proteins in the presence of deubiquitinating enzymes (DUB) . ubiquitination modifications at position K48 are proteins that undergo degradation to protein fragmentation via the 26S proteasome, while ubiquitination modifications at positio","cbCaiaaoWIEkc0s1","https://ap.wps.com/l/cbCaiaaoWIEkc0s1","pdf",3445987,24,"English","# Abstract\n# Introduction","[{\"question\":\"What is the role of ubiquitination in cells?\",\"answer\":\"Ubiquitination is a major post-translational modification that regulates protein function and protein stability, affecting many aspects of cellular physiology.\"},{\"question\":\"How do deubiquitinating enzymes (DUBs) influence protein regulation?\",\"answer\":\"DUBs cleave peptide or isopeptide bonds between ubiquitin molecules or between ubiquitin and modified proteins, reversing ubiquitination and thereby protecting proteins from degradation.\"},{\"question\":\"Why are ubiquitin-specific proteases (USPs) important in prostate cancer?\",\"answer\":\"USPs are closely correlated with the development and progression of prostate cancer. Their high or low expression in PCa cells regulates downstream signaling pathways, contributing to either development or suppression of the disease.\"}]","Ubiquitin specific peptidases and prostate cancer | PDF",1790269775]