[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-376050-105":3,"doc-detail-376050-en":81,"detail-sidebar-cat-0-en-105":98},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","two-simultaneous-primary-cancers-a-case-report","Two Simultaneous Primary Cancers - A Case Report","","When a patient is diagnosed with more than one tumor, these can represent multiple primary neoplasms with distinct histologies and independent origins. The case describes a patient initially diagnosed with undifferentiated pleomorphic sarcoma of the posterior neck, who underwent an extension study before systemic therapy, revealing tumor activity in the left testicle. Radical orchiectomy identified B-cell non-Hodgkin lymphoma. Because metastasis was unlikely, the second lesion required histological confirmation, with staging driven by PET findings.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/two-simultaneous-primary-cancers-a-case-report/376050/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/two-simultaneous-primary-cancers-a-case-report/376050.png","ImageObject",300,407,{"name":42,"@type":43},"Putri","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What does the document describe as “multiple primary tumors” or “synchronous primary cancer”?","Question",{"text":63,"@type":64},"It defines synchronous primary tumors as more than one primary neoplasm occurring in different organs or multiple primary neoplasms of different cell types within the same organ. These neoplasms have different histology and sites of origin and develop independently.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why was histological confirmation considered necessary in this case?",{"text":68,"@type":64},"The document states that, due to the first tumor’s characteristics, it was unlikely to represent metastasis of the known primary cancer. Therefore, the second detected lesion required histological confirmation.",{"name":70,"@type":61,"acceptedAnswer":71},"What diagnoses were ultimately identified for the two simultaneous primary cancers?",{"text":72,"@type":64},"The initial diagnosis was undifferentiated pleomorphic sarcoma (UPS) in the posterior neck region. The extension study led to identification of B-cell non-Hodgkin lymphoma in the left testicle, confirmed after radical orchiectomy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},376050,1790319829,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":86,"language":92,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":93,"faqs":94,"seo_title":95,"seo_description":12,"update_tm":96,"read_time":97},962085571259,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0",7,"Review began 03/19/2025  \nReview ended 04/05/2025  \nPublished 04/10/2025  \n© Copyright 2025  \nGonzalez Aguirre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.81999  \nOpen Access Case Report  \nTwo Simultaneous Primary Cancers: A Case Report  \nCatalina Gonzalez Aguirre 1, Elias Gallardo-Navarro 2, Antonio Castillo Magaña 3  \n1. Oncologic Surgery, Spanish Hospital, Mexico City, MEX 2. General Surgery, Spanish Hospital, Mexico City, MEX 3. Head and Neck Surgery, Spanish Hospital, Mexico City, MEX  \nCorresponding author: Elias Gallardo-Navarro, [gallardo18e@gmail.com](gallardo18e@gmail.com)  \nAbstract  \nWhen a patient is diagnosed with more than one tumor in the same organ or in a different one, there may be multiple primary tumors. We present the case of a patient with an initial diagnosis of undifferentiated pleomorphic sarcoma (UPS) of the posterior region of the neck in whom an extension study was requested after surgery prior to the systemic therapy; tumor activity was identified in the left testicle, and radical orchiectomy was performed with the result of non-Hodgkin lymphoma (NHL) B cells. Multiple primary neoplasms have different histologies and different sites of origin. The interest of the case arises from the clinical presentation in which the patient is being staged due to a previously diagnosed malignant tumor, and a second tumor is detected in the positron emission tomography (PET) scan. Because of the characteristics of the first neoplasm, it is very unlikely that it could correspond to metastasis of the known primary tumor; therefore, it is suspected to be another primary tumor that requires histological confirmation.  \nCategories: General Surgery, Pathology, Oncology  \nKeywords: head and neck neoplasms, multiple primary tumors, primary testicular lymphoma, soft tissue sarcoma, synchronous tumor  \nIntroduction  \nMultiple primary tumors or synchronous primary cancer are defined as the coexistence of more than one primary neoplasm in different organs, or the coexistence of two or more primary neoplasms of different cell types in the same organ, these multiple primary neoplasms have different histology and site of origin and these cancers develop independently of each other, risk factors associated with this condition such as genetic burden such as BRCA mutations, hormonal factors such as hormone therapy, prior exposures to cancer diagnosis and treatment, harmful agents such as alcohol and tobacco, as well as environmental influences such as areas with increased radon exposure and workers exposed to asbestos associated with mesothelioma, viruses such as Epstein-Barr virus and human papillomavirus are related to cancers [1,2] . The two most common definitions currently in use are those provided by the Surveillance Epidemiology and End Results (SEER) project and the International Association of Cancer Registries (IACR) and the International Agency for Research on Cancer (IARC) [2] . The SEER database recommends using a two-month period to distinguish between synchronous and metachronous multiple primaries. Rules according to the IARC suggest the registration of synchronous tumors diagnosed in an interval of less than six months or metachronous if more than six months, if arising in different sites [1-3]. The synchronous primary tumors in our patient include an undifferentiated pleomorphic sarcoma in the posterior region of the left neck and a second primary tumor, diagnosed through an extension study using positron emission tomography (PET), which was compatible with B-cell non-Hodgkin lymphoma (NHL) in the left testicle.  \nSarcoma currently represents approximately 1% of tumors in the adult population. The presentation in the head and neck region is rare, particularly those in the soft tiss","cbCaifp4xMl14pNI","https://ap.wps.com/l/cbCaifp4xMl14pNI","pdf",4020333,"English","# Abstract\n# Introduction\n# Case Context and Definitions\n# Undifferentiated Pleomorphic Sarcoma (UPS)\n# Primary Testicular Lymphoma\n# Therapeutic Strategy Considerations","[{\"question\":\"What does the document describe as “multiple primary tumors” or “synchronous primary cancer”?\",\"answer\":\"It defines synchronous primary tumors as more than one primary neoplasm occurring in different organs or multiple primary neoplasms of different cell types within the same organ. These neoplasms have different histology and sites of origin and develop independently.\"},{\"question\":\"Why was histological confirmation considered necessary in this case?\",\"answer\":\"The document states that, due to the first tumor’s characteristics, it was unlikely to represent metastasis of the known primary cancer. Therefore, the second detected lesion required histological confirmation.\"},{\"question\":\"What diagnoses were ultimately identified for the two simultaneous primary cancers?\",\"answer\":\"The initial diagnosis was undifferentiated pleomorphic sarcoma (UPS) in the posterior neck region. The extension study led to identification of B-cell non-Hodgkin lymphoma in the left testicle, confirmed after radical orchiectomy.\"}]","Two Simultaneous Primary Cancers - A Case Report | PDF",1790217121,18,{"code":4,"msg":82,"data":99},[100,104,108,112,117,122,125,130,135,138,142],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":109,"show_sort_weight":110,"slug":111},"Exam",70,"exam",{"id":113,"doc_module":4,"doc_module_name":25,"category_name":114,"show_sort_weight":115,"slug":116},5,"Comic",60,"comic",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":119,"show_sort_weight":120,"slug":121},6,"Technology",50,"technology",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":123,"slug":124},40,"healthcare",{"id":126,"doc_module":4,"doc_module_name":25,"category_name":127,"show_sort_weight":128,"slug":129},8,"Research & Report",30,"research-report",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":133,"slug":134},9,"Religion & Spirituality",20,"religion-spirituality",{"id":133,"doc_module":4,"doc_module_name":25,"category_name":136,"show_sort_weight":133,"slug":137},"World Cup","world-cup",{"id":139,"doc_module":4,"doc_module_name":25,"category_name":140,"show_sort_weight":139,"slug":141},10,"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":25,"category_name":144,"show_sort_weight":113,"slug":145},19,"General","general"]