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A literature search targeted 2013–2023 publications in Google Scholar and PubMed. Results show improved tumor detection and visualization, more precise targeting with less damage to nearby tissues, and better drug solubility, distribution, absorption, and tumor uptake. Findings support their potential to mitigate chemotherapy challenges and enable innovative diagnostic and therapeutic strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tunable-theranostics-innovative-strategies-in-combating-oral-cancer/329969/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tunable-theranostics-innovative-strategies-in-combating-oral-cancer/329969.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the objective of this study?","Question",{"text":112,"@type":113},"To assess and compare the potential of advanced nano/micro delivery systems as theranostic platforms for oral cancer and evaluate their respective advantages and disadvantages.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which delivery platforms were examined as theranostic systems?",{"text":117,"@type":113},"Quantum dots, carbon nanotubes, magnetic nanoparticles, dendrimers, and microneedles.",{"name":119,"@type":110,"acceptedAnswer":120},"What advantages did the advanced delivery platforms show compared with conventional techniques?",{"text":121,"@type":113},"They improved tumor detection and visualization, enabled more precise targeting with reduced harm to neighboring tissues, and enhanced drug solubility, distribution, absorption, and tumor uptake.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329969,1790803983,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099513958607,"https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399","Submitted 19 July 2023  \nAccepted 6 December 2023 Published 4 January 2024  \nCorresponding author Natheer H. Al-Rawi,  \n[nhabdulla@sharjah.ac.ae](nhabdulla@sharjah.ac.ae)[ ](nhabdulla@sharjah.ac.ae)Academic editor Mohd Adnan  \nAdditional Information and Declarations can be found on page 19  \nDOI 10.7717/peerj.16732  \n Copyright 2024 Uthman et al.  \nDistributed under  \nCreative Commons CC-BY 4.0  \nOPEN ACCESS  \nTunable theranostics: innovative strategies in combating oral cancer  \nAsmaa Uthman1 , Noor AL-Rawi2 , Musab Hamed Saeed3 ,4 , Bassem Eid5 and Natheer H. Al-Rawi6 ,7  \n1 Department of Diagnostic and Surgical Dental Sciences, College of Dentistry, Gulf Medical University, Ajman, United Arab Emirates  \n2 Department of Pharmaceutics and Pharmaceutical Technology, University of Sharjah, Sharjah, United Arab Emirates  \n3 Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates  \n4 Ajman University, Centre of Medical and Bio-allied Health Sciences Research,, Ajman, United Arab Emirates  \n5 Department of Restorative Dental Sciences, College of Dentistry, Gulf Medical University, Ajman, Ajman, United Arab Emirates  \n6 University of Sharjah, Sharjah Institute of Medical Research, Sharjah, United Arab Emirates  \n7 Department of Oral and Craniofacial Health Sciences, College of Dental Medicine, University of Sharjah, Sharjah, United Arab Emirates  \nABSTRACT  \nObjective. This study aims to assess and compare the potential of advanced nano/micro delivery systems, including quantum dots, carbon nanotubes, magnetic nanoparticles, dendrimers, and microneedles, as theranostic platforms for oral cancer. Furthermore, we seek to evaluate their respective advantages and disadvantages over the past decade. Materials and Methods. A comprehensive literature search was performed using Google Scholar and PubMed, with a focus on articles published between 2013 and 2023. Search queries included the specific advanced delivery system as the primary term, followed by oral cancer as the secondary term (e.g., ``quantum dots AND oral cancer,'' etc. ) .  \nResults. The advanced delivery platforms exhibited notable diagnostic and therapeutic advantages when compared to conventional techniques or control groups. These benefits encompassed improved tumor detection and visualization, enhanced precision in targeting tumors with reduced harm to neighboring tissues, and improved drug solubility and distribution, leading to enhanced drug absorption and tumor uptake. Conclusion. The findings suggest that advanced nano/micro delivery platforms hold promise for addressing numerous challenges associated with chemotherapy. By enabling precise targeting of cancerous cells, these platforms have the potential to mitigate adverse effects on surrounding healthy tissues, thus encouraging the development of innovative diagnostic and therapeutic strategies for oral cancer.  \nSubjects Biotechnology, Oncology, Pathology  \nKeywords Theranostics, Quantum dots, Carbon nanotubes, Magnetic nanoparticles, Dendrimers, Microneedles, Oral cancer  \nINTRODUCTION  \nOral cancer is the most common violent cancer that infiltrates local tissue, and can metastasize to other body parts (Ghazawi et al., 2020) . It is a challenging ailment affecting  \nHow to cite this article Uthman A, AL-Rawi N, Saeed MH, Eid B, Al-Rawi NH. 2024. Tunable theranostics: innovative strategies in  \ncombating oral cancer. PeerJ 12:e16732 [http://doi.org/10.7717/peerj.16732](http://doi.org/10.7717/peerj.16732)  \napproximately 600,000 people worldwide annually with a high rate of morbidity and mortality (Ahmadian et al., 2019) . Despite the extensive research on this cancer over the past 20 years, the survival rate has not considerably increased (Chang et al., 2013), which is estimated to be about 50 to 60%, with a wide range recurrence rate of 18􀀕76%(Ahmadian et al., 2019) . The conventional diagnostic approach involving biopsy or histological assessment not only consumes valu","cbCaivpUjyCQVedm","https://ap.wps.com/l/cbCaivpUjyCQVedm","pdf",2476227,26,"English","# Abstract\n# Introduction\n## Background on oral cancer and limitations of current diagnosis and treatment\n## Role of cancer nanotechnology and targeted delivery\n## Promising role of nanomedicine and combinatorial chemotherapy","[{\"question\":\"What was the objective of this study?\",\"answer\":\"To assess and compare the potential of advanced nano/micro delivery systems as theranostic platforms for oral cancer and evaluate their respective advantages and disadvantages.\"},{\"question\":\"Which delivery platforms were examined as theranostic systems?\",\"answer\":\"Quantum dots, carbon nanotubes, magnetic nanoparticles, dendrimers, and microneedles.\"},{\"question\":\"What advantages did the advanced delivery platforms show compared with conventional techniques?\",\"answer\":\"They improved tumor detection and visualization, enabled more precise targeting with reduced harm to neighboring tissues, and enhanced drug solubility, distribution, absorption, and tumor uptake.\"}]","Tunable theranostics: innovative strategies in combating oral cancer | PDF",1789986364,66]