[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-338382-105":59,"doc-detail-338382-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tumour-immunotherapy-and-applications-of-immunological-products-a-review-of-literature-review","Tumour Immunotherapy and Applications of Immunological Products - A Review of Literature - review","","Malignant tumors drive a major global health burden, with millions of deaths reported in 2022 and continued growth in incidence expected by 2050. Tumor immunotherapy is emphasized as a preferred strategy because it can precisely target malignant cells while strengthening immune responses. The review analyzes molecular mechanisms linking tumor cells, the immune system, and the tumor microenvironment, focusing on immune evasion and cancer progression. It critically evaluates cancer vaccines, adoptive T cell therapies, cytokine-based treatments, and emerging combination regimens to improve efficacy and safety while addressing resistance and personalization.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tumour-immunotherapy-and-applications-of-immunological-products-a-review-of-literature-review/338382/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tumour-immunotherapy-and-applications-of-immunological-products-a-review-of-literature-review/338382.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are malignant tumors considered a leading global health challenge?","Question",{"text":112,"@type":113},"Malignant tumors are associated with uncontrolled cellular proliferation and contribute to large numbers of deaths worldwide. The incidence is projected to rise substantially toward 2050.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does tumor immunotherapy differ from traditional cancer therapies?",{"text":117,"@type":113},"Tumor immunotherapy harnesses the body’s immune system to recognize and destroy malignant cells, aiming for more durable responses and fewer side effects. The review also contrasts immunotherapy with issues like toxicity and recurrence in surgery, radiation, and chemotherapy.",{"name":119,"@type":110,"acceptedAnswer":120},"Which immunotherapy approaches are evaluated in the review?",{"text":121,"@type":113},"The review critically evaluates cancer vaccines, adoptive T cell therapies, and cytokine-based treatments. It also discusses recent advances in combination therapies that integrate multiple strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338382,1790742782,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Wiley  \nJournal of Immunology Research Volume 2024, Article ID 8481761, 21 pages [https://doi.org/10.1155/2024/8481761](https://doi.org/10.1155/2024/8481761)  \nReview Article  \nTumour Immunotherapy and Applications of Immunological Products: A Review of Literature  \nAngus Nnamdi Oli , 1 Samson Adedeji Adejumo ,2,3 Adekunle Babajide Rowaiye ,4,5 Joyce Oloaigbe Ogidigo ,4 Jarrad Hampton-Marcell ,2 and Gordon C. Ibeanu 5  \n1Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 420211, Nigeria  \n2Department of Biological Sciences, University of Illinois, Chicago, 845 West Taylor, Chicago 60607, Illinois, USA  \n3Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Federal University Oye Ekiti, Oye, Ekiti State, Nigeria  \n4National Biotechnology Development Agency, Abuja 900211, Nigeria  \n5Department of Pharmaceutical Science, North Carolina Central University, Durham 27707, North Carolina, USA  \nCorrespondence should be addressed to Samson Adedeji Adejumo; [sadeju2@uic.edu](sadeju2@uic.edu)[ ](sadeju2@uic.edu)Received 20 March 2024; Revised 23 September 2024; Accepted 28 September 2024 Academic Editor: Rahul Shivahare  \nCopyright © 2024 Angus Nnamdi Oli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nMalignant tumors, characterized by uncontrolled cell proliferation, are a leading global health challenge, responsible for over 9.7 million deaths in 2022, with new cases expected to rise to 35 million annually by 2050 . Immunotherapy is preferred to other cancer therapies, offering precise targeting of malignant cells while simultaneously strengthening the immune system’s complex responses. Advances in this novel field of science have been closely linked to a deeper knowledge of tumor biology, particularly the intricate interplay between tumor cells, the immune system, and the tumor microenvironment (TME), which are central to cancer progression and immune evasion. This review offers a comprehensive analysis of the molecular mechanisms that govern these interactions, emphasizing their critical role in the development of effective immunotherapeutic products. We critically evaluate the current immunotherapy approaches, including cancer vaccines, adoptive T cell therapies, and cytokine-based treatments, highlighting their efficacy and safety. We also explore the latest advancements in combination therapies, which synergistically integrate multiple immunotherapeutic strategies to overcome resistance and enhance therapeutic outcomes. This review offers key insights into the future of cancer immunotherapy with a focus on advancing more effective and personalized treatment strategies.  \nKeywords: biologics; cancer; immune therapy; immunological products; malignant; tumors  \n1. Introduction  \nA tumor is a mass of tissue caused by the aberrant and excessive proliferation of cells. Compared with the normal surrounding tissue, tumors continue to grow in an uncoordinated manner even after the original trigger is removed [1] . Tumors could either be benign when they do not invade nearby tissue or metastasize throughout the body; premalignant when they have not spread but have the potential to become malignant; or malignant when they are cancerous [2] . Malignant tumors, also referred to as cancers are group  \nof diseases characterized by their unregulated cellular proliferation, their capacity to infiltrate adjacent tissues, and their potential to metastasize to distant regions of the body [3] . These tumors pose a significant health burden globally, being one of the leading causes of death. Cancer is a leading cause of mortality globally, with nearly 20 million new cases and approximately 9.7 million cancer-related deaths reported in 2022 alone. The global burd","cbCaicipUv00tF71","https://ap.wps.com/l/cbCaicipUv00tF71","pdf",1638862,21,"English","# Introduction\n## Tumor immunotherapy and rationale\n## Challenges and scope of the review\n# Immunotherapy approaches\n## Cancer vaccines\n## Adoptive T cell therapies\n## Cytokine-based treatments\n# Combination therapies and future directions\n## Synergistic regimens to overcome resistance\n## Personalized immunotherapeutic development","[{\"question\":\"Why are malignant tumors considered a leading global health challenge?\",\"answer\":\"Malignant tumors are associated with uncontrolled cellular proliferation and contribute to large numbers of deaths worldwide. The incidence is projected to rise substantially toward 2050.\"},{\"question\":\"How does tumor immunotherapy differ from traditional cancer therapies?\",\"answer\":\"Tumor immunotherapy harnesses the body’s immune system to recognize and destroy malignant cells, aiming for more durable responses and fewer side effects. The review also contrasts immunotherapy with issues like toxicity and recurrence in surgery, radiation, and chemotherapy.\"},{\"question\":\"Which immunotherapy approaches are evaluated in the review?\",\"answer\":\"The review critically evaluates cancer vaccines, adoptive T cell therapies, and cytokine-based treatments. It also discusses recent advances in combination therapies that integrate multiple strategies.\"}]","Tumour Immunotherapy and Applications of Immunological Products - A Review of Literature - review | PDF",1790023375,53]