[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330126-105":59,"doc-detail-330126-en":122},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":115,"head_meta":117,"extra_data":119,"updated_unix":121},105,"en","tumorigenic-and-tumoricidal-properties-of-exosomes-in-cancers-a-forward-look","Tumorigenic and tumoricidal properties of exosomes in cancers - a forward look","","Recent decades of emerging evidence highlight the pivotal role of extracellular vesicles, especially exosomes, in the progression and development of multiple cancer types. These nano-sized vesicles are released by diverse cell lineages in the cancer niche and act as paracrine platforms for signaling exchange. Exosomes can convey oncogenic factors, modulate immune-cell activity, reshape the tumor microenvironment, promote tumor expansion, and drive metastasis. Complex cell-to-cell crosstalk mechanisms remain debated, so this review focuses on molecular pathways of oncogenic exosomes and details tumoricidal effects of exosomes from stem-cell sources.",{"@graph":69,"@context":114},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tumorigenic-and-tumoricidal-properties-of-exosomes-in-cancers-a-forward-look/330126/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tumorigenic-and-tumoricidal-properties-of-exosomes-in-cancers-a-forward-look/330126.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108],{"name":109,"@type":110,"acceptedAnswer":111},"How do exosomes contribute to treatment resistance?","Question",{"text":112,"@type":113},"The document links tumor heterogeneity with increased drug resistance and recurrence, and it frames exosome-driven signaling as part of the broader processes that can alter tumor behavior and cellular interactions.","Answer","https://schema.org",{"og:url":83,"og:type":116,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":118,"canonical":83},"index,follow",{"doc_id":120,"site_id":62},330126,1790491262,{"code":4,"msg":5,"data":123},{"doc_id":120,"user_id":124,"nickname":92,"user_avatar":125,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":126,"file_id":127,"file_url":128,"file_type":129,"file_size":130,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":131,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":132,"faqs":133,"seo_title":134,"seo_description":67,"update_tm":135,"read_time":136,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","Abbasi‑Malati et al.  \nCell Communication and Signaling (2024) 22:130 [https://doi.org/10.1](https://doi.org/10.1) 186/s12964‑024‑01510‑3  \nCell Communication and Signaling  \n REVIEW Open Access  \nTumorigenic and tumoricidal properties of exosomes in cancers; a forward look  \nZahra Abbasi‑Malati1, Seyed Ghader Azizi2, Soheil Zamen Milani3, Zeinab Aliyari Serej1, Narges Mardi4, Zahra Amiri5, Zohreh Sanaat6 and Reza Rahbarghazi 1,7*  \nAbstract  \nIn recent decades, emerging data have highlighted the critical role of extracellular vesicles (EVs), especially (exosomes) Exos, in the progression and development of several cancer types. These nano‑sized vesicles are released by differ‑ ent cell lineages within the cancer niche and maintain a suitable platform for the interchange of various signaling molecules in a paracrine manner. Based on several studies, Exos can transfer oncogenic factors to other cells, and alter the activity of immune cells, and tumor microenvironment, leading to the expansion of tumor cells and metastasis to the remote sites. It has been indicated that the cell‑to‑cell crosstalk is so complicated and a wide array of factors are involved in this process. How and by which mechanisms Exos can regulate the behavior of tumor cells and non‑can‑ cer cells is at the center of debate. Here, we scrutinize the molecular mechanisms involved in the oncogenic behavior of Exos released by different cell lineages of tumor parenchyma. Besides, tumoricidal properties of Exos from various stem cell (SC) types are discussed in detail.  \nKeywords Exosomes, Oncogenic properties, Resistance mechanisms, Tumoricidal effects, Stem cells  \nIntroduction  \nCancer diseases have been debilitating conditions inhuman medicine in the last decades with high-rate morbidity and mortality [1]. In clinical settings, surgical approaches, chemotherapy, radiation, and neo-adjuvant  \n*Correspondence: Reza Rahbarghazi  \n[rezarahbardvm@gmail.com](rezarahbardvm@gmail.com); [rahbarghazir@tbzmed.ac.ir](rahbarghazir@tbzmed.ac.ir)  \n1 Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran  \n2 Clinical Immunology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran  \n3 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran  \n4 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran  \n5 Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran  \n6 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran  \n7 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran  \ntherapies are still effective strategies for early cancer treatment [2]. Despite recent advances in cancer theranostics, tumor heterogeneity increases the probability of drug resistance, leading to treatment failure and cancer recurrence [3]. During the last decades, the advent and development of stem cell-related technologies have led to prominent progress in the treatment and alleviation of several pathological conditions [4]. Different stem cell types, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and adult stem cells exhibit differentiation capacity to several lineages, making them as valid cell source for restoration of injured cells [5]. Among different stem cell types, adult mesenchymal stem cells (MSCs) have been extensively applied in various diseases with eminent regenerative outcomes. However, data confirmed that small fractions of transplanted MSCs are alive after direct introduction into the injured sites or a very low cell population can be recruited into the targeted sites after systemic administration [6, 7]. In light of these outcomes, it is believed  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use,","cbCaivsJOvJdn2IV","https://ap.wps.com/l/cbCaivsJOvJdn2IV","pdf",5395123,"English","# Abstract\n# Introduction","[{\"question\":\"How do exosomes contribute to treatment resistance?\",\"answer\":\"The document links tumor heterogeneity with increased drug resistance and recurrence, and it frames exosome-driven signaling as part of the broader processes that can alter tumor behavior and cellular interactions.\"}]","Tumorigenic and tumoricidal properties of exosomes in cancers - a forward look | PDF",1789987321,76]