[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-375808-105":59,"doc-detail-375808-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tumor-organoids-in-cancer-medicine-from-model-systems-to-natural-compound-screening","Tumor organoids in cancer medicine - from model systems to natural compound screening","","Tissue engineering advances have accelerated the development of three-dimensional tumor organoid models. Tumor organoids are self-assembled clusters that reproduce key histopathological, genetic, and phenotypic traits of primary tissues, enabling more faithful in vitro modeling. This review evaluates obstacles in building models that capture tumor heterogeneity and summarizes how organoids support cancer research, with emphasis on natural product screening for antitumor therapies. It also synthesizes literature sources and highlights patient-derived organoid applications.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tumor-organoids-in-cancer-medicine-from-model-systems-to-natural-compound-screening/375808/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tumor-organoids-in-cancer-medicine-from-model-systems-to-natural-compound-screening/375808.png","ImageObject",300,407,{"name":92,"@type":93},"Rhys","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes tumor organoids valuable in cancer research?","Question",{"text":112,"@type":113},"Tumor organoids are 3D, self-assembled models that preserve histological, genetic, and phenotypic characteristics of primary tissues, better reflecting tumor heterogeneity than many traditional models.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What is the main focus of this review?",{"text":117,"@type":113},"The review discusses challenges in creating in vitro models that represent tumor heterogeneity and explains how tumor organoids are used in cancer research, especially for screening natural products for antitumor therapies.",{"name":119,"@type":110,"acceptedAnswer":120},"How were studies selected for the review?",{"text":121,"@type":113},"The review synthesized information from major databases and selected publications without date restrictions, using terms such as organoid and natural product, while excluding work related to agriculture/ecology/synthetic work and non-English publications.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},375808,1790523629,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Pharmaceutical Biology 2025, Vol. 63, No. 1, 89–109  \n[https://doi.org/10.1080/13880209.2025.2458149](https://doi.org/10.1080/13880209.2025.2458149)  \nReview ARticle  \nTumor organoids in cancer medicine: from model systems to natural compound screening  \nRong conga* , can lub*, Xinying lia, Zhijie Xub, Yaqin wangc and Shusen Sund  \naDepartment of general Surgery, Xiangya hospital, central South university, changsha, china; bDepartment of Pathology, National clinical research center for geriatric Disorders, Xiangya hospital, central South university, changsha, china; cclinical research center for reproduction and genetics in hunan Province, reproductive and genetic hospital of citic-Xiangya, changsha, china; dcollege of Pharmacy and health Sciences, Western New england university, Springfield, ma, uSa  \nABSTRACT  \nContext: the advent of tissue engineering and biomedical techniques has significantly advanced the development of three-dimensional (3D) cell culture systems, particularly tumor organoids. these self-assembled 3D cell clusters closely replicate the histopathological, genetic, and phenotypic characteristics of primary tissues, making them invaluable tools in cancer research and drug screening.  \nObjective: this review addresses the challenges in developing in vitro models that accurately reflect tumor heterogeneity and explores the application of tumor organoids in cancer research, with a specific focus on the screening of natural products for antitumor therapies.  \nMethods: this review synthesizes information from major databases, including chemical Abstracts, Medicinal and Aromatic Plants Abstracts, ScienceDirect, Google Scholar, Scopus, PubMed and Springer link. Publications were selected without date restrictions, using terms such as ‘organoid’, ‘natural product’,‘pharmacological’, ‘extract’, ‘nanomaterial’ and ‘traditional uses’. Articles related to agriculture, ecology, synthetic work or published in languages other than english were excluded.  \nResults and conclusions: the review identifies key challenges related to the efficiency and variability of organoid generation and discusses ongoing efforts to enhance their predictive capabilities in drug screening and personalized medicine. Recent studies utilizing patient-derived organoid models for natural compound screening are highlighted, demonstrating the potential of these models in developing new classes of anticancer agents. the integration of natural products with patient-derived organoid models presents a promising approach for discovering novel anticancer compounds and elucidating their mechanisms of action.  \nARTICLE HISTORY  \nreceived 26 august 2024 revised 4 December 2024 accepted 17 January 2025  \nKEYWORDS  \ncancer; organoids; natural products; nanomaterial  \nIntroduction  \nDuring the past few decades, scientists worldwide have intensified their efforts in cancer research, leading to significant progress in diagnosis and treatment. Despite these advances, cancer remains the second leading cause of death globally, accounting for nearly 10 million deaths annually. This high mortality rate is primarily due to inefficient early-stage diagnostic methods and the lack of drugs targeting personalized biomarkers (Contessi Negrini et al. 2023; Zhou, Huang, et al. 2023) . Tumor modeling has become a crucial component of cancer research, aiming to elucidate morphogenetic developmental processes to advance biomedical research and pave the way for precision medicine. Traditional in vivo animal models, two-dimensional (2D) cultured cell lines, and patient-derived tumor xenografts (PDTXs) are commonly used in contemporary cancer research (Fan et al. 2019; Mazzocchi et al. 2019; Yang et al. 2023) . However, these models often fail to accurately replicate the  \nstructural, biochemical, and biophysical complexities, as well asthe heterogeneity, of native tumors, thereby limiting their potential for clinical translation. The characteristics of different tumor models are det","cbCaitod6UlA42iM","https://ap.wps.com/l/cbCaitod6UlA42iM","pdf",5214419,21,"English","# Abstract\n# Introduction\n# Tumor organoids as model systems\n# Methods and literature sources\n# Results and conclusions","[{\"question\":\"What makes tumor organoids valuable in cancer research?\",\"answer\":\"Tumor organoids are 3D, self-assembled models that preserve histological, genetic, and phenotypic characteristics of primary tissues, better reflecting tumor heterogeneity than many traditional models.\"},{\"question\":\"What is the main focus of this review?\",\"answer\":\"The review discusses challenges in creating in vitro models that represent tumor heterogeneity and explains how tumor organoids are used in cancer research, especially for screening natural products for antitumor therapies.\"},{\"question\":\"How were studies selected for the review?\",\"answer\":\"The review synthesized information from major databases and selected publications without date restrictions, using terms such as organoid and natural product, while excluding work related to agriculture/ecology/synthetic work and non-English publications.\"}]","Tumor organoids in cancer medicine - from model systems to natural compound screening | PDF",1790216217,53]