[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332566-105":3,"doc-detail-332566-en":81,"detail-sidebar-cat-0-en-105":99},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","tumor-microenvironment-characteristics-association-with-clinical-outcome-in-patients-with-resected-intestinal-type-gastric-cancer","Tumor microenvironment characteristics association with clinical outcome in patients with resected intestinal-type gastric cancer","","Background: Tumor microenvironment (TME) characteristics including tumor stroma ratio (TSR), tumor budding (TB), and tumor-infiltrating lymphocytes (TILs) were examined in resected gastric cancer. Background rationale links these TME features to metastatic potential seen in colon cancer, with intestinal-type gastric cancer sharing pathological similarities. Methods: TSR, TB, and TILs were quantified from 493 patients (2010–2016) undergoing radical resection at two university hospitals in China, and TME variables were related to TTR and CSS using univariate and multivariate analyses, including relative contribution via Cox regression.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/tumor-microenvironment-characteristics-association-with-clinical-outcome-in-patients-with-resected-intestinal-type-gastric-cancer/332566/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/tumor-microenvironment-characteristics-association-with-clinical-outcome-in-patients-with-resected-intestinal-type-gastric-cancer/332566.png","ImageObject",300,407,{"name":42,"@type":43},"Riley","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Which tumor microenvironment features were evaluated and in what cancer type?","Question",{"text":63,"@type":64},"The study evaluated tumor stroma ratio (TSR), tumor budding (TB), and tumor-infiltrating lymphocytes (TILs) in patients with resected intestinal-type gastric cancer.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the association between TME features and clinical outcomes analyzed?",{"text":68,"@type":64},"TME variables were quantified from routine histological sections and related to time-to-recurrence (TTR) and cancer-specific survival (CSS) using univariate and multivariate analysis, with relative contribution assessed via Cox regression.",{"name":70,"@type":61,"acceptedAnswer":71},"Which feature showed the strongest independent prognostic association?",{"text":72,"@type":64},"TSR was independently associated with both TTR and CSS after adjustment, whereas PLR showed an independent association with TTR only.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332566,1790154687,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":85,"doc_module":4,"category_id":86,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":87,"file_id":88,"file_url":89,"file_type":90,"file_size":91,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":92,"language":93,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":94,"faqs":95,"seo_title":96,"seo_description":12,"update_tm":97,"read_time":98,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051",8,"Tumor microenvironment characteristics association with clinical outcome in patients with resected intestinal-type gastric cancer  \nChun-Fang Tian1,‡,, Hai-Yan Jing2,‡,‖, Frank A. Sinicrope3, Jin-Shen Wang4, Bin-Bin Gao1, Xiao-Gang Sun1, Zhi-Gang Yao2,, Le-Ping Li4, Bahar Saberzadeh-Ardestani5, Wei Song1,*, Dan Sha1,*,  \n1Department of Minimally Invasive Treatment of Cancer, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People’s Republic of China,  \n2Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People’s Republic of China,  \n3Department of Oncology, Mayo Clinic, Rochester, 55905, United States,  \n4Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, People’s Republic of China, and  \n5Gastrointestinal Research Unit, Mayo Clinic, Rochester, 55905, United States  \n* Corresponding author: Dan Sha, MD, Department of Minimally Invasive Treatment of Cancer, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jingwuweiqi Road 324, Jinan,Shandong Province, 250021, People’s Republic of China ([shadan@sdfmu.edu.cn](shadan@sdfmu.edu.cn)); or, Wei Song, MD, Department of Minimally Invasive Treatment of Cancer, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jingwuweiqi Road 324, Jinan, Shandong Province, 250021, People’s Republic of China ([sdslyysw@163.com](sdslyysw@163.com)) .  \n‡Chun-Fang Tian and Hai-Yan Jing contributed equally.  \n‖Hai-Yan Jing is the co-first author of this paper.  \nAbstract  \nBackground: Tumor microenvironment (TME) characteristics including tumor stroma ratio (TSR), tumor budding (TB), and tumor-infiltrating lymphocytes (TILs) were examined in resected gastric cancer. These TME features have been shown to indicate metastatic potential in colon cancer, and intestinal-type gastric cancer (IGC) has pathological similarities with that malignancy.  \nMethods: TSR, TB, and TILs were quantified in routine histological sections from 493 patients with IGC who underwent radical resection at 2 university hospitals in China from 2010 to 2016. TME variables were dichotomized as follows: TSR (50%), TILs (median), TB per international guidelines (4 buds/0 .785mm2), and platelet-lymphocyte ratio (PLR) per survival ROC. Association ofTME features with patient clinicopathological characteristics, time-to-recurrence (TTR), and cancer-specific-survival (CSS) were examined using univariate and multivariate analysis, including a relative contribution analysis by Cox regression.  \nResults: Patients whose tumors showed highTSR or highTB or low TILs were each significantly associated with increased T and N stage, higher histological grade, and poorer TTR and CSS at 5 years. Only TSR and N stage were independently associated with TTR and CSS after adjustment for covariates. PLR was only independently associated with TTR after adjustment for covariates. Among the variables examined, only TSR was significantly associated with both TTR (HR 1.72, 95% CI, 1.14-2.60, P = .01) and CSS (HR 1.62, 95% CI, 1.05-2. 51, P = .03) multivariately. Relative contribution toTTR revealed that the top 3 contributors were N stage (45 . 1%), TSR (22 . 5%), and PLR (12 .9%), while the top 3 contributors to CSS were N stage (59 .9%), TSR (14 .7%), and PLR (10 .9%) .  \nConclusions: Among the examined TME features, TSR was the most robust for prognostication and was significantly associated with both TTRand CSS. Furthermore, the relative contribution ofTSR to patient TTR and CSS was second only to nodal status.  \nKey words: intestinal-type gastric cancer; tumor stroma ratio; tumor infiltrating lymphocytes; tumor budding; prognosis.  \nReceived: 22 January 2024; Accepted: 4 May 2024.  \n© The Author(s) 2024. Published by Oxford University Press.  \nThis is an Open Access article distributed u","cbCaioDyUV4sxAIq","https://ap.wps.com/l/cbCaioDyUV4sxAIq","pdf",11641855,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Key words","[{\"question\":\"Which tumor microenvironment features were evaluated and in what cancer type?\",\"answer\":\"The study evaluated tumor stroma ratio (TSR), tumor budding (TB), and tumor-infiltrating lymphocytes (TILs) in patients with resected intestinal-type gastric cancer.\"},{\"question\":\"How was the association between TME features and clinical outcomes analyzed?\",\"answer\":\"TME variables were quantified from routine histological sections and related to time-to-recurrence (TTR) and cancer-specific survival (CSS) using univariate and multivariate analysis, with relative contribution assessed via Cox regression.\"},{\"question\":\"Which feature showed the strongest independent prognostic association?\",\"answer\":\"TSR was independently associated with both TTR and CSS after adjustment, whereas PLR showed an independent association with TTR only.\"}]","Tumor microenvironment characteristics association with clinical outcome in patients with resected intestinal-type gastric cancer | PDF",1789998741,28,{"code":4,"msg":82,"data":100},[101,105,109,113,117,122,127,130,135,138,142],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":106,"show_sort_weight":107,"slug":108},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":110,"show_sort_weight":111,"slug":112},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":114,"show_sort_weight":115,"slug":116},"Comic",60,"comic",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":119,"show_sort_weight":120,"slug":121},6,"Technology",50,"technology",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":125,"slug":126},7,"Healthcare",40,"healthcare",{"id":86,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":128,"slug":129},30,"research-report",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":133,"slug":134},9,"Religion & Spirituality",20,"religion-spirituality",{"id":133,"doc_module":4,"doc_module_name":25,"category_name":136,"show_sort_weight":133,"slug":137},"World Cup","world-cup",{"id":139,"doc_module":4,"doc_module_name":25,"category_name":140,"show_sort_weight":139,"slug":141},10,"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":25,"category_name":144,"show_sort_weight":55,"slug":145},19,"General","general"]