[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-373511-105":59,"doc-detail-373511-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tumor-derived-exosomes-and-their-application-in-cancer-treatment","Tumor-derived exosomes and their application in cancer treatment","","Tumor-derived exosomes (TDEs) are nanoscale vesicles secreted by cancer cells that strengthen intercellular communication within the tumor microenvironment. Packed with bioactive proteins, lipids, RNA, and DNA, TDEs can drive angiogenesis, immune evasion, and metastasis, accelerating tumor progression. Their distinct molecular profiles motivate interest in TDEs as biomarkers and as novel delivery vehicles for therapeutics and immune-modulating agents. 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They carry bioactive molecules that can promote angiogenesis, immune evasion, and metastasis, enhancing tumor progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can TDEs be used in cancer diagnostics and treatment?",{"text":117,"@type":113},"TDEs may serve as noninvasive biomarkers and support targeted early detection. They also have potential as vehicles for delivering anti-cancer drugs and immune-modulating compounds.",{"name":119,"@type":110,"acceptedAnswer":120},"What challenges must be addressed before TDEs reach clinical use?",{"text":121,"@type":113},"Standardization, reproducibility, and immune interaction challenges need to be resolved. Continued interdisciplinary research is required to fully realize clinical potential.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},373511,1790240288,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Javdani‑Mallak et al.  \nJournal of Translational Medicine (2025) 23:751 [https://doi.org/10.1](https://doi.org/10.1) 186/s12967‑025‑06814‑7  \nJournal of Translational Medicine  \n REVIEW Open Access  \nTumor‑derived exosomes and their application in cancer treatment  \nAfsaneh Javdani-Mallak1, Seyed Javad Mowla 1 and Mona Alibolandi2,3*  \nAbstract  \nBackground Tumor-derived exosomes (TDEs) are vesicles characterized by their nanoscale size, secreted  \nthrough cancer cells to boost the intercellular communications of the tumor microenvironment. TDEs enclose a cocktail of bioactive molecules, such as proteins, lipids, RNA, and DNA, which can encourage angiogenesis, immune evasion, and metastasis to enhance tumor progression. Researchers are now interested in tumor-derived exosomesas markers and potential novel vehicles for the delivery of therapeutics in cancer treatment since they exhibit different molecular profiles and biological functions.  \nMethods PubMed, Scopus, and Google Scholar were methodically explored for articles estimating the dual functions of TDEs and their potential applications as new therapeutic targets and drug delivery vehicles for the transportation of anti-cancer drugs and immune-modulating compounds.  \nResult TDEs represent great promise in advancing cancer diagnostics and therapy through their portrayal in cell communication, tumor regulation, and immune modulation. They offer potential for noninvasive, targeted treatment and early detection. However, standardization, reproducibility, and immune interaction challenges must be addressed. Continued interdisciplinary research is essential to realize their clinical potential fully.  \nConclusion Advancements in exosome engineering denote auspicious alternatives to conventional cancer therapies, with benefits like reduced toxicity and enhanced targeting. Understanding the biology ofTDEs implements the development of novel treatments and improves diagnostics, prognostics, and monitoring of cancer progression. Integrating TDE-based tools with personalized medicine credits the potential to transform cancer care by providing more effective and individualized therapies.  \nKeyword Tumor cell-derived exosomes, Engineering exosomes, Cancer, Tumor microenvironment  \n*Correspondence:  \nMona Alibolandi  \n[alibolandim@mums.ac.ir](alibolandim@mums.ac.ir)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/.)[.](http://creativecommons.org/licenses/by-nc-nd/4.0/.)  \nJavdani‑Mallak etal. Journal of Translational Medicine (2025) 23:751 Page 2 of 44  \nGraphical Abstract  \nBackground  \nThe main feature of the exosomes is that they are small extracellular vesicles (30–150 NM in diameter) occupied by membranes. Their formation and secretion are usually from all kinds of cells, and exosomes are released into different body fluids, including blood, urine, and saliva. Besides that, these e","cbCaiam4e7bejqKS","https://ap.wps.com/l/cbCaiam4e7bejqKS","pdf",2371246,44,"English","# Abstract\n## Background\n## Methods\n## Result\n## Conclusion\n# Graphical Abstract\n## Background","[{\"question\":\"What are tumor-derived exosomes (TDEs) and what roles do they play in cancer?\",\"answer\":\"TDEs are nanoscale vesicles secreted by cancer cells. They carry bioactive molecules that can promote angiogenesis, immune evasion, and metastasis, enhancing tumor progression.\"},{\"question\":\"How can TDEs be used in cancer diagnostics and treatment?\",\"answer\":\"TDEs may serve as noninvasive biomarkers and support targeted early detection. They also have potential as vehicles for delivering anti-cancer drugs and immune-modulating compounds.\"},{\"question\":\"What challenges must be addressed before TDEs reach clinical use?\",\"answer\":\"Standardization, reproducibility, and immune interaction challenges need to be resolved. Continued interdisciplinary research is required to fully realize clinical potential.\"}]","Tumor-derived exosomes and their application in cancer treatment | PDF",1790199765,111]