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Post-treatment tumoral calcification is uncommon in HCC and is rarely reported after drug-eluting beads TACE (DEB-TACE). CASE SUMMARY: Two patients with large solitary HCCs (>5 cm) received DEB-TACE and achieved complete radiological response after two sessions; after about 1 year peripheral tumoral calcification progressed, and both maintained remission over 6 years with preserved liver function. CONCLUSION: Peripheral calcification may indicate late effective tumor necrosis and durable treatment response, warranting prospective prognostic studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tumor-calcification-and-sustained-complete-response-after-chemoembolization-in-hepatocellular-carcinoma-two-case-reports-and-review-of-literature/406503/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tumor-calcification-and-sustained-complete-response-after-chemoembolization-in-hepatocellular-carcinoma-two-case-reports-and-review-of-literature/406503.png","ImageObject",300,407,{"name":92,"@type":93},"Stanford","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What clinical setting does the article address for hepatocellular carcinoma?","Question",{"text":112,"@type":113},"It focuses on unresectable hepatocellular carcinoma treated with transarterial chemoembolization, specifically drug-eluting beads TACE (DEB-TACE). The report highlights complete radiological response and subsequent post-treatment tumoral calcification.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the two cases treated and what imaging outcome was observed?",{"text":117,"@type":113},"Two patients with large solitary HCCs (>5 cm) were treated with DEB-TACE, achieving complete radiological response after two treatment sessions. About one year later, progressive peripheral tumoral calcification appeared on imaging.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the proposed significance of peripheral tumoral calcification after DEB-TACE?",{"text":121,"@type":113},"The article suggests peripheral calcification may serve as a late imaging marker of effective tumor necrosis and durable treatment response. It also notes that prospective studies are needed to clarify prognostic value.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},406503,1790767384,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},2336477552062,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2025 December 15; 17(12): 113341  \nDOI: 10.4251/wjgo.v17.i12.113341 ISSN 1948-5204 (online)  \nCASE REPORT  \nTumor calcification and sustained complete response after chemoembolization in hepatocellular carcinoma: Two case reports and review of literature  \nSultan R Alharbi  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade C, Grade C  \nNovelty: Grade B, Grade B, Grade B  \nCreativity or Innovation: Grade B, Grade B, Grade B  \nScientific Significance: Grade A, Grade B, Grade C  \nP-Reviewer: Cui P, PhD, Senior Scientist, China; Jia KF, PhD, China; Li DH, MD, Chief Physician, Professor, China  \nReceived: August 22, 2025  \nRevised: September 22, 2025  \nAccepted: October 13, 2025  \nPublished online: December 15, 2025  \nProcessing time: 111 Days and 9.8 Hours  \nSultan R Alharbi, Interventional Radiology Unit/Department of Radiology and Medical Imaging, College of Medicine, King Saud University, Riyadh 11362, Saudi Arabia  \nCorresponding author: Sultan R Alharbi, MD, Associate Professor, Interventional Radiology Unit/Department of Radiology and Medical Imaging, College of Medicine, King Saud University, PO Box 7805, King Abdullah Street, Riyadh 11362, Saudi Arabia.  \n[drsultan000@gmail.com](drsultan000@gmail.com)  \nAbstract  \nBACKGROUND  \nTransarterial chemoembolization (TACE) is a widely accepted palliative therapy modality for unresectable hepatocellular carcinoma (HCC) . Although it is rarely curative, complete radiological response can be achieved in selected patients, leading to prolonged survival. Post-treatment tumoral calcification is an uncom-mon imaging finding in HCC and is rarely reported after drug-eluting beads TACE (DEB-TACE) .  \nCASE SUMMARY  \nTwo patients with large, solitary HCCs (> 5 cm) were treated with DEB-TACE, and both achieved complete radiological response after two treatment sessions. Approximately 1 year after DEB-TACE, imaging demonstrated progressive peripheral tumoral calcification. Over 6 years of follow-up, both patients remained inremission with preserved liver function.  \nCONCLUSION  \nThese two cases highlight the potential for complete remission and long-term survival in selected patients with large HCC following DEB-TACE. The appearance of peripheral calcification may represent a late imaging marker of effective tumor necrosis and durable treatment response although prospective studies are warranted to clarify its prognostic value.  \nKey Words: Hepatocellular carcinoma; Transarterial chemoembolization; Drug-eluting beads chemoembolization; Complete response; Remission; Tumoral calcification; Case report  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 15, 2025  Volume 17  Issue 12   \nAlharbi SR. Complete remission and calcification of HCC  \nCore Tip: Tumoral calcification following transarterial chemoembolization (TACE) for hepatocellular carcinoma is a rare imaging finding, and its clinical significance remains unclear. This case report describes 2 patients with large hepatocellular carcinoma who developed complete radiological response after drug-eluting beads TACE, followed by progressive peripheral calcification and sustained disease-free survival for 6 years. The notable association between post-TACE calcification and long-term remission raises the possibility that calcification may serve as a late imaging biomarker of effective tumor necrosis and durable treatment response.  \nCitation: Alharbi SR. Tumor calcification and sustained complete response after chemoembolization in hepatocellular carcinoma: Two case reports and ","cbCaip4GkTVacLiO","https://ap.wps.com/l/cbCaip4GkTVacLiO","pdf",11906137,12,"English","# Abstract\n## Background\n## Case summary\n## Conclusion\n# Introduction","[{\"question\":\"What clinical setting does the article address for hepatocellular carcinoma?\",\"answer\":\"It focuses on unresectable hepatocellular carcinoma treated with transarterial chemoembolization, specifically drug-eluting beads TACE (DEB-TACE). The report highlights complete radiological response and subsequent post-treatment tumoral calcification.\"},{\"question\":\"How were the two cases treated and what imaging outcome was observed?\",\"answer\":\"Two patients with large solitary HCCs (\\u003e5 cm) were treated with DEB-TACE, achieving complete radiological response after two treatment sessions. About one year later, progressive peripheral tumoral calcification appeared on imaging.\"},{\"question\":\"What is the proposed significance of peripheral tumoral calcification after DEB-TACE?\",\"answer\":\"The article suggests peripheral calcification may serve as a late imaging marker of effective tumor necrosis and durable treatment response. It also notes that prospective studies are needed to clarify prognostic value.\"}]","Tumor calcification and sustained complete response after chemoembolization in hepatocellular carcinoma - Two case reports and review of literature | PDF",1790566128]