[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379001-105":59,"doc-detail-379001-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tumor-biology-and-immune-infiltration-define-primary-liver-cancer-subsets-linked-to-overall-survival-after-immunotherapy","Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy","","Budhu et al. define molecular indicators of immunotherapy response in primary liver cancer by integrating transcriptome and genome analyses of archived FFPE specimens from the NCI-CLARITY retrospective cohort. Across 86 hepatocellular carcinoma and cholangiocarcinoma patients, baseline tumors form stable gene clusters and transcriptomic subtypes associated with overall survival and treatment response. Immune infiltration and microenvironmental features differ between subtypes, while few transcriptome alterations occur after immunotherapy. Stratification by molecular status may help identify patients most likely to benefit from immune checkpoint inhibitors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tumor-biology-and-immune-infiltration-define-primary-liver-cancer-subsets-linked-to-overall-survival-after-immunotherapy/379001/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tumor-biology-and-immune-infiltration-define-primary-liver-cancer-subsets-linked-to-overall-survival-after-immunotherapy/379001.png","ImageObject",300,407,{"name":92,"@type":93},"\tJames","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What data sources and sample type were used to assess immunotherapy response?","Question",{"text":112,"@type":113},"The study used archived formalin-fixed, paraffin-embedded (FFPE) specimens and performed integrated transcriptome and genome assessment before and after immune checkpoint inhibitor treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What did the researchers find about molecular subtypes and survival?",{"text":117,"@type":113},"Baseline tumors formed stable molecular gene clusters and transcriptomic subtypes that were linked to overall survival and treatment response.",{"name":119,"@type":110,"acceptedAnswer":120},"How did tumor molecular profiles change after immunotherapy?",{"text":121,"@type":113},"Few transcriptome changes occurred in tumors after immunotherapy, suggesting that baseline molecular states were more informative for response than post-treatment transcriptomic shifts.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379001,1790305086,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Article  \nTumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy  \nAuthors  \nAnuradha Budhu, Erica C. Pehrsson, Aiwu He, ..., Marshonna Forgues, Tim F. Greten, Xin Wei Wang  \nCorrespondence  \n[tim.greten@nih.gov](tim.greten@nih.gov) (T.F.G.),  \n[xw3u@nih.gov](xw3u@nih.gov) (X.W.W.)  \nIn brief  \nBudhu et al. identify molecular indicators of the immunotherapy response of liver cancer patients, paramount for improved clinical management. Integrated transcriptome and genome assessment of FFPE specimens prior to and following immunotherapy among the NCI-CLARITY retrospective cohort shows stable molecular subtypes linked to survival, immune alterations, and treatment response.  \nd Molecular assessment of immune treatment response is feasible with FFPE specimens  \nd Baseline tumors form stable gene clusters linked to survival and treatment response  \nd Baseline clusters exhibit transcriptomic, mutational, and immune response differences  \nd Few transcriptome changes occur in tumors after immunotherapy  \nBudhu et al., 2023, Cell Reports Medicine 4, 101052 June 20, 2023  \n[https://doi.org/10.1016/j.xcrm.2023.101052](https://doi.org/10.1016/j.xcrm.2023.101052)  \nll  \nll  \nOPEN ACCESS  \nArticle  \nTumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy  \nAnuradha Budhu,1,2,15 Erica C. Pehrsson,1,3,4,15 Aiwu He,5 Lipika Goyal,6 Robin Kate Kelley,7 Hien Dang,8,9 Changqing Xie,10 Cecilia Monge,10 Mayank Tandon,3,4 Lichun Ma,2 Mahler Revsine,2 Laura Kuhlman,5 Karen Zhang,7 Islam Baiev,6 Ryan Lamm,8,9 Keyur Patel,8,9 David E. Kleiner,11 Stephen M. Hewitt,11 Bao Tran,12 Jyoti Shetty,12 Xiaolin Wu,13 Yongmei Zhao,4 Tsai-Wei Shen,4 Sulbha Choudhari,4 Yuliya Kriga,4 Kris Ylaya,11 Andrew C. Warner,14 Elijah F. Edmondson,14 Marshonna Forgues,2 Tim F. Greten,1,10,* and Xin Wei Wang1,2,16,*  \n1Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  \n2Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  \n3CCR Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  \n4Advanced Biomedical Computational Science, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA  \n5Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA  \n6Department of Medical Oncology, Mass General Cancer Center, Harvard Medical School, Boston, MA 02114, USA  \n7Department of Medicine (Hematology/Oncology), UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94143, USA  \n8Department of Surgery, Thomas Jefferson University, Philadelphia, PA, USA  \n9Sidney Kimmel Cancer Center, Philadelphia, PA 19107, USA  \n10Gastrointestinal Malignancies Section, Thoracic and GI Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA  \n11Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 21701, USA  \n12Sequencing Facility, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA  \n13Genomics Technology Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA  \n14Molecular Histopathology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701, USA  \n15These authors contributed equally  \n16Lead contact  \n*Correspondence: [tim.greten@nih.gov](tim.greten@nih.gov) (T.F.G.), [xw3u@nih.gov](xw3u@nih.gov) (X.W.W.) [https://doi.org/10.1016/j.xcrm.2023.101052](https://doi.org/10.1016/j.xcrm.2023.101052)  \nSUMMARY  \nPrimary liver cancer is a ri","cbCaibnGd1xVHlpE","https://ap.wps.com/l/cbCaibnGd1xVHlpE","pdf",4182843,23,"English","# Summary\n# Introduction\n# Article details","[{\"question\":\"What data sources and sample type were used to assess immunotherapy response?\",\"answer\":\"The study used archived formalin-fixed, paraffin-embedded (FFPE) specimens and performed integrated transcriptome and genome assessment before and after immune checkpoint inhibitor treatment.\"},{\"question\":\"What did the researchers find about molecular subtypes and survival?\",\"answer\":\"Baseline tumors formed stable molecular gene clusters and transcriptomic subtypes that were linked to overall survival and treatment response.\"},{\"question\":\"How did tumor molecular profiles change after immunotherapy?\",\"answer\":\"Few transcriptome changes occurred in tumors after immunotherapy, suggesting that baseline molecular states were more informative for response than post-treatment transcriptomic shifts.\"}]","Tumor biology and immune infiltration define primary liver cancer subsets linked to overall survival after immunotherapy | PDF",1790233594,58]