[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378521-105":59,"doc-detail-378521-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tumor-angiogenesis-in-gastric-cancer-original-paper","Tumor angiogenesis in gastric cancer - Original paper","","Gastric cancer remains a major cause of cancer-related death worldwide. Angiogenesis—the formation of new blood vessels—supports tumor progression by enabling oxygen, nutrients, and growth factors to reach cancer cells. The study reports high vascularity in gastric neoplasms with anarchic, uneven distribution in the tumor stroma, including congested vessels and microhemorrhages. Vessels show immature structure with hyperpermeability and low pericyte numbers, reflecting young, functionally immature tumor vessels.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tumor-angiogenesis-in-gastric-cancer-original-paper/378521/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tumor-angiogenesis-in-gastric-cancer-original-paper/378521.png","ImageObject",300,407,{"name":92,"@type":93},"Guten tag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is angiogenesis important in gastric cancer progression?","Question",{"text":112,"@type":113},"Angiogenesis supplies oxygen, nutrients, and growth factors to tumor cells and supports dissemination to distant organs.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What vascular features were observed in gastric neoplasms?",{"text":117,"@type":113},"Gastric tumors showed high vascularity with anarchic, uneven distribution in the stroma, including congested vessels and microhemorrhages, with many vessels as capillaries.",{"name":119,"@type":110,"acceptedAnswer":120},"How do tumor vessels reflect maturation status in this study?",{"text":121,"@type":113},"Tumor angiogenesis vessels had a low number of pericytes, indicating young vessels that are morphologically and functionally immature.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378521,1790378134,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","Rom J Morphol Embryol 2023, 64(3):311–318 ISSN (print) 1220–0522, ISSN (online) 2066–8279 doi: 10.47162/RJME.64.3.03  \nORIGINAL PAPER  \nR J M E  \nRomanian Journal of Morphology & Embryology  \n[http://www.rjme.ro/](http://www.rjme.ro/)  \nTumor angiogenesis in gastric cancer  \nALEXANDRU GIUBELAN1), MARIUS IONUŢ STANCU2), SORINA OCTAVIA HONŢARU3), GHEORGHE DAN MĂLĂESCU4), OANA BADEA-VOICULESCU5), CAMELIA FIROIU6), STELIAN ŞTEFĂNIŢĂ MOGOANTĂ7,8)  \n1) PhD Student, Doctoral School, Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania  \n2) PhD Student, Department of Histology, University of Medicine and Pharmacy of Craiova, Romania  \n3) Department of Health Care and Physiotherapy, Faculty of Sciences, Physical Education and Informatics, University of Piteşti, Romania  \n4) Department of Anatomy, Faculty of Nursing, Târgu Jiu Subsidiary, Titu Maiorescu University, Bucharest, Romania  \n5) Department of Modern Languages, University of Medicine and Pharmacy of Craiova, Romania  \n6) Department of Pathology, Emergency County Hospital, Târgu Jiu, Romania  \n7) Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania  \n8)3rd General Surgery Clinic, Emergency County Hospital, Craiova, Romania  \nAbstract  \nGastric cancer (GC) is still a major health problem, being one of the leading causes of cancer-related death in the world. Although the overall incidence of GC is decreasing in the United States and Western Europe, it is still high in many countries from Asia, South America, and Eastern Europe. The process of angiogenesis or the formation of new blood vessels plays an important role in cancer progression, as it allows oxygen supply, nutrients, and factors to grow tumor cells. In our study, we found that gastric neoplasms have high vascularity, with anarchic distribution, uneven in tumor stroma, sometimes with congestion vessels and microhemorrhages. Most vessels were capillaries, with a discontinuous endothelium, poorly structured basement membrane, without junctions between endothelial cells, hyperpermeable, creating the possibility of local edema in the tumor microenvironment (TME), and also extravasation of the plasma, leukocytes and even red blood cells. Angiogenesis vessels showed a low number of pericytes, which shows that they are young vessels, both morphologically and functionally immature. Tumor cells can synthesize biochemical factors [vascular endothelial growth factor-A (VEGF-A)] that stimulate the formation of new vessels (angiogenesis) to ensure their growth and metastasis. Some connective cells (tumor-associated mast cells, tumor-associated fibroblasts) are also involved in the angiogenesis process, which stimulate the progression of tumor cells and remodel the TME.  \nKeywords: gastric cancer, angiogenesis, endothelial cells, vascular endothelial growth factor, mast cells, blood vessels.  \n􀀕 Introduction  \nAngiogenesis is a complex process that plays important roles in the growth and development of the human and animal body, in the regeneration of tissues and organs, as well as in numerous pathological conditions.  \nThe angiogenesis process or the formation of new blood vessels, is a distinctive sign of repair, expansion, and remodeling of tissues during physiological processes (such as the development of the embryo, ovulation, and healing of wounds) and in various pathological processes (chronic inflammation, atherosclerosis, and cancer) [1–4] . In embryogenesis, the process of blood vessel formation is highly accelerated, resulting in the formation and development of the cardiovascular system. Embryonic blood vessels are initially formed by vasculogenesis, a process involving the aggregation of endothelial precursor cells (angioblasts) from the embryonic mesenchyme and the formation of simple endothelial tubes [5–7] . In later stages, vascular development occurs through angiogenesis (the formation of new blood vessels from pre-existing ones)  \n[8], resulting in a massive network of arteries","cbCaioWzV3sgZa1H","https://ap.wps.com/l/cbCaioWzV3sgZa1H","pdf",2822226,"English","# Abstract\n# Introduction\n## Angiogenesis in physiology and pathology\n## Endothelial cell roles in angiogenesis\n## Angiogenesis in cancer progression","[{\"question\":\"Why is angiogenesis important in gastric cancer progression?\",\"answer\":\"Angiogenesis supplies oxygen, nutrients, and growth factors to tumor cells and supports dissemination to distant organs.\"},{\"question\":\"What vascular features were observed in gastric neoplasms?\",\"answer\":\"Gastric tumors showed high vascularity with anarchic, uneven distribution in the stroma, including congested vessels and microhemorrhages, with many vessels as capillaries.\"},{\"question\":\"How do tumor vessels reflect maturation status in this study?\",\"answer\":\"Tumor angiogenesis vessels had a low number of pericytes, indicating young vessels that are morphologically and functionally immature.\"}]","Tumor angiogenesis in gastric cancer - Original paper | PDF",1790230431]