[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333273-105":59,"doc-detail-333273-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tsrna-a-promising-biomarker-in-breast-cancer","tsRNA: A Promising Biomarker in Breast Cancer","","tRNA-derived small RNAs (tsRNAs) are non-coding small RNAs generated from specific cleavage sites of tRNA or pre-tRNA. tsRNAs directly participate in RNA silencing, transcription, translation, and related cellular processes. Their dysregulation is strongly linked to cancer occurrence and progression. Breast cancer is common and continues to grow rapidly as a malignant disease. tsRNAs have been reported as dysregulated in breast cancer, suggesting new directions for understanding pathogenesis and serving as tumor biomarkers to support diagnosis and treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tsrna-a-promising-biomarker-in-breast-cancer/333273/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tsrna-a-promising-biomarker-in-breast-cancer/333273.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are tsRNAs and how are they generated?","Question",{"text":112,"@type":113},"tsRNAs are tRNA-derived small non-coding RNAs produced by cleavage at specific sites of tRNA or pre-tRNA. They can be formed from distinct processing events that yield different tsRNA types.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are tsRNAs classified?",{"text":117,"@type":113},"tsRNAs include tRFs (tRNA-derived fragments) and tiRNAs (tRNA-derived stress-induced RNAs). They can be further divided based on the cleavage sites and sequence features.",{"name":119,"@type":110,"acceptedAnswer":120},"Why are tsRNAs considered promising biomarkers for breast cancer?",{"text":121,"@type":113},"tsRNAs are dysregulated in breast cancer and are linked to biological processes involved in cancer development. They are also discussed as potential tumor markers that may support diagnosis and treatment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333273,1790192572,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Review  \nIvyspring  \nInternational Publisher  \nJournal of Cancer  \n2024; 15(9): 2613-2626. doi: 10.7150/jca.93531  \ntsRNA: A Promising Biomarker in Breast Cancer  \nTing Huang1, Yuexin Zhao2, Guoqin Jiang1, Zhixue Yang1􀀍  \n1. Department of Thyroid and Breast Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.  \n2. Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.  \n􀀍 Corresponding author: Zhixue Yang, E-mail address: [yzx0495@suda.edu.cn](yzx0495@suda.edu.cn).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2023.12.23; Accepted: 2024.02.29; Published: 2024.03.11  \nAbstract  \ntRNA-derived small RNAs (tsRNAs) are a novel class of non-coding small RNAs, generated from specific cleavage sites of tRNA or pre-tRNA. tsRNAs can directly participate in RNA silencing, transcription, translation, and other processes. Their dysregulation is closely related to the occurrence and development of various cancers. Breast cancer is one of the most common and fastest-growing malignant tumors in humans. tsRNAs have been found to be dysregulated in breast cancer, serving as a new target for exploring the pathogenesis of breast cancer. They are also considered new tumor markers, providing a basis for diagnosis and treatment. This article reviews the generation, classification, mechanism of action, function of tsRNAs, and their biological effects and related mechanisms in breast cancer, in the hope of providing a new direction for the diagnosis and treatment of breast cancer.  \nKeywords: Breast Cancer; tRF; tiRNA; tsRNA; Biomarker; Liquid Biopsy  \nIntroduction  \ntRNA derived small RNAs (tsRNAs) are a class of non-coding small RNAs, including tRFs (tRNA derived fragments) and tiRNAs (tRNA-derived stress-induced RNA)[1] . With the development of research technology, it has been discovered to be not random products of tRNA degradation but small RNAs that are cleaved according to specific sequencesand are associated with various diseases[2-4] . Depending on the different cleavage sites of tRNAs, tRFs can be divided into tRF-1, tRF-2, tRF-3, tRF-5 and i-tRF, and tiRNA can be classified into 5'-tiRNA and 3'-tiRNA [2, 5] . Extensive research has confirmed that tsRNA can act as functional molecules, thereby affecting the progression of diseases[6-9] .  \nBreast cancer (BC) is a major threaten to women’s health and one of the most prevalent malignant tumors worldwide[10-12] . The International Agency for Research on Cancer (IARC) released the GLOBOCAN 2020 data from 185 countries, which reported 2.26 million incident cases of breast cancer (11.7%), surpassing lung cancer as the most common cancer for the first time, and 680,000 mortality cases (6.9%)[13] . Therefore, investigating the pathogenesis of breast cancer and identifying potential biomarkers  \nfor its diagnosis and treatment are of great value and meaning.  \nThis article reviews the recent advances in the biogenesis, classification, modification and biological functions of tsRNAs. Specifically, we focus on the effects and underlying mechanisms of tsRNAs on breast cancer cell proliferation, metastasis, apoptosis and other biological processes, aiming to explore their potential role in molecular diagnosis and targeted therapy for breast cancer.  \nBiogenesis, classification, and detection methods of tsRNA  \nPre-tRNAs are transcribed by RNA polymerase III, with a leader sequence and a tail sequence at their 5’ and 3’ ends. The leader sequence is subsequently removed by the endonuclease RNase P, which is konwn as a ribonucleoprotein, while the tail sequence is removed by RNase Z, through endo-nucleolytic cleavage exactly at the first unpaired ","cbCaiv6sjY2Eh8Jx","https://ap.wps.com/l/cbCaiv6sjY2Eh8Jx","pdf",2307027,14,"English","# Abstract\n# Introduction\n# Biogenesis, classification, and detection methods of tsRNA\n## tRFs\n## tiRNAs\n# Mechanisms and biological functions of tsRNAs in breast cancer\n## Cell proliferation\n## Metastasis\n## Apoptosis\n## Other biological processes\n# tsRNAs as diagnostic and therapeutic targets\n# Conclusion","[{\"question\":\"What are tsRNAs and how are they generated?\",\"answer\":\"tsRNAs are tRNA-derived small non-coding RNAs produced by cleavage at specific sites of tRNA or pre-tRNA. They can be formed from distinct processing events that yield different tsRNA types.\"},{\"question\":\"How are tsRNAs classified?\",\"answer\":\"tsRNAs include tRFs (tRNA-derived fragments) and tiRNAs (tRNA-derived stress-induced RNAs). They can be further divided based on the cleavage sites and sequence features.\"},{\"question\":\"Why are tsRNAs considered promising biomarkers for breast cancer?\",\"answer\":\"tsRNAs are dysregulated in breast cancer and are linked to biological processes involved in cancer development. They are also discussed as potential tumor markers that may support diagnosis and treatment.\"}]","tsRNA: A Promising Biomarker in Breast Cancer | PDF",1790001759,35]