[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-452732-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-452732-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","trps1plag1-fusion-in-a-primary-cutaneous-myoepithelial-carcinoma-a-case-report-and-literature-review","TRPS1::PLAG1 Fusion in a Primary Cutaneous Myoepithelial Carcinoma - A Case Report and Literature Review","","Myoepithelial carcinomas are rare skin tumors with poor outcomes, characterized by frequent local recurrence and metastasis. Fewer than 30 primary cutaneous cases are described, prompting a literature review that identified 26 reported patients. A new case is presented: an occipital primary cutaneous myoepithelial carcinoma in a 56-year-old individual. RNA sequencing of the tumor revealed a TRPS1::PLAG1 fusion event, reported as the first such fusion associated with primary cutaneous myoepithelial carcinoma.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/trps1plag1-fusion-in-a-primary-cutaneous-myoepithelial-carcinoma-a-case-report-and-literature-review/452732/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/trps1plag1-fusion-in-a-primary-cutaneous-myoepithelial-carcinoma-a-case-report-and-literature-review/452732.png","ImageObject",300,407,{"name":42,"@type":43},"CatatanPagi","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How common are primary cutaneous myoepithelial carcinomas in the literature, and what did the authors do to address this?","Question",{"text":63,"@type":64},"Fewer than 30 cases are reported. The authors performed a literature review and identified 26 known cases of primary cutaneous myoepithelial carcinoma.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What clinical features were reported in the presented case?",{"text":68,"@type":64},"A 56-year-old man had a slowly enlarging, asymptomatic occipital cutaneous mass, with exam revealing a firm 15 cm tumor at the occipital area.",{"name":70,"@type":61,"acceptedAnswer":71},"What molecular finding supported the diagnosis in this case?",{"text":72,"@type":64},"RNA sequencing identified a TRPS1::PLAG1 fusion event in the tumor tissue, described as previously associated with other adnexal and uterine tumors but reported here in primary cutaneous myoepithelial carcinoma for the first time.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},452732,1791304062,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":102,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Journal of Cutaneous Pathology  \nCASE STUDY  OPEN ACCESS   \nTRPS1::PLAG1 Fusion in a Primary Cutaneous Myoepithelial Carcinoma: A Case Report and Literature Review  \nTimber Gillis  | Jenika Howell | Fatemeh Jafarian  \nUniversity of Calgary, Calgary, Canada  \nCorrespondence: Jenika Howell ([jenika.howell@albertaprecisionlabs.ca](jenika.howell@albertaprecisionlabs.ca))  \nReceived: 10 June 2025 | Revised: 28 August 2025 | Accepted: 15 October 2025  \nKeywords: myoepithelial carcinoma | PLAG1 | RNA | sequence analysis | skin neoplasms | TRPS1  \nABSTRACT  \nMyoepithelial neoplasms are rare tumors that are found in the salivary glands, the breast, soft tissue, and skin. Myoepithelial carcinomas typically have a poor prognosis with a high rate of local recurrence and metastasis in the cutaneous setting. There are fewer than 30 described cases of primary cutaneous myoepithelial carcinoma in the literature. We performed a literature review and identified 26 known cases of primary cutaneous myoepithelial carcinoma. Here, we describe a case of occipital primary cutaneous myoepithelial carcinoma occurring in a 56-year-old patient. RNA sequencing was performed on the tumor which identified a TRPS1::PLAG1 fusion event which is to our knowledge, the first time this has been reported in the literature for a primary cutaneous myoepithelial carcinoma.  \n1 | Introduction  \nMyoepithelial neoplasms arise in salivary glands, the breast, soft tissue, and skin. Among these sites, primary cutaneous myoepithelial neoplasms are rare. The tumor exists on a spectrum from benign myoepithelioma, to myoepithelial carcinoma [1] . The histopathology of myoepithelial neoplasms is broad, ranging from an epithelioid to spindled morphology, with reticular to trabecular growth patterns. Some tumors demonstrate a minor ductal component that closely resembles their salivary gland mixed tumor counterparts. By immunohistochemistry, the majority of the tumors are positive for broad-spectrum keratins, S100 protein and calponin [2] . The only reliable features that distinguish a benign myoepithelioma from a myoepithelial carcinoma include moderate to severe nuclear pleomorphism and a high mitotic rate.  \nTo-date there are fewer than 30 primary cutaneous myoepithelial carcinomas reported in the literature [3] . These tumors occur equally in men and women and typically present in the  \n5th to the 6th decade of life. In the soft tissue setting, they are commonly associated with oncogenic EWSR1 RNA fusion events, followed by FUS fusions [4] . While mixed tumors and benign myoepitheliomas in the soft tissue have a relatively indolent course, myoepithelial carcinomas are associated with recurrence and metastases in upwards of 40%–50% of cases [5] . Unfortunately, this is closely mirrored in the cutaneous setting, and patients may present with metastases and regional lymph node involvement at the time of diagnosis [3] .  \n2 | Case Report  \nA 56-year-old man was referred to our clinic with a 6-year history of a slowly enlarging asymptomatic occipital, cutaneous mass. Physical exam revealed a 15 cm firm tumor on the occipital area (Figure 1). There was no regional lymphadenopathy on physical exam, and he did not have any constitutional symptoms concerning for metastases. An initial biopsy revealed a dermalbased myoepithelial neoplasm, composed of spindled and focally  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \n© 2025 The Author(s). Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.  \nJournal of Cutaneous Pathology, 2026; 53:169–174 169  \n[https://doi.org/10.1111/cup.70010](https://doi.org/10.1111/cup.70010)  \nFIGURE 1 | Clinical photograph of the occipital, ulcerated mass measuring 15 cm in maximum dimension.  \nplasmacytoid cell","cbCaif23It0S2vWN","https://ap.wps.com/l/cbCaif23It0S2vWN","pdf",516217,"English","# Introduction\n# Case Report","[{\"question\":\"How common are primary cutaneous myoepithelial carcinomas in the literature, and what did the authors do to address this?\",\"answer\":\"Fewer than 30 cases are reported. The authors performed a literature review and identified 26 known cases of primary cutaneous myoepithelial carcinoma.\"},{\"question\":\"What clinical features were reported in the presented case?\",\"answer\":\"A 56-year-old man had a slowly enlarging, asymptomatic occipital cutaneous mass, with exam revealing a firm 15 cm tumor at the occipital area.\"},{\"question\":\"What molecular finding supported the diagnosis in this case?\",\"answer\":\"RNA sequencing identified a TRPS1::PLAG1 fusion event in the tumor tissue, described as previously associated with other adnexal and uterine tumors but reported here in primary cutaneous myoepithelial carcinoma for the first time.\"}]","TRPS1::PLAG1 Fusion in a Primary Cutaneous Myoepithelial Carcinoma - A Case Report and Literature Review | PDF",1790737634,15]