[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-457299-105":3,"detail-sidebar-cat-0-en-105":85,"doc-detail-457299-en":134},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":78,"head_meta":80,"extra_data":82,"updated_unix":84},105,"en","trimester-specific-reference-values-of-ultrasound-derived-fat-fraction-and-automated-point-shear-wave-elastography-for-liver-assessment-in-healthy-singleton-pregnancies","Trimester-specific reference values of ultrasound-derived fat fraction and automated point shear-wave elastography for liver assessment in healthy singleton pregnancies","","Quantitative ultrasound biomarkers were evaluated to characterize how hepatic fat and stiffness change across pregnancy. Thirty normotensive women with singleton pregnancies underwent liver ultrasonography and biochemical testing in the first, second, and third trimesters. Study outcomes included ultrasound-derived fat fraction (UDFF), liver stiffness parameters (elasticity and shear-wave velocity) and correlations with maternal anthropometrics and serum biomarkers such as ALT, total bile acids, and albumin. UDFF and stiffness increased significantly with gestational age, with strong positive associations among UDFF, shear-wave velocity, BMI, and ALT, supporting trimester-specific reference ranges for noninvasive prenatal liver assessment.",{"@graph":14,"@context":77},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/trimester-specific-reference-values-of-ultrasound-derived-fat-fraction-and-automated-point-shear-wave-elastography-for-liver-assessment-in-healthy-singleton-pregnancies/457299/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/trimester-specific-reference-values-of-ultrasound-derived-fat-fraction-and-automated-point-shear-wave-elastography-for-liver-assessment-in-healthy-singleton-pregnancies/457299.png","ImageObject",300,407,{"name":42,"@type":43},"Đào","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69,73],{"name":60,"@type":61,"acceptedAnswer":62},"What was the purpose of this study?","Question",{"text":63,"@type":64},"To establish trimester-specific reference values for ultrasound-derived fat fraction (UDFF) and automated point shear-wave elastography (Auto-pSWE) in healthy singleton pregnancies and to assess correlations with clinical and biochemical parameters.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were liver measurements obtained across pregnancy trimesters?",{"text":68,"@type":64},"Thirty normotensive women underwent liver ultrasonography and biochemical evaluations during the first (11–13 6/7 weeks), second (20–24 weeks), and third (32–36 weeks) trimesters, including UDFF and liver stiffness measurements (elasticity and shear-wave velocity).",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about UDFF and liver stiffness over time?",{"text":72,"@type":64},"UDFF and liver stiffness parameters increased significantly across trimesters. UDFF rose from the first to the third trimester, and elasticity and shear-wave velocity also increased with gestational age.",{"name":74,"@type":61,"acceptedAnswer":75},"Which variables were most strongly correlated with UDFF and stiffness?",{"text":76,"@type":64},"Strong positive correlations were observed between UDFF and shear-wave velocity, BMI, and ALT, while elasticity showed a significant association with total bile acids. No significant correlations were found with albumin, total bilirubin, or coagulation indices.","https://schema.org",{"og:url":32,"og:type":79,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":81,"canonical":32},"index,follow",{"doc_id":83,"site_id":7},457299,1790794092,{"code":4,"msg":86,"data":87},"success",[88,92,96,100,105,110,114,119,124,127,130],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Exam",70,"exam",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},5,"Comic",60,"comic",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},6,"Technology",50,"technology",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},7,40,"healthcare",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},8,"Research & Report",30,"research-report",{"id":120,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":122,"slug":123},9,"Religion & Spirituality",20,"religion-spirituality",{"id":122,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":122,"slug":126},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},"Lifestyle","lifestyle",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":101,"slug":133},19,"General","general",{"code":4,"msg":86,"data":135},{"doc_id":83,"user_id":136,"nickname":42,"user_avatar":137,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":143,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":12,"update_tm":147,"read_time":148,"preview_page_count":4},1374402968488,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Original Article  \nTrimester-specific reference values of ultrasound-derived fat fraction and automated point shear-wave elastography for liver assessment in healthy singleton pregnancies  \nKe-Xiong Niu1, Jing-Jing Ye2, Xiao-Qiang Liu1, Tian-Gang Li1, Bin Ma1, Qing-Qing Yang1  \n1Department of Ultrasound Diagnosis, Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China; 2Department of Ultrasound Diagnosis, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China  \nContributions: (I) Conception and design: KX Niu, JJ Ye, TG Li; (II) Administrative support: TG Li, B Ma; (III) Provision of study materials or patients: XQ Liu, QQ Yang; (IV) Collection and assembly of data: KX Niu, JJ Ye; (V) Data analysis and interpretation: KX Niu, JJ Ye; (VI)  \nManuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \nCorrespondence to: Dr. Jing-Jing Ye, degree. Department of Ultrasound Diagnosis, Gansu Provincial Hospital of Traditional Chinese Medicine, No.  \n418 Guazhou Road, Qilihe District, Lanzhou 730050, China. Email: [1034289591@qq.com](1034289591@qq.com); Dr. Tian-Gang Li, degree. Department of Ultrasound Diagnosis, Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), No. 143 Qilihe North Street, Qilihe District, Lanzhou 730050, China. Email: [litiangang1981@126.com](litiangang1981@126.com).  \nBackground: Liver health is critical in pregnancy due to this organ adapting to meet gestational metabolic demands. Although overall function typically remains normal, hormonal and metabolic shifts can alter hepatic structure and complicate assessment. Conventional liver tests and imaging (e.g., ultrasonography and biochemical markers) have limited ability to distinguish physiological changes from pathologies such as intrahepatic cholestasis of pregnancy, steatosis, or fibrosis. Ultrasound-derived fat fraction (UDFF) and automated point shear-wave elastography (Auto-pSWE) provide noninvasive, quantitative measures of hepatic fat and stiffness. These techniques are well established in nonpregnant populations, but their applicability for pregnancy-related liver changes remains underexplored. This descriptive pilot study aimed to establish trimester-specific reference values for UDFF and Auto-pSWE in healthy singleton pregnancies and to determine their correlations with clinical and biochemical parameters, thereby providing novel  \nquantitative benchmarks for hepatic assessment during gestation.  \nMethods: Thirty normotensive women with singleton pregnancies underwent liver ultrasonography and biochemical evaluations during the first (11–13⁶⁄₇ weeks), second (20–24 weeks), and third (32–36 weeks) trimesters. Measurements included UDFF, liver stiffness (Young modulus in kilopascals) and shearwave velocity (SWV; in meters per second), maternal anthropometric and serum biomarkers [alanine aminotransferase (ALT), total bile acids, and albumin] . Statistical analyses comprised Kruskal-Wallis tests for  \ncomparing trimesters and Spearman correlation coefficients for assessing associations between variables.  \nResults: Maternal body mass index (BMI) increased significantly across trimesters, from 20.68±1.79 to  \n23.77±1.82 kg/m2 (P\u003C0 . 001) . UDFF values rose markedly, from 1. 92%±0 . 30% in the first trimester to  \n4.58%±1.48% in the third trimester (P\u003C0.001), corresponding to an approximate 139% increase. Liver stiffness parameters also increased significantly with gestational age: elasticity rose from 4.33±0.19 kPa to 5.80±1.43 kPa, while SWV increased from 1.26±0.03 to 1.45±0.05 m/s (both P values \u003C0.001) . Strong positive correlations were observed between UDFF and SWV (r=0.81), BMI (r=0.78), and ALT (r=0.77) (all P values \u003C0.01), indicating an association between hepatic fat accumulation, tissue stiffness, and maternal metabolic status. Elasticity showed a significant association with total bile acids (P\u003C0.05), indicating a pote","cbCaivA6tCX3Rgts","https://ap.wps.com/l/cbCaivA6tCX3Rgts","pdf",417298,"English","# Introduction\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"What was the purpose of this study?\",\"answer\":\"To establish trimester-specific reference values for ultrasound-derived fat fraction (UDFF) and automated point shear-wave elastography (Auto-pSWE) in healthy singleton pregnancies and to assess correlations with clinical and biochemical parameters.\"},{\"question\":\"How were liver measurements obtained across pregnancy trimesters?\",\"answer\":\"Thirty normotensive women underwent liver ultrasonography and biochemical evaluations during the first (11–13 6/7 weeks), second (20–24 weeks), and third (32–36 weeks) trimesters, including UDFF and liver stiffness measurements (elasticity and shear-wave velocity).\"},{\"question\":\"What did the study find about UDFF and liver stiffness over time?\",\"answer\":\"UDFF and liver stiffness parameters increased significantly across trimesters. UDFF rose from the first to the third trimester, and elasticity and shear-wave velocity also increased with gestational age.\"},{\"question\":\"Which variables were most strongly correlated with UDFF and stiffness?\",\"answer\":\"Strong positive correlations were observed between UDFF and shear-wave velocity, BMI, and ALT, while elasticity showed a significant association with total bile acids. No significant correlations were found with albumin, total bilirubin, or coagulation indices.\"}]","Trimester-specific reference values of ultrasound-derived fat fraction and automated point shear-wave elastography for liver assessment in healthy singleton pregnancies | PDF",1790748813,25]