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Comparative data between one-anastomosis gastric bypass (OAGB) and Roux-en-Y gastric bypass (RYGB) are limited. This study compared time-dependent copper trends and deficiency prevalence after OAGB versus RYGB and evaluated associated patient and procedure factors. A single-center retrospective cohort assessed copper before surgery and at 6 and 12 months and used multivariable modeling and ROC analysis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/trends-of-copper-deficiency-following-one-anastomosis-gastric-bypass-and-roux-en-y-gastric-bypass/457700/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/trends-of-copper-deficiency-following-one-anastomosis-gastric-bypass-and-roux-en-y-gastric-bypass/457700.png","ImageObject",300,407,{"name":92,"@type":93},"A glass of water","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-05","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study designed to compare regarding copper deficiency?","Question",{"text":112,"@type":113},"The study compared time-dependent copper trends and the prevalence of copper deficiency after one-anastomosis gastric bypass (OAGB) versus Roux-en-Y gastric bypass (RYGB).","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was copper deficiency defined and when was serum copper measured?",{"text":117,"@type":113},"Serum copper was measured preoperatively and at 6 months and 12 months. Copper deficiency was defined as serum copper \u003C 75 µg/dL.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors were independently associated with copper deficiency at 6 months?",{"text":121,"@type":113},"In adjusted analyses, female sex and greater 6-month percent total weight loss (%TWL) were independently associated with copper deficiency at 6 months; age and procedure type were not.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},457700,1790942190,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962090760832,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Moradi et al. BMC Surgery (2026) 26:20 [https://doi.org/10.1186/s12893-025-03364-z](https://doi.org/10.1186/s12893-025-03364-z)  \nBMC Surgery  \nRESEARCH Open Access  \nTrends of copper deficiency following one anastomosis gastric bypass and Roux-en-Y gastric bypass  \nMohammad Moradi 1, Shahab Shahabi Shahmiri2,3, Masoumeh Shahsavan 1, Mohammad Javad Farzadmanesh 1*, Elyas Mostafapour 1, Faridadin Ebrahimi Meimand 1, Abdol reza Pazouki2,3 and Mohammad Kermansaravi2,3*  \nAbstract  \nBackground Copper deficiency is an under-recognized complication after metabolic and bariatric surgery (MBS) with hematologic and neurologic sequelae. Comparative evidence between one-anastomosis gastric bypass (OAGB) and Roux-en-Y gastric bypass (RYGB) is limited. We compared time-dependent copper trends and deficiency prevalence after OAGB versus RYGB and identified associated factors.  \nMethods We conducted a single-center retrospective cohort study of consecutive adults undergoing primary OAGB or RYGB (January 2020–December 2022) . Serum copper was measured preoperatively and at 6 months and 12 months. Copper deficiency was defined as serum copper \u003C 75 µg/dL. Multivariable logistic regression assessed associations of age, sex, procedure type, and 6-month percent total weight loss (%TWL) with deficiency; receiver operating characteristic (ROC) analysis explored a 6-month %TWL threshold.  \nResults Among 294 patients (OAGB n = 107; RYGB n = 187; mean age 38.8± 9.9 years; 83% women), deficiency prevalence across 6, and 12 months did not differ between procedures. Mean serum copper declined from baseline to 6 months in both groups and remained below baseline at 12 months. In adjusted analyses, female sex and greater 6-month %TWL were independently associated with copper deficiency at 6 months; age and procedure type were not. ROC analysis suggested an exploratory 6-month %TWL threshold of ~ 29% for identifying higher-risk patients (AUC 0 . 64) . No consistent between-group differences were observed in hematologic or iron indices by copper status. Conclusion Copper deficiency rates through 12 months were comparable after OAGB and RYGB; however, mean serum copper declined after both procedures. Greater early weight loss was associated with deficiency, supporting targeted biochemical surveillance—particularly within the first postoperative year—and reinforcement of supplementation adherence.  \nKeywords Bariatric surgery, Copper deficiency, Roux-en-Y gastric bypass, One-anastomosis gastric bypass, Micronutrients  \n*Correspondence:  \nMohammad Javad Farzadmanesh [mj.farzadmanesh@gmail.com](mj.farzadmanesh@gmail.com)[ ](mj.farzadmanesh@gmail.com)Mohammad Kermansaravi  \n[mkermansaravi@yahoo.com](mkermansaravi@yahoo.com); [Kermansaravi.m@iums.ac.ir](Kermansaravi.m@iums.ac.ir)  \n1Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran  \n2Department of Surgery, Minimally Invasive Surgery Research Center, Division of Minimally Invasive and Bariatric Surgery, Hazrat-E Fatemeh Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran  \n3Center of Excellence of European Branch of International Federation for Surgery of Obesity, Hazrat-e Rasool Hospital, Tehran, Iran  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in th","cbCaipxxdjixglCS","https://ap.wps.com/l/cbCaipxxdjixglCS","pdf",1292211,"English","# Introduction\n# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Keywords","[{\"question\":\"What was the study designed to compare regarding copper deficiency?\",\"answer\":\"The study compared time-dependent copper trends and the prevalence of copper deficiency after one-anastomosis gastric bypass (OAGB) versus Roux-en-Y gastric bypass (RYGB).\"},{\"question\":\"How was copper deficiency defined and when was serum copper measured?\",\"answer\":\"Serum copper was measured preoperatively and at 6 months and 12 months. Copper deficiency was defined as serum copper \\u003c 75 µg/dL.\"},{\"question\":\"Which factors were independently associated with copper deficiency at 6 months?\",\"answer\":\"In adjusted analyses, female sex and greater 6-month percent total weight loss (%TWL) were independently associated with copper deficiency at 6 months; age and procedure type were not.\"}]","Trends of copper deficiency following one anastomosis gastric bypass and Roux-en-Y gastric bypass | PDF",1790750192,23]