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Regional and stage-specific shifts show higher northern rates and more stage I–II with reduced stage III–IV.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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Submission:05/05/2024 Acceptance:09/23/2024  \nTrends in Stage-Specific Kidney Cancer Incidence in Kazakhstan, 2005-2019  \nNurbek Igissin 1,2,3 , Sergey Dyakov 2,4,5 , Zhansaya Telmanova 2 , Indira Kudaibergenova3,5, Serik Ayaganov6, Dulat Turebayev2,7, Akzhunis Jexenova7, Gulnur S Igissinova 2,8 , Saule Maukayeva 9 , Vladimir Lyust 7 , Vladimir Grigorevskiy 7, Alina Shelestyuk7, Nariman Syzdykov2,10, Ivan Shishkin 6, Zarina Bilyalova2,3 *  \nAbstract  \nObjective: The aim is to analyze the incidence of kidney cancer over a 15-year period, considering factors such as stage, age, sex, and morphological verification in the regional context in Kazakhstan. Methods: The retrospective study was done using descriptive and analytical methods of oncoepidemiology. The extensive, crude and age-specific incidence rates are determined according to the generally accepted methodology used in sanitary statistics. The data were used to calculate the average percentage change (APС) using the Joinpoint regression analysis to determine the trend over the study period. Results: Among the meticulously documented 15,277 cases, a conspicuous male predominance was noted, comprising 53.7% of cases compared to 46.3% in females, with peak incidences observed within the 50-69 age cohorts. The average age at diagnosis exhibited a progressive rise over the study period, with discernible variations observed in age-specific incidence rates, particularly pronounced within the 60-84 age brackets. Noteworthy temporal trends indicated a consistent uptick in crude incidence rates, with distinct regional disparities manifesting higher rates in northern regions relative to their southern and western counterparts. Stratification by cancer stage unveiled a significant surge in stages I-II cases alongside a concomitant decrement in stage III incidences, complemented by reductions in stage IV occurrences and instances of unspecified disease stages. Morphological verification rates displayed regional variations, with an overarching ascending trajectory across most regions, albeit exceptions noted, notably in the Kyzylorda region. Conclusion: Our study identified a rise in kidney cancer incidence in Kazakhstan, likely reflecting global trends driven by increased risk factor exposure and incidental imaging findings. Regional disparities and varied stage distributions highlight the complexity of kidney cancer epidemiology. Despite advancements in early detection, delayed diagnosis persists, necessitating improved surveillance and diagnostic practices.  \nKeywords: Renal cancer-cancer rate-dynamics-morphological verification-regions  \nAsian Pac J Cancer Prev, 25 (9), 3239-3249  \nIntroduction  \nIn 2022, approximately 434,840 new cases of kidney cancer were documented globally, ranking it 14th in the hierarchy of oncological pathologies. Additionally, it occupied the 16th position concerning mortality, with 155,953 deaths attributed to this malignant neoplasm [1] . The global incidence of kidney cancer is on the rise, with the most pronounced increases documented in developed  \nnations [2]. Well-established risk determinants for kidney cancer comprise advancing age, male gender, tobacco usage, hypertension, and obesity [3] .  \nDiagnosing kidney cancer poses a considerable challenge duetothe elusive nature of renal cell carcinomas, which account for approximately 85% of kidney cancers [4] . Traditionally, the clinical presentation of kidney cancer was associated with a triad of symptoms, including hematuria, pain, and the presence of an abdominal mass  \n1Research Institute of Life and Health Sciences, Higher School of Medicine, Kokshetau University named after Sh. Ualikhanov, Kokshetau, Kazakhstan. 2Central Asian Institute for Medical Research, Astana, Kazakhstan. 3Asian Pacific Organization for Cancer Prevention, Bishkek, Kyrgyzstan. 4National Scientific Center of Traumatology and Orthopedics named after Academician Batpenov N.D. of the Minist","cbCaifKLTBiNY6tZ","https://ap.wps.com/l/cbCaifKLTBiNY6tZ","pdf",909642,11,"English","# Abstract\n# Introduction\n# Objective\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What is the main objective of the study on kidney cancer incidence in Kazakhstan?\",\"answer\":\"To analyze kidney cancer incidence over 2005–2019 by stage, age, sex, and morphological verification in Kazakhstan’s regional context.\"},{\"question\":\"How were incidence trends calculated in the study?\",\"answer\":\"Crude and age-specific incidence rates were determined using accepted sanitary statistics methods, and trends were evaluated with Joinpoint regression using average percentage change.\"},{\"question\":\"What key demographic and regional patterns were reported?\",\"answer\":\"Male incidence predominated (53.7% vs 46.3% females), peaks were most common in ages 50–69, and crude incidence increased over time with higher rates in northern regions than southern and western regions.\"}]","Trends in Stage-Specific Kidney Cancer Incidence in Kazakhstan - 2005-2019 | PDF",1789999982,28]