[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332382-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332382-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","trends-in-hpv-associated-cancer-incidence-in-texas-medically-underserved-regions","Trends in HPV-associated cancer incidence in Texas medically underserved regions","","HPV-associated cancer incidence in Texas shows shifting patterns as cervical cancer rates decline while non-cervical HPV-driven cancers rise. The study examines cancer incidence rates (IR) from 2006–2019 in East Texas and the TX–Mexico Border versus other Texas regions, focusing on medically underserved populations with elevated risk. Using Texas Cancer Registry data and county-level behavioral and access factors, the analysis maps county variation and estimates unadjusted and adjusted risk ratios.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/trends-in-hpv-associated-cancer-incidence-in-texas-medically-underserved-regions/332382/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/trends-in-hpv-associated-cancer-incidence-in-texas-medically-underserved-regions/332382.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main objective of the study in Texas regions?","Question",{"text":63,"@type":64},"To investigate incidence rates of HPV-associated cancers, including non-cervical cancers, across different Texas regions, with emphasis on East Texas and the TX–Mexico Border.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which cancer types and data sources were included?",{"text":68,"@type":64},"The study included HPV-associated cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers using 2006–2019 cancer data from the Texas Cancer Registry, along with patient-level demographics.",{"name":70,"@type":61,"acceptedAnswer":71},"How were incidence rates and regional differences analyzed?",{"text":72,"@type":64},"Incidence rates per 100,000 were calculated, county heat maps were created, and county-level risk factors were added to estimate unadjusted and adjusted risk ratios by region and time.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332382,1790217345,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","DOI: 10. 1002/cam4 .70133  \nRESEAR CH ARTICLE  \nTrends in HPV-associated cancer incidence in Texas medically underserved regions  \nThao N. Hoang1  | Abbey B. Berenson2,3  | Yong Shan4 | Fangjian Guo2,3  | Victor Adekanmbi2,3 | Christine Hsu2,3 | Xiaoying Yu4 | Yong-Fang Kuo4  \n1Institute for Translational Sciences, University of Texas Medical Branch, Galveston, Texas, USA  \n2Center for Interdisciplinary Research in Women's Health, University of Texas Medical Branch, Galveston, Texas, USA 3Department of Obstetrics and Gynecology, The University of  \nTexas Medical Branch at Galveston, Galveston, Texas, USA 4Department of Biostatistics and Data Science, University of Texas Medical  \nBranch, Galveston, Texas, USA  \nCorrespondence  \nThao N. Hoang, BS, Institute for Translational Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA. Email: [thnhoang@utmb.edu](thnhoang@utmb.edu)  \nFunding information  \nAgency for Healthcare Research and Quality, Grant/Award Number:  \nT32HS026133; Cancer Prevention and Research Institute of Texas, Grant/Award Number: RP210130; National Institute of Arthritis and Musculoskeletal and Skin Diseases, Grant/Award Number: K12AR084228- 20S1; National Institutes of Health, Grant/Award Number: K12AR084228  \nAbstract  \nBackground: While cervical cancer incidence rates (IR) in the United States have dropped in the last 20 years, non-cervical human papillomavirus (HPV) associated cancers increased. Many people in Texas (TX) live in medically underserved areas and have higher risk of developing HPV-associated cancers. Since previous studies of these regions focused on cervical cancer, we included other HPV-associated cancers in our analysis of IR in East TX and the TX-Mexico Border compared to other TX regions.  \nMethods: Cancer data from 2006 to 2019 were obtained from the TX Cancer Registry. Cases of HPV-associated cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers and corresponding patient-level demographic data were included. We calculated IR per 100,000 and drew heat maps to visualize cancer IR by county. To control potential confounders, we added county-level risk factors: rates for smoking, excessive drinking, obesity, STIs, primary care provider availability and dentist availability, from the County Health Rankings and Roadmaps program. We reported IRs by region and time and estimated unadjusted and adjusted risk ratio (RR) for association of each type of cancer and region. Lastly, we created adjusted models for each cancer by period to see time trends of regional differences. Results: Risk of anal, cervical, and oropharyngeal cancer was lower at parts of the Border than in the rest of TX in the adjusted model. We also observed increasing anal and oropharyngeal cancer risk and decreasing cervical and vaginal cancer risk over time.  \nConclusion: Patient sociodemographics, behavioral risk factors, and access to care may contribute to some observed differences in cancer IR across regions. This indicates that targeted prevention efforts towards these regions, especially in low socioeconomic status communities, may benefit future generations.  \nKEYWORDS  \ndisparities, epidemiology, human papillomavirus  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.  \nCancer Medicine. 2024;13:e70133 .  \n[https://doi.org/10.1002/cam4.70133](https://doi.org/10.1002/cam4.70133)  \n[wileyonlinelibrary.com/journal/cam4](wileyonlinelibrary.com/journal/cam4)  \n1 of 10  \n1 | INTRODUCTION  \nHuman papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the United States (US) .1 While most HPV infections are cleared naturally by a cell-mediated immune response, some infections persist and can lead to precancerous lesions and later, ca","cbCaipC6PIDsJs66","https://ap.wps.com/l/cbCaipC6PIDsJs66","pdf",6146494,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction\n## HPV infection and cancer risk\n## Trends in incidence in the United States\n## Texas regional disparities and research gap","[{\"question\":\"What was the main objective of the study in Texas regions?\",\"answer\":\"To investigate incidence rates of HPV-associated cancers, including non-cervical cancers, across different Texas regions, with emphasis on East Texas and the TX–Mexico Border.\"},{\"question\":\"Which cancer types and data sources were included?\",\"answer\":\"The study included HPV-associated cervical, vaginal, vulvar, penile, anal, and oropharyngeal cancers using 2006–2019 cancer data from the Texas Cancer Registry, along with patient-level demographics.\"},{\"question\":\"How were incidence rates and regional differences analyzed?\",\"answer\":\"Incidence rates per 100,000 were calculated, county heat maps were created, and county-level risk factors were added to estimate unadjusted and adjusted risk ratios by region and time.\"}]","Trends in HPV-associated cancer incidence in Texas medically underserved regions | PDF",1789997920,25]