[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-146124-105":59,"doc-detail-146124-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","trends-in-cancer-research-vol-12-2017","Trends in Cancer Research - Vol. 12 - 2017","","Endometriosis increases the later-life risk of ovarian cancer, yet the histogenesis of endometriosis-associated ovarian cancer (EAOC) remains unresolved. This review summarizes English-language literature from 2000 to 2017, focusing on genetic background and proposed origins. Oxidative stress, inflammation, immune responses, and hormone-related deregulated pathways are linked to EAOC carcinogenesis. Evidence suggests ovarian endometrioid carcinoma and clear cell carcinoma share inflammatory and oxidative sensitivity and may be driven by epigenetically regulated histogenesis markers, with secretory and ciliated cells proposed as origins.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/trends-in-cancer-research-vol-12-2017/146124/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/trends-in-cancer-research-vol-12-2017/146124.png","ImageObject",300,407,{"name":92,"@type":93},"Jordan Avery","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-08-26",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What key factors are associated with the malignant transformation of endometriosis in EAOC?","Question",{"text":113,"@type":114},"Oxidative stress, inflammatory/immune response, and hormone activity are highlighted as associated with malignant transformation in multiple studies.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What relationship is proposed between ovarian endometrioid carcinoma and clear cell carcinoma?",{"text":118,"@type":114},"They show similar responses to inflammatory and oxidative stimuli and share a common genetic abnormality, suggesting potentially related origins.",{"name":120,"@type":111,"acceptedAnswer":121},"Which cell types are proposed as candidates for the origin of different EAOC subtypes?",{"text":122,"@type":114},"Secretory cells are candidates for ovarian endometrioid carcinoma, while ciliated cells are candidates for clear cell carcinoma.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},146124,1787736840,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":130,"read_time":144},1099523882367,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","| T r e n d s i n C a n c e r R e s e a r c h |\n| --- |\n| Vol. 12, 2017 |\n\nHistogenesis of endometriosis-associated ovarian cancer Hiroshi Kobayashi*, Sachiko Morioka, Kana Iwai, Emiko Niiro, Mai Kimura, Hajime Fujii and Sumire Sugimoto  \nDepartment of Obstetrics and Gynecology, Nara Medical University, Nara, Japan.  \nABSTRACT  \nPatients with endometriosis carry the potential risk for ovarian cancer later in life, but the histogenesis of endometriosis-associated ovarian cancer (EAOC) still remains unclear. This review outlines recent advances in the understanding of the genetic background and histogenesis of EAOC. This article reviews the English-language literature between 2000 and 2017. The oxidative stress, inflammation, immune response and hormone activity are mainly associated with deregulated pathways contributing to the carcinogenesis of EAOC. Ovarian endometrioid carcinoma (EC) and clear cell carcinoma (CCC) respond similarly to inflammatory and oxidative stimuli and share a common genetic abnormality. Several markers of histogenesis have been used to assess whether EC and CCC arise from the same clone or different precursor cells. Expression of various histogenesis markers may be epigenetically regulated in distinct EAOC subtypes. Secretory cells and ciliated cells in endometriosis are candidates for cells of origin of EC and CCC, respectively. In conclusion, EAOC may arise from the different precursor cells that undergo similar genetic changes.  \nKEYWORDS: endometriosis, malignant secretory cells, transformation, ciliated cells, epigenetics.  \nINTRODUCTION  \nEndometriosis is a common, chronic inflammatory disease that affects ~10% of women at reproductive age [1] . Endometriosis is defined as the ectopic  \n*[Corresponding author: hirokoba@naramed-u.ac.jp](Corresponding author: hirokoba@naramed-u.ac.jp)  \nimplantation of endometrial glands and stroma outside the uterine endometrium [2, 3]. The common symptoms of this disease are dysmenorrhea, dyspareunia, chronic pelvic pain and/or infertility [1, 4] . Epidemiological studies have demonstrated that endometriosis is a risk factor for some types of malignancies, especially for uterine and ovarian endometrioid carcinoma (EC), clear cell carcinoma (CCC), low-grade serous carcinoma and seromucinous neoplasms [5, 6] . Endometriosis was found in approximately 20% of EC and CCC patients and present adjacent to the tumor [7, 8]. Approximately 1% of ovarian endometrioma gives rise to endometriosis-associated ovarian carcinoma (EAOC)  \n[8]. Elegant studies have focused on the pathogenesis of EAOC [9, 10] . EAOC is thought to develop in at least two distinct environmental phases. CCC develops primarily during obvious oxidative stress associated with elevation of antioxidant content, while EC occurs during an estrogenic mode of action due to the observed induction of estrogen receptor (ER) [10, 11] . Both tumors frequently occur in perimenopausal and/or early postmenopausal women. The origin of the precursor cells has been attributed to normal endometrium, fallopian tube epithelium, or cortical inclusion cyst (CIC) with Müllerian metaplasia [12-15] . The eutopic and ectopic endometrium are composed of at least two cell types with unique properties, secretory cells and ciliated cells. Presence of endometriosis is associated with an increased risk of ovarian cancer later in life, but the histogenesis of EAOC still remains unclear. Two existing theories or postulations are eligible for consideration: 1) the pluripotent stem cells may possess the ability to replenish EC and CCC, securing multilineage differentiation and  \nreconstitution, and 2) the EAOC dichotomy is probably due to the origin of cancer from different precursor cells in endometriosis. Here we seek to present the current state of knowledge regarding the genetic background and histogenesis of EAOC.  \nMATERIALS AND METHODS  \nSystematic review of the literature was done using electronic search in the PubMed/Medline databas","cbCaiipnLdbCHFA1","https://ap.wps.com/l/cbCaiipnLdbCHFA1","pdf",176407,"English","# Abstract\n# Introduction\n# Materials and Methods\n# Results\n## A background for malignant transformation of endometriosis","[{\"question\":\"What key factors are associated with the malignant transformation of endometriosis in EAOC?\",\"answer\":\"Oxidative stress, inflammatory/immune response, and hormone activity are highlighted as associated with malignant transformation in multiple studies.\"},{\"question\":\"What relationship is proposed between ovarian endometrioid carcinoma and clear cell carcinoma?\",\"answer\":\"They show similar responses to inflammatory and oxidative stimuli and share a common genetic abnormality, suggesting potentially related origins.\"},{\"question\":\"Which cell types are proposed as candidates for the origin of different EAOC subtypes?\",\"answer\":\"Secretory cells are candidates for ovarian endometrioid carcinoma, while ciliated cells are candidates for clear cell carcinoma.\"}]","Trends in Cancer Research - Vol. 12 - 2017 | PDF",23]