[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-378490-105":59,"doc-detail-378490-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","treatment-trends-in-brain-metastases-from-testicular-cancer-in-the-united-states","Treatment trends in brain metastases from testicular cancer in the United States","","Treatment trends for brain metastases arising from primary testicular cancers are characterized using the National Cancer Database. Patient records from 2010 to 2015 were analyzed among those treated with brain-directed radiation. Multivariable logistic regression identified predictors of treatment type, while Cox regression assessed predictors of overall survival. Most patients received whole brain radiation rather than stereotactic radiosurgery (SRS). Improved survival was associated with age, private insurance, chemotherapy, and SRS, with the 5-year survival rate highest after SRS. Study limitations include lack of tumor size and dose details.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/treatment-trends-in-brain-metastases-from-testicular-cancer-in-the-united-states/378490/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/treatment-trends-in-brain-metastases-from-testicular-cancer-in-the-united-states/378490.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What data source was used to study treatment trends for brain metastases from testicular cancer?","Question",{"text":112,"@type":113},"The study used the National Cancer Database (NCDB) to describe treatment trends in patients with primary testicular cancers and brain metastases treated with brain-directed radiation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which treatment was most commonly received by patients in the study?",{"text":117,"@type":113},"Most patients received whole brain radiation therapy rather than stereotactic radiosurgery (SRS).",{"name":119,"@type":110,"acceptedAnswer":120},"What factors were associated with improved overall survival, and how did SRS compare to whole brain radiation?",{"text":121,"@type":113},"Improved survival predictors included age, private insurance coverage, receipt of chemotherapy, and receipt of SRS. The 5-year survival rate was highest for patients who received SRS, and the study concludes SRS significantly improves overall survival compared with whole brain radiation therapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378490,1790318332,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","Research Article  \nFor reprint orders, please contact: [reprints@futuremedicine.com](reprints@futuremedicine.com)  \nTreatment trends in brain metastases from testicular cancer in the United States  \nJoseph Crooks*,1, Matthew Shepard2 & Rodney E Wegner3  \n1 Drexel University College of Medicine, Philadelphia, PA 19129, USA  \n2Allegheny Health Network, Department of Neurosurgery, Pittsburgh, PA 15212, USA  \n3Allegheny Health Network Cancer Institute, Division of Radiation Oncology, Pittsburgh, PA 15212, USA  \n*Author for correspondence: Tel.: +1 215 510 3113; [jcc453@drexel.edu](jcc453@drexel.edu)  \nAim: We utilized the National Cancer Database to describe the treatment trends in brain metastases from primary testicular cancers. Methods: We analyzed data from the NCDB from 2010 to 2015 for patients with both primary testicular cancers and brain metastases who were treated with brain-directed radiation. We performed multivariable logistic and cox regressions to identify predictors of treatment type and overall survival respectively. Results: Most patients meeting the above criteria received whole brain radiation therapy as opposed to stereotactic radiosurgery (SRS) . Predictors of improved survival were age, private insurance coverage, receipt of chemotherapy, and receipt of SRS. The 5-year survival rate was highest for patients who received SRS. Conclusion: This study confirms significantly improved overall survival with the use of SRS.  \nPlain language summary: Testicular cancer is quite rare, making up just 1% of solid cancers found in men every year. Even rarer is the situation where this cancer spreads to the brain. When this happens, it can be treated in a few different ways: surgery, radiation to the entire brain, a focused type of radiation called stereotactic radiosurgery, or a combination of these methods. Due to its rarity, there isn’t a clear-cut best approach for treating these brain tumors. In our research, we used a massive database, the National Cancer Database (NCDB), to get a clearer picture of this issue. We looked at patients diagnosed with testicular cancer between 2004 and 2015 who also had at least one tumor in the brain. By analyzing this information, we could compare the survival outcomes of patients based on the type of treatment they received and other factors.  \nWe found that brain tumors from testicular cancer are very rare, found in just 0.4% of the patients we studied. We also found that treatment with either focused radiation, whole brain radiation, or chemotherapy significantly improves survival rates compared with no treatment. In addition, focused radiation, called stereotactic radiosurgery, might result in even better survival results than radiation to the entire brain. Receiving this focused radiation was more common in patients who also had tumorsin other parts of their body. While our study gives essential insights, it does have some limitations. The database we used doesn’t provide specific details like the size of the brain tumors, the exact treatment doses, and some other crucial patient information. This means that while we now have a better overall picture, more research is needed to give patients and doctors a complete understanding.  \nTweetable abstract: Utilizing the National Cancer Database (2010–15), our study on brain metastases from testicular cancers reveals SRS improves overall survival more than whole brain radiation therapy.  \nFirst draft submitted: 9 April 2023; Accepted for publication: 16 August 2023; Published online:  \n31 August 2023  \nKeywords: brain metastases • radiation therapy • stereotactic radiosurgery • testicular cancer  \nCancers of testicular origin are quite rare, accounting for 1% of solid male cancers annually, with an exceptional fiveyear survival rate often surpassing 95%[1] . Even more rare is the presence or development of brain metastases from a primary testicular cancer, a situation which shifts both prognosis and treatment options. Treatment options fo","cbCaiojUGzh4BIhB","https://ap.wps.com/l/cbCaiojUGzh4BIhB","pdf",904215,"English","# Aim\n## Methods\n## Results\n## Conclusion\n# Plain language summary\n## Treatment options and study approach\n## Key findings and limitations\n# Tweetable abstract\n# Keywords\n# Introduction\n## Background and rationale\n# Materials & methods","[{\"question\":\"What data source was used to study treatment trends for brain metastases from testicular cancer?\",\"answer\":\"The study used the National Cancer Database (NCDB) to describe treatment trends in patients with primary testicular cancers and brain metastases treated with brain-directed radiation.\"},{\"question\":\"Which treatment was most commonly received by patients in the study?\",\"answer\":\"Most patients received whole brain radiation therapy rather than stereotactic radiosurgery (SRS).\"},{\"question\":\"What factors were associated with improved overall survival, and how did SRS compare to whole brain radiation?\",\"answer\":\"Improved survival predictors included age, private insurance coverage, receipt of chemotherapy, and receipt of SRS. The 5-year survival rate was highest for patients who received SRS, and the study concludes SRS significantly improves overall survival compared with whole brain radiation therapy.\"}]","Treatment trends in brain metastases from testicular cancer in the United States | PDF",1790230299,23]