[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-167356-105":59,"doc-detail-167356-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","treatment-of-malignant-fibrous-histiocytoma-and-atypical-fibrous-xanthomas-with-micrographic-surgery-honorary-mention","Treatment of Malignant Fibrous Histiocytoma and Atypical Fibrous Xanthomas with Micrographic Surgery - Honorary Mention","","Fibrous tumors of soft tissue are usually benign, but some fibrous neoplasms such as dermatofibrosarcoma protuberans (DFSP), atypical fibroxanthoma (AFX), and malignant fibrohistiocytoma (MFH) can be locally destructive with frequent recurrence after local excision, and on occasion may metastasize. Prior reports support Mohs micrographic surgery for DFSP, while data were limited for MFH and AFX. Over six years, Mohs surgery was used for 17 MFH patients (20 tumors) and 5 AFX patients. Retrospective analysis showed tumor-free status for all contacted patients at average three-year follow-up, with only one recurrence and no metastatic disease, supporting Mohs as an effective approach for difficult-to-cure tumors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/treatment-of-malignant-fibrous-histiocytoma-and-atypical-fibrous-xanthomas-with-micrographic-surgery-honorary-mention/167356/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/treatment-of-malignant-fibrous-histiocytoma-and-atypical-fibrous-xanthomas-with-micrographic-surgery-honorary-mention/167356.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-18","2026-08-31",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are DFSP, MFH, and AFX considered clinically challenging?","Question",{"text":112,"@type":113},"They can behave aggressively locally, with high recurrence after simple local excision. DFSP has invasive growth and may metastasize rarely, while MFH has significant metastatic risk and AFX is more superficial with low metastatic potential.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many patients and tumors were treated with Mohs micrographic surgery?",{"text":117,"@type":113},"Over six years, 17 patients with MFH (20 tumors) and 5 patients with AFX were treated, for a total of 22 patients and 25 neoplastic fibrohistiocytic tumors.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main outcomes after treatment?",{"text":121,"@type":113},"At average three-year follow-up, all contacted patients were tumor free except one recurrence. No patient developed metastatic disease.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},167356,1788212068,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":143},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Abstract.Fibrous tumors of the soft tissue are usuallybenign,but some tibrous neoplasms such as dermatofi-brosarcoma protuberans(DFSP),atypical fibroxanthoma(AFX),and malignant fibrohistiocytoma(MFH)can bevery destructive locally with a high recurrence rate afterlocal excision.On occasion,they can metastasize.Pre-vious reports have confirmed the high success rate ofMohs micrographic surgery for the treatment of DFSP,but data have been lacking on the potential benefit of thissurgical approach for MFH and AFX tumors.Over thepast 6 years,we have treated 17 patients with MFH(20tumors)and 5 patients with AFX with Mohs micrographicsurgery.A retrospective analysis of the surgical resultsis presented.To date(average 3-year follow-up),all pa-tients contacted are tumor free with only one recurrence;no patient has developed metastatic disease.Our resultsto date are very encouraging;they lend support to Mohsmicrographic surgery as a desired surgical approach forthese diffiult-to-cure neoplasms.J Dermatol Surg Oncol1989;15:1287-1292.  \n# INTRODUCTION\n\nFibrohistiocytic tumors are a large and heteroge-neous group of soft-tissue neoplasms that are sim-ilar in their composition to cells resembling fibro-blasts and histiocytes.The histogenesis of these  \n\n| Treatment of Malignant Fibrous  \u003Cbr>Histiocytoma and Atypical  \u003Cbr>Fibrous Xanthomas with  \u003Cbr>Micrographic Surgery  \u003Cbr>MARC D.BROWN,M.D.·NEIL A.SWANSON,M.D.   | HONORABLE  \u003Cbr>MENTION   |\n| --- | --- |\n\ntumors is uncertain,but they probably arise frommesenchymal cells that show partial histiocytic and/or fibroblastic differentiation.1,2 The more malig-nant of these tumors retain some degree of pleu-ropotentiality.  \nFibrohistiocytic tumors can be classified accord-ing to their malignant potential.The most commonfibrohistiocytic neoplasm is the benign dermatofi-broma,which has no invasive or malignant char-acteristics and rarely requires surgical intervention.Dermatofibrosarcoma protuberans(DFSP)is con-sidered a fibrohistiocytic sarcoma of intermediatemalignancy.It bears a striking histologic similarityto the benign fibrous histiocytoma,but grows in amore infiltrative fashion,has a more markedtendency for local recurrence,and in rare instancescan metastasize.3,4 For this reason,DFSP was firstdescribed in 1924 as a \"progressive and recurringdermatofibroma.\"5  \nThe malignant fibrous histiocytoma(MFH)mayresemble a DFSP histologically but also shows nu-merous atypical mitotic figures and marked pleo-morphic cellularity.In addition to a high local re-currence rate,there is a significant metastatic rateusually associated with a poor prognosis.6,7Prog-nosis and survival appears in part to be related totumor depth.  \nThe atypical fibroxanthoma(AFX)is probably themost superficial or limited form of an MFH.Becauseof its superficial,intradermal location,it pursues arelatively benign course with a low recurrence rateand practically no metastatic potential.8  \nThe surgical management of these malignant fi-brohistiocytic tumors has been problematic andcontroversial due to the high recurrence rate,ag-gressive local infiltration,and metastatic potential.  \nThe surgical process of treating DFSP with Mohsmicrographic surgery has been well described inprevious reports.At least 6 articles have appearedin the literature attesting to a high cure rate in atotal of 26 patients.9-14 In addition,we have treated13 patients with DFSP using Mohs surgery (unpub-lished data)with no recurrences.It has been estab-lished that Mohs surgery is a preferred surgical mo-dality for DFSP.As Hanke¹³states,'The limitationsof standard vertical section histology may contrib-ute to recurrences of DFSP even when wide exci-sional margins were used.The microscopic exten-sions of DFSP can be easily traced out with Mohsmicrographic surgery.DFSP should be considereda clear cut indication for Mohs micrographicsurgery.\"  \nHowever,the treatment of other neoplastic fi-brohistiocytic tumors(MFH and AFX)with Mohssurgery has not been as well establ","cbCaifmMgoXdDrmp","https://ap.wps.com/l/cbCaifmMgoXdDrmp","pdf",832522,"English","# Introduction\n# Materials and Methods\n## Patient cohort and tumor distribution\n## Surgical technique and margin assessment\n## Staging, sections, and defect size","[{\"question\":\"Why are DFSP, MFH, and AFX considered clinically challenging?\",\"answer\":\"They can behave aggressively locally, with high recurrence after simple local excision. DFSP has invasive growth and may metastasize rarely, while MFH has significant metastatic risk and AFX is more superficial with low metastatic potential.\"},{\"question\":\"How many patients and tumors were treated with Mohs micrographic surgery?\",\"answer\":\"Over six years, 17 patients with MFH (20 tumors) and 5 patients with AFX were treated, for a total of 22 patients and 25 neoplastic fibrohistiocytic tumors.\"},{\"question\":\"What were the main outcomes after treatment?\",\"answer\":\"At average three-year follow-up, all contacted patients were tumor free except one recurrence. No patient developed metastatic disease.\"}]","Treatment of Malignant Fibrous Histiocytoma and Atypical Fibrous Xanthomas with Micrographic Surgery - Honorary Mention | PDF",15]