[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-421329-105":59,"doc-detail-421329-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","translating-senolytics-from-mice-to-humans","TRANSLATING SENOLYTICS FROM MICE TO HUMANS","","Translating senolytics from rodent studies into human interventions is a focus for improving healthspan and potentially lifespan. Evidence from extensive rodent research shows senescent cells accumulate across tissues and that their clearance improves health outcomes. ClinicalTrials.gov indicates numerous ongoing studies for senolytics and fisetin, yet only a limited number of published senolytics trials exist, with few including control groups. Current results suggest biological efficacy of dasatinib plus quercetin for healthspan biomarkers, while also emphasizing heterogeneity in aging mechanisms and the need for more personalized trial approaches.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/translating-senolytics-from-mice-to-humans/421329/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/translating-senolytics-from-mice-to-humans/421329.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main goal of translating senolytics from mice to humans?","Question",{"text":113,"@type":114},"To apply findings from rodent research to improve human healthspan and potentially lifespan through senescent cell clearance.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How many senolytics trials have been published, and how many included control groups?",{"text":118,"@type":114},"There are 9 published clinical trials of senolytics, and only 2 of them included a control group.",{"name":120,"@type":111,"acceptedAnswer":121},"What early efficacy signal do senolytics trials suggest?",{"text":122,"@type":114},"Initial findings indicate possible biological efficacy of dasatinib plus quercetin for improving human healthspan biomarkers without significant safety concerns.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},421329,1791000649,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":81,"preview_page_count":4},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Innovation in Aging, 2025, Vol. 9, No. S2 203  \nin humans and argue for a more personalized approach in futuresenolytic trials. Specifically, it is likely going to be critical to identify aging individuals with a sufficiently high burden of senescent cells that would result in a beneficial effect from the senolytic intervention.  \nAbstract citation ID: igaf122.679  \nTRANSLATING SENOLYTICS FROM MICE TO HUMANS  \nSundeep Khosla, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, United States  \nExtensive studies in rodents have shown that senescent cells accumulate across tissues and their clearance leads to improvements in healthspan and lifespan. Based on these studies, thereis intense interest in translating these findings into humans. Based [on ClinicalTrials.gov](on ClinicalTrials.gov), there are currently 26 ongoing studies on“senolytics”and 32 on “fisetin”. However, to date, there are only  \n9 published clinical trials of senolytics, only 2 of which included a control group. Collectively, the initial findings from these trials have indicated possible biological efficacy of senolytics (dasatinib + quercitin) in improving biomarkers of healthspan in humans with no significant safety concerns. However, these initial studies also highlight the potential heterogeneity of aging mechanisms","cbCaigdTFRZGFyuG","https://ap.wps.com/l/cbCaigdTFRZGFyuG","pdf",234870,"English","# Background and rationale\n## Clinical trial landscape and evidence limits\n## Initial results and safety considerations\n## Need for personalization and aging heterogeneity","[{\"question\":\"What is the main goal of translating senolytics from mice to humans?\",\"answer\":\"To apply findings from rodent research to improve human healthspan and potentially lifespan through senescent cell clearance.\"},{\"question\":\"How many senolytics trials have been published, and how many included control groups?\",\"answer\":\"There are 9 published clinical trials of senolytics, and only 2 of them included a control group.\"},{\"question\":\"What early efficacy signal do senolytics trials suggest?\",\"answer\":\"Initial findings indicate possible biological efficacy of dasatinib plus quercetin for improving human healthspan biomarkers without significant safety concerns.\"}]","TRANSLATING SENOLYTICS FROM MICE TO HUMANS | PDF",1790624624]