[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426372-105":59,"doc-detail-426372-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","translating-basic-biology-of-aging-into-treatments-to-increase-human-healthspan-translational-strategies-and-challenges","Translating Basic Biology of Aging Into Treatments to Increase Human Healthspan - Translational strategies and challenges","","Focuses on translating basic biology of aging into therapies that increase human healthspan, emphasizing proteostatic mechanisms in mitochondria to enhance stress resistance and slow aging. Prioritizes skeletal muscle to mitigate age-associated sarcopenia and applies stable-isotope approaches suited to pre-clinical models and human studies. Highlights the use of D2O to quantify synthesis of proteins, DNA, and RNA across cells, yeast, C. elegans, rodents, canines, and humans, covering training, reverse-translation, and recruitment and retention challenges.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/translating-basic-biology-of-aging-into-treatments-to-increase-human-healthspan-translational-strategies-and-challenges/426372/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/translating-basic-biology-of-aging-into-treatments-to-increase-human-healthspan-translational-strategies-and-challenges/426372.png","ImageObject",300,407,{"name":92,"@type":93},"Aran","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main research goal described in the abstract?","Question",{"text":112,"@type":113},"To translate basic biology of aging into treatments that increase human healthspan by slowing aging processes and improving stress resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why does the research focus on skeletal muscle?",{"text":117,"@type":113},"To minimize age-associated sarcopenia, with skeletal muscle serving as a primary tissue target for the translation work.",{"name":119,"@type":110,"acceptedAnswer":120},"What stable isotope approach is highlighted as particularly useful?",{"text":121,"@type":113},"D2O is highlighted as useful for measuring synthetic processes of protein, DNA, and RNA to address both basic and translational questions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426372,1790741774,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},137455076865,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","326 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1100  \nTRANSLATING BASIC BIOLOGY OF AGING INTO TREATMENTS TO INCREASE HUMAN HEALTHSPAN  \nBenjamin Miller, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States  \nThe focus of the Miller lab is to translate basic biology of aging into treatments to increase human healthspan. We focus on proteostatic mechanisms in mitochondria to increase stress resistance for slowing aging.These studies concentrate primarily on skeletal muscle to minimize age-associated sarcopenia. We use stable isotope approaches that are amenable to both pre-clinical models and human subjects as a primary means to translate findings from the basic biology of aging to clinical implementation. Particularly useful has been the isotope D2O that we use to measure synthetic processes of protein, DNA, andRNAto answer basic and translational questions in relevant aging models including cells, yeast, C. elegans, rodents, canines, and humans. In this session, I will discuss how I sought training to allow me to perform translational work and the skillsets needed to be able to bridge pre-clinical to clinical work. I will also discuss how our clinical work informs our more mechanistic experiments as “reverse-translation”. Finally, I will present the challenges we have faced while performing work along the translational spectrum, and strategies we have used to successfully recruit and retain subjects in studies that require tissue sampling.","cbCaimITON7zwXbM","https://ap.wps.com/l/cbCaimITON7zwXbM","pdf",335585,"English","# Abstract\n## Research focus and translation strategy\n## Stable isotope methods and D2O applications\n## Training, reverse-translation, and operational challenges","[{\"question\":\"What is the main research goal described in the abstract?\",\"answer\":\"To translate basic biology of aging into treatments that increase human healthspan by slowing aging processes and improving stress resistance.\"},{\"question\":\"Why does the research focus on skeletal muscle?\",\"answer\":\"To minimize age-associated sarcopenia, with skeletal muscle serving as a primary tissue target for the translation work.\"},{\"question\":\"What stable isotope approach is highlighted as particularly useful?\",\"answer\":\"D2O is highlighted as useful for measuring synthetic processes of protein, DNA, and RNA to address both basic and translational questions.\"}]","Translating Basic Biology of Aging Into Treatments to Increase Human Healthspan - Translational strategies and challenges | PDF",1790640355]