[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-289876-105":59,"doc-detail-289876-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","transfusion-and-apheresis-science-63-2024-103864-article","Transfusion and Apheresis Science 63 (2024) 103864 - Article","","Study evaluates diagnostic performance of immunohematological tests for assessing prevalence of ABO hemolytic disease of the newborn (HDN) in antenatal O group mothers and related neonatal outcomes in a tertiary care hospital in Northern India. Included 213 O group mothers and 122 ABO-incompatible newborns. Maternal IgG anti-A/anti-B titers were measured by Conventional Tube Technique using DTT, with follow-up after delivery. ABO-HDN prevalence, test parameters, correlations, and predictive value of maternal titer and DAT guided conclusions.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/transfusion-and-apheresis-science-63-2024-103864-article/289876/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/transfusion-and-apheresis-science-63-2024-103864-article/289876.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-18","2026-09-17",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition does the study focus on?","Question",{"text":112,"@type":113},"The study focuses on hemolytic disease of the newborn (HDN), specifically ABO-HDN, in O group mothers and their ABO-incompatible newborns.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were maternal antibody levels measured in the study?",{"text":117,"@type":113},"Maternal IgG anti-A/anti-B antibody titers were quantified using the Conventional Tube Technique (CTT) with Dithiothreitol (DTT) pretreated maternal serum.",{"name":119,"@type":110,"acceptedAnswer":120},"Which tests were compared for diagnostic performance?",{"text":121,"@type":113},"The study compares immunohematological tests including maternal IgG titers, Direct Antiglobulin Test (DAT), and hemolysin testing to assess diagnostic parameters and neonatal outcomes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},289876,1789638115,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":143,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Transfusion and Apheresis Science 63 (2024) 103864  \nContents lists available at ScienceDirect  \nTransfusion and Apheresis Science  \njournal [homepage:](homepage: www.elsevier.com/locate/transci)[ www.elsevier.com/locate/transci](homepage: www.elsevier.com/locate/transci)  \n| A study on diagnostic performance of different immunohematological diagnostic tests in assessing the prevalence of ABO Hemolytic Disease of Newborn in the antenatal O group mothers and their neonatal outcome in a tertiary care hospital in Northern India\u003Cbr>Joyisa Deba, Ashish Jain a, *, 1, Daljit Kaura, Anupama Bahadur b, Sriparna Basuc, Gita Negia\u003Cbr>a Department of Transfusion Medicine & Blood Bank, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India b Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India c Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand 249203, India |  |  | |\n| --- | --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords:\u003Cbr>Hemolytic Disease of Newborn (HDN) Conventional Tube Technique (CTT) Dithiothreitol (DTT)\u003Cbr>Direct Antiglobulin Test (DAT)\u003Cbr>Positive Predictive Value (PPV) Negative Predictive Value (NPV) |  | Background: Hemolytic disease of the newborn (HDN) results in the decreased lifespan of the red cells. HDN related to ABO incompatibility is mostly unnoticed because routine screening is not being done. This study was done to assess the prevalence of ABO-HDN and to compare different immunohematological tests. Methods-In this study 213 O group mothers and the 122 ABO-incompatible newborns born to them were included. Quantifying the maternal IgG anti-A/anti-B antibody titer was done by Conventional Tube Technique (CTT) using Dithiothreitol (DTT) pretreated maternal serum. Hemolysin test was performed on the mothers having titer > 256. These cases were followed up and, after delivery, were monitored for ABO HDN, along with direct antiglobulin testing and elution studies. The prevalence of ABO-HDN was calculated, and the different diagnostic parameters of the tests were calculated. Results-The prevalence of ABO-HDN in our population was estimated to be 1.7%, 6.1% & 10.6% in our population, O group mothers, and O group mothers with ABOincompatible newborns, respectively. Maternal titer≥ 512 strongly correlated with ABOHDN. DAT positivity is a good predictor of ABOHDN, especially using sensitive techniques. Maternal IgG titers have the highest sensitivity & Negative Predictive Value, while DAT has the highest specificity & Positive Predictive Value. Conclusion – Maternal ABO antibody titration may be advocated in the centers to identify high-risk groups. It can advocate institutional delivery and dedicated follow-up of newborns with ABO-HDN. Blood grouping & DAT may be performed in all newborns born to O blood group to identify high-risk cases. |  |\n\n1. Introduction  \nHemolytic disease of the newborn (HDN) is a condition that results in decreased lifespan of the red cells in newborns due to trans-placental transfer of IgG antibodies [1,2]. In clinical practices and literature, the important primary type of HDN described is Rh D HDN [3]. ABO-HDN is considered less severe because of the weak fetal expression of A/B antigens on fetal red cells, wider expression of ABO antigens not confined to red cells, and less hemolytic potential of the IgG2 subclass of antibodies [1]. However, in the recent past, the spectrum of HDN had a shifting paradigm due to the widespread practice of normal postpartum prophylactic Rh immunoglobulin to D-negative mothers. [3] ABO  \nincompatibility is now the most significant cause of HDN in the Western world [2]. ABO- HDN predominantly occurs in offsprings of O bloodgroup mothers because IgG Anti-A/B are more in the O group thanA or B groups. The clinical presentation is usually mild. Anemia is rare in ABO-HDN. A minor degree of red cell destruction ","cbCaianyUFIfSxO9","https://ap.wps.com/l/cbCaianyUFIfSxO9","pdf",1047846,"English","# Introduction\n# Materials and methods\n## Study design\n## Diagnostic tests and follow-up","[{\"question\":\"What condition does the study focus on?\",\"answer\":\"The study focuses on hemolytic disease of the newborn (HDN), specifically ABO-HDN, in O group mothers and their ABO-incompatible newborns.\"},{\"question\":\"How were maternal antibody levels measured in the study?\",\"answer\":\"Maternal IgG anti-A/anti-B antibody titers were quantified using the Conventional Tube Technique (CTT) with Dithiothreitol (DTT) pretreated maternal serum.\"},{\"question\":\"Which tests were compared for diagnostic performance?\",\"answer\":\"The study compares immunohematological tests including maternal IgG titers, Direct Antiglobulin Test (DAT), and hemolysin testing to assess diagnostic parameters and neonatal outcomes.\"}]","Transfusion and Apheresis Science 63 (2024) 103864 - Article | PDF",15]