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This narrative review summarizes evidence from English-language literature (2000–2025) evaluating EBV applications beyond emphysema, including persistent air leaks and bronchopleural fistulas, life-threatening haemoptysis, multidrug-resistant tuberculosis with collapse therapy, and critical care use for ventilatory weaning and lung isolation. Findings highlight clinically meaningful sealing of air leaks, limited complications, and potential improvements in TB outcomes, supporting the need for further research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/transforming-pulmonary-care-with-applications-of-endobronchial-valves-beyond-emphysema-a-narrative-review/441685/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/transforming-pulmonary-care-with-applications-of-endobronchial-valves-beyond-emphysema-a-narrative-review/441685.png","ImageObject",300,407,{"name":92,"@type":93},"Sarah ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What conditions beyond emphysema are endobronchial valves used for?","Question",{"text":112,"@type":113},"Endobronchial one-way valves have been used off-label for persistent air leaks/bronchopleural fistulas, life-threatening haemoptysis, multidrug-resistant tuberculosis with collapse therapy, and other complex pulmonary scenarios including critical care lung isolation.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What benefits are reported for valve placement in bronchopleural fistulas or air leaks?",{"text":117,"@type":113},"Case series report cessation or substantial reduction of air leaks in roughly half to 80% of patients, often enabling chest tube removal within days and avoiding reoperation.",{"name":119,"@type":110,"acceptedAnswer":120},"What kinds of complications have been reported with endobronchial valve use?",{"text":121,"@type":113},"Reported complications are uncommon and include valve migration, expectoration, transient hypoxaemia, and localized infection.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},441685,1790767433,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962085320529,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Review Article | Emerging Medical Technology Innovation and Translation   \nTransforming pulmonary care with applications of endobronchial valves beyond emphysema: a narrative review  \nMunir Adamu Bala^, Ra’fat Tawalbeh^, Vasileios Kouritas^  \nDepartment of Thoracic Surgery, Norfolk and Norwich University Hospital, Norwich, UK  \nContributions: (I) Conception and design: V Kouritas; (II) Administrative support: V Kouritas, R Tawalbeh; (III) Provision of study materials or patients: V Kouritas, M Adamu Bala; (IV) Collection and assembly of data: V Kouritas, M Adamu Bala; (V) Data analysis and interpretation: V Kouritas, M Adamu Bala; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \nCorrespondence to: Vasileios Kouritas, MD, CTh, MBA, CMgr, MCMI, PhD. Department of Thoracic Surgery, Norfolk and Norwich University  \nHospital, Colney Lane, Norwich NR4 7UY, [UK. Email: vasileios.kouritas@nnuh.nhs.uk](UK. Email: vasileios.kouritas@nnuh.nhs.uk).  \nBackground and Objective: Endobronchial one-way valves (EBVs) were originally developed for lung volume reduction in severe emphysema. Because EBVs allow unidirectional airflow, they have been used off‑label to manage persistent air leaks (PALs)/bronchopleural fistulas (BPFs), haemoptysis, cavitary tuberculosis (TB), and other complex pulmonary conditions. This review summarises the evidence of  \nendobronchial valve applications beyond emphysema.  \nMethods: We conducted a narrative review of English-language literature from January 1, 2000 to August  \n1, 2025, searching PubMed, Embase, Scopus, and Google Scholar for clinical trials, observational studies, case series, and case reports describing EBV use beyond emphysema. The selection of articles was based on relevance to the topic, with emphasis on clinical outcomes. No formal quantitative synthesis was performed  \ngiven the narrative scope.  \nKey Content and Findings: Across case series, EBV placement achieves cessation or substantial reduction of air leaks in roughly half to 80% of patients with postoperative or spontaneous BPFs, often allowing chest tube removal within days and avoiding reoperation. Reported complications are uncommon and include valve migration, expectoration, transient hypoxaemia, and localized infection. Case reports indicate EBVs can serve as emergency bronchoscopic plugs to control massive haemoptysis when conventional therapy fails. Emerging evidence in multidrug-resistant TB shows that collapse therapy using EBVs alongside appropriate chemotherapy accelerates sputum culture conversion and cavity closure; in a randomized trial, EBV treatment markedly improved culture conversion and long-term cure rates compared with chemotherapy alone. EBVs have also been used in critical care settings to isolate injured lungs and  \nfacilitate weaning from mechanical ventilation or extracorporeal membrane oxygenation (ECMO) .  \nConclusions: EBVs have evolved into a versatile tool in pulmonary medicine, extending well beyond emphysema treatment. The literature to date indicates that EBVs can effectively seal PALs, control focal pulmonary haemorrhage, and induce therapeutic lung collapse in cavitary disease—all with a minimally invasive approach. EBVs hold significant promise for improving patient care in challenging scenarios, and  \nfurther research is warranted.  \nKeywords: Endobronchial valves; bronchopleural fistula (BPF); haemoptysis; tuberculosis (TB); lung cancer  \nSubmitted Sep 08, 2025. Accepted for publication Nov 19, 2025. Published online Dec 23, 2025.  \ndoi: 10.21037/atm-25-138  \nView this article at: [https://dx.doi.org/10.21037/atm-25-138](https://dx.doi.org/10.21037/atm-25-138)  \n^ ORCID: Munir Adamu Bala, 0009-0008-2657-3364; Ra’fat Tawalbeh, 0000-0002-4075-2683; Vasileios Kouritas, 0000-0002-6046-7476.  \n© AME Publishing Company. Ann Transl Med 2025;13(6):77 | [https://dx.doi.org/10.21037/atm-25-138](https://dx.doi.org/10.21037/atm-25-138)  \nPage 2 of 18 Adamu Bala et al. Endob","cbCaisHVRxKYKFZG","https://ap.wps.com/l/cbCaisHVRxKYKFZG","pdf",294563,18,"English","# Background and Objective\n# Methods\n# Key Content and Findings\n# Conclusions\n# Introduction\n# Methods","[{\"question\":\"What conditions beyond emphysema are endobronchial valves used for?\",\"answer\":\"Endobronchial one-way valves have been used off-label for persistent air leaks/bronchopleural fistulas, life-threatening haemoptysis, multidrug-resistant tuberculosis with collapse therapy, and other complex pulmonary scenarios including critical care lung isolation.\"},{\"question\":\"What benefits are reported for valve placement in bronchopleural fistulas or air leaks?\",\"answer\":\"Case series report cessation or substantial reduction of air leaks in roughly half to 80% of patients, often enabling chest tube removal within days and avoiding reoperation.\"},{\"question\":\"What kinds of complications have been reported with endobronchial valve use?\",\"answer\":\"Reported complications are uncommon and include valve migration, expectoration, transient hypoxaemia, and localized infection.\"}]","Transforming pulmonary care with applications of endobronchial valves beyond emphysema - a narrative review | PDF",1790697078,45]