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An exploratory study compared survival-relevant gene expression between Black (n=8) and White (n=20) patients using transcriptomic sequencing of over 24,900 genes across pancreatic tumor and non-tumor tissues. Differential expression was observed in thousands of genes, including 1,200 race-comparison genes. TSPAN8 emerged as a potential tumor-specific overexpressed gene in Black patients, and pathway analysis highlighted over 40 affected canonical pathways. Elevated TSPAN8 associated with poor overall survival, supporting larger genomic studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/transcriptomic-analysis-of-pancreatic-adenocarcinoma-specimens-obtained-from-black-and-white-patients/383305/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/transcriptomic-analysis-of-pancreatic-adenocarcinoma-specimens-obtained-from-black-and-white-patients/383305.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-28","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What clinical disparity motivated this study?","Question",{"text":112,"@type":113},"The study addresses that Black patients are under-represented in pancreatic cancer clinical trials and have higher morbidity and mortality compared with other racial groups.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the transcriptomic data generated and compared?",{"text":117,"@type":113},"Transcriptomic sequencing of over 24,900 genes was performed on pancreatic tumor and non-tumor tissues from Black and White patients, followed by differential expression analyses across race and tissue comparisons.",{"name":119,"@type":110,"acceptedAnswer":120},"Which gene was identified as potentially important for Black patients?",{"text":121,"@type":113},"TSPAN8 was identified as a potential tumor-specific gene significantly overexpressed in pancreatic tumor tissue from Black patients versus White patients, and higher expression was linked to poor overall survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383305,1790554639,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","PLOS ONE  \nOPEN ACCESS  \nCitation: Biel TG, Petrovskaya S, Mascia F, Ju T, Fashoyin-Aje L, Herremans KM, et al. (2023) Transcriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients. PLoS ONE 18(2): e0281182 .  \n[https://doi.org/10.1371/journal.pone.0281182](https://doi.org/10.1371/journal.pone.0281182)  \n[Editor:](Editor: Kenji Fujiwara)[ Kenji Fujiwara](Editor: Kenji Fujiwara), [Kyushu University](Kyushu University) Hospital: Kyushu Daigaku Byoin, JAPAN  \nReceived: October 12, 2022  \nAccepted: January 17, 2023  \nPublished: February 22, 2023  \nCopyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.  \nData Availability Statement: All relevant data are within the paper and its Supporting Information files. The raw data is also openly available in NCBI’s Gene Expression Omnibus ([https://www.ncbi.nlm](https://www.ncbi.nlm). [nih.gov/geo/query/acc.cgi?acc=GSE211398](nih.gov/geo/query/acc.cgi?acc=GSE211398)) with accession number GSE211398 .  \nFunding: This projected was supported by the Office of Biotechnology Products and the Oncology Center for Excellence at the United States Food and Drug Administration. Authors were also supported by the National Human Genome Research Institute  \nRESEARCH ARTICLE  \nTranscriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients  \nThomas G. Biel1, Svetlana Petrovskaya1, Francesca Mascia1, Tongzhong Ju1,  \nLola Fashoyin-Aje2, Kelly M. Herremans3, Andrea N. Riner3, Patrick W. Underwood3, Michael H. Gerber3¤a, Martha Donoghue2, Jose G. Trevino3¤b, V. Ashutosh Rao1 *  \n1 Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America, 2 Office of Oncologic Diseases, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America, 3 Department of Surgery, College of Medicine, University of Florida, Gainesville, Florida, United States of America  \n¤a Current address: Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona, United States of America  \n¤b Current address: Division of Surgical Oncology, Massy Cancer Center, Virginia Commonwealth University, Richmond, Virginia, United States of America  \n* [Ashutosh.Rao@fda.hhs.gov](Ashutosh.Rao@fda.hhs.gov)  \nAbstract  \nIn pancreatic cancer clinical trials, Black patients are under-represented while having higher morbidity and mortality rates as compared to other racial groups. Multiple factors, including socioeconomic and lifestyle factors may contribute to this disparity, but genomic contributions remain unclear. In an exploratory project to identify genes that may contribute to differences in survival between Black (n = 8) and White (n = 20) patients with pancreatic cancer, transcriptomic sequencing of over 24,900 genes was performed in human pancreatic tumor and non-tumor tissue obtained from Black and White patients. Over 4,400 genes were differentially expressed in tumor and non-tumor tissue, irrespective of race. To validate these results, the expression of four genes (AGR2, POSTN, TFF1, and CP) reported to be up-regulated in pancreatic tumor tissue as compared to non-tumor tissue were confirmed using quantitative PCR. Transcriptomic analysis that compared pancreatic tumor tissue from Black and White patients revealed differential expression in 1,200 genes, while a comparison of the non-tumor and tumor gene expression differences within each race revealed over 1,500 tumor-specific differentially expressed genes in pancreatic tumor and non-tumor tissue from Black patients. We identified TSPAN8 as a potential tumor-specific gene significantly overexpressed in p","cbCaigQsATQ2gFRm","https://ap.wps.com/l/cbCaigQsATQ2gFRm","pdf",2326078,18,"English","# Abstract\n## Introduction","[{\"question\":\"What clinical disparity motivated this study?\",\"answer\":\"The study addresses that Black patients are under-represented in pancreatic cancer clinical trials and have higher morbidity and mortality compared with other racial groups.\"},{\"question\":\"How was the transcriptomic data generated and compared?\",\"answer\":\"Transcriptomic sequencing of over 24,900 genes was performed on pancreatic tumor and non-tumor tissues from Black and White patients, followed by differential expression analyses across race and tissue comparisons.\"},{\"question\":\"Which gene was identified as potentially important for Black patients?\",\"answer\":\"TSPAN8 was identified as a potential tumor-specific gene significantly overexpressed in pancreatic tumor tissue from Black patients versus White patients, and higher expression was linked to poor overall survival.\"}]","Transcriptomic analysis of pancreatic adenocarcinoma specimens obtained from Black and White patients | PDF",1790255803,45]