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Univariate and multivariate regression and matched survival analyses were used to define predictive risks and inform TACE implementation in resource-limited 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Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2025 December 14; 31(46): 112249  \nDOI: 10.3748/wjg.v31.i46.112249 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \nORIGINAL ARTICLE  \nRetrospective Cohort Study  \nTransarterial chemoembolization outcomes for advanced hepatocellular carcinoma vs sorafenib and best supportive care in a sub-Saharan African cohort  \nSanju Sobnach, Karla Christina Sousa Silva, Ebtesam Abdel-Rashid Abdel-Shafy, Muhammad Emmamally, Catherine Wendy Spearman, Marc Bernon, Mark W Sonderup, Keith Venter, Inae Kim, Urda Kotze, Rajshree Segobin, Dale K Creamer, Stefano Cacciatore, Luiz Fernando Zerbini, Eduard Jonas  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade A, Grade B, Grade B, Grade B Novelty: Grade A, Grade A, Grade B, Grade B, Grade B  \nCreativity or Innovation: Grade A, Grade B, Grade B, Grade B, Grade B  \nScientific Significance: Grade A, Grade A, Grade B, Grade B, Grade B  \nP-Reviewer: Balbaa M, PhD, Professor, Egypt; Giangregorio F, Assistant Professor, Chief Physician, Director, Italy; Ke Y, MD, PhD, Associate Professor, China  \nReceived: July 23, 2025  \nRevised: September 9, 2025  \nAccepted: October 31, 2025  \nPublished online: December 14, 2025  \nSanju Sobnach, Muhammad Emmamally, Marc Bernon, Keith Venter, Inae Kim, Urda Kotze, Eduard Jonas, Department of Surgery, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Western Cape, South Africa  \nKarla Christina Sousa Silva, Luiz Fernando Zerbini, Cancer Genomics Group, International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, Western Cape, South Africa  \nEbtesam Abdel-Rashid Abdel-Shafy, Stefano Cacciatore, Bioinformatics Unit, International Centre for Genetic Engineering and Biotechnology, Cape Town 7925, Western Cape, South Africa  \nCatherine Wendy Spearman, Mark W Sonderup, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, Western Cape, South Africa  \nRajshree Segobin, Dale K Creamer, Division of Radiology, University of Cape Town, Cape Town 7925, Western Cape, South Africa  \nCo-first authors: Sanju Sobnach and Karla Christina Sousa Silva.  \nCo-corresponding authors: Luiz Fernando Zerbini and Eduard Jonas.  \nCorresponding author: Luiz Fernando Zerbini, Director, Cancer Genomics Group, International Centre for Genetic Engineering and Biotechnology, Anzio Road, Observatory, Cape Town 7925, Western Cape, [South Africa.](South Africa. luiz.zerbini@icgeb.org)[ luiz.zerbini@icgeb.org](South Africa. luiz.zerbini@icgeb.org)  \nAbstract  \nBACKGROUND  \nSub-Saharan Africa (SSA) and Southeast Asia account for 80% of hepatocellular carcinoma (HCC) cases globally. Public healthcare systems in low-and middleincome countries often face significant economic constraints, resulting in limited treatment options. The objectives of this study were to identify factors associated with poor outcomes in patients with Barcelona Clinic Liver Cancer (BCLC) stage C and D undergoing transarterial chemoembolization (TACE) and to compare  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 14, 2025  Volume 31  Issue 46   \nSobnach S et al. TACE outcome predictors in SSA  \nProcessing time: 140 Days and 20.2 Hours  \ntheir outcomes to patients treated tyrosine kinase inhibitors (TKIs) or best supportive care (BSC) only.  \nAIM  \nTo assess clinical outcomes and identify predictive factors that may facilitate the broader implementation of TACE in patients with advanced HCC within resource-constrained settings such as SSA.  \nMETHODS  \nA single-center, retrospective cohort study was conducted to investigate the risk factors associated with the outcome of TACE in patient","cbCaiemgGZasqMth","https://ap.wps.com/l/cbCaiemgGZasqMth","pdf",2975383,16,"English","# Background\n# Aim\n# Methods\n# Results\n# Conclusion\n# Key Words","[{\"question\":\"Which clinical factors were associated with poor TACE response in advanced HCC patients?\",\"answer\":\"Elevated gamma-glutamyl transferase, elevated aspartate aminotransferase, and portal vein infiltration were identified as high-risk features linked to poor TACE response.\"},{\"question\":\"How did overall survival differ between patients treated with TACE versus TKIs or best supportive care?\",\"answer\":\"Patients with BCLC stage C who lacked high-risk features had significantly longer overall survival with TACE compared with those receiving best supportive care or TKIs.\"},{\"question\":\"What was the study design and how were treatment groups compared?\",\"answer\":\"A single-center retrospective cohort study used univariate and multivariate regression, frequency matching for confounders across TACE, TKIs, and best supportive care groups, and survival analysis to compare matched outcomes.\"}]","Transarterial Chemoembolization Outcomes for Advanced Hepatocellular Carcinoma vs Sorafenib and Best Supportive Care in a Sub-Saharan African Cohort - Original Article - Retrospective Cohort Study | PDF",1790564963]