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Participants received one 75 mg oral capsule and/or topical 1 g cream containing 1.5% trans-resveratrol twice daily for 8 weeks. Outcomes included wrinkle scoring, skin age, temperature, pore size, pigmentation, sebum, moisture, elasticity, self-reports, serum concentrations, and safety. At week 8, wrinkle scores decreased in the oral-and-topical group, while topical dosing increased sebum; other parameters showed no significant changes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/trans-resveratrol-reduces-visible-signs-of-skin-ageing-in-healthy-adult-females-over-40-an-8-week-randomized-placebo-controlled-trial/416180/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/trans-resveratrol-reduces-visible-signs-of-skin-ageing-in-healthy-adult-females-over-40-an-8-week-randomized-placebo-controlled-trial/416180.png","ImageObject",300,407,{"name":92,"@type":93},"Stanley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What study design was used to evaluate trans-resveratrol on skin ageing?","Question",{"text":112,"@type":113},"The trial used a double-blind, randomized, placebo-controlled design.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was trans-resveratrol administered and for how long?",{"text":117,"@type":113},"Participants received a 75 mg oral capsule and/or a topical 1 g cream with 1.5% trans-resveratrol twice daily for 8 weeks.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding wrinkles and sebum?",{"text":121,"@type":113},"Wrinkle scores were significantly reduced at week 8 in the oral-and-topical group versus the placebo group, and topical active treatment increased sebum levels at week 8.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},416180,1790648371,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},2336477405376,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","TYPE Clinical Trial  \nPUBLISHED 19 December 2025 DOI 10.3389/fragi.2025.1727244  \nOPEN ACCESS  \nEDITED BY  \nXinyu Wang,  \nPhiladelphia College of Osteopathic Medicine (PCOM), United States  \nREVIEWED BY  \nGautham Yepuri,  \nNew York University, United States Debashish Das,  \nNarayana Nethralaya Eye Hospital, India  \n*CORRESPONDENCE  \nThomas A. Tompkins,  \n [ttompkins@lallemand.com](ttompkins@lallemand.com)  \nRECEIVED 17 October 2025  \nREVISED 04 December 2025  \nACCEPTED 08 December 2025  \nPUBLISHED 19 December 2025  \nCITATION  \nRao A, Briskey D, Roche G, Tremblay A, Da Silva Pinto M and Tompkins TA (2025) Transresveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial.  \nFront. Aging 6:1727244 .  \ndoi: 10.3389/fragi.2025.1727244  \nCOPYRIGHT  \n© 2025 Rao, Briskey, Roche, Tremblay, Da Silva Pinto and Tompkins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nTrans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40: an 8-week randomized placebo-controlled trial  \nAmanda Rao 1,2, David Briskey 1,2, Georgia Roche 1, Annie Tremblay3, Marcia Da Silva Pinto 3,4 and Thomas A. Tompkins 3*  \n1RDC Clinical, Brisbane, QLD, Australia, 2School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, QLD, Australia, 3Lallemand Bio-Ingredients, Montreal, QC, Canada, 4Evolva AG, Reinach, Switzerland  \nIntroduction: This double-blind, randomised, placebo-controlled clinical study evaluated the effects of trans-resveratrol on skin health. To date, and to the best of our knowledge, no study has tested trans-resveratrol as the only active ingredient, orally or topically, for improving skin parameters in humans. Therefore, the aim of this study was to investigate the effects of transresveratrol on skin health and visible signs of ageing, when administered orally and/or applied topically to the face.  \nMethods: Healthy females aged 40 years and older were randomly assigned to one of four groups: placebo oral and topical (P/P Group), trans-resveratrol oral and placebo topical (A/P Group), placebo oral and trans-resveratrol topical (P/A Group), and trans-resveratrol oral and topical (A/A Group) . Participants were instructed to take one capsule (75 mg trans-resveratrol) and apply 1 g of cream (1 .5% trans-resveratrol) twice daily for 8 weeks. Outcome measures included wrinkle assessment, skin age, temperature, pore size, forehead lines, glabellar lines, Crow’s feet, nasolabial folds, pigmentation, sebum levels, moisture, and elasticity, along with a self-assessment questionnaire, serum trans-resveratrol concentrations, and safety.  \nResults: Out of 134 participants enrolled, 122 completed the study. Results indicated significantly reduced wrinkle scores in the A/A Group compared to the P/P Group at week 8. All treatment groups showed increased sebum levels, with the active topical groups (P/A and A/A Groups) having significantly higher U-zone sebum at week 8 compared to placebo topical groups (P/P and A/P Groups) . No significant differences were found in other skin parameters. Serum trans-resveratrol conjugate levels increased significantly in the A/P and A/A Groups at week 4 and 8. All trial products were shown to be safe with minimal and only mild adverse events recorded in every group.  \nConclusion: Oral and topical trans-resveratrol treatment can help improve skin health parameters. When taken orally and applied topically, trans-resveratrol was effective at wrinkle reduction, and when applied topically, it increased sebum levels. Cli","cbCaigUu0HyQ1SeJ","https://ap.wps.com/l/cbCaigUu0HyQ1SeJ","pdf",3436567,12,"English","# Introduction\n# Methods\n# Results\n# Conclusion","[{\"question\":\"What study design was used to evaluate trans-resveratrol on skin ageing?\",\"answer\":\"The trial used a double-blind, randomized, placebo-controlled design.\"},{\"question\":\"How was trans-resveratrol administered and for how long?\",\"answer\":\"Participants received a 75 mg oral capsule and/or a topical 1 g cream with 1.5% trans-resveratrol twice daily for 8 weeks.\"},{\"question\":\"What were the main findings regarding wrinkles and sebum?\",\"answer\":\"Wrinkle scores were significantly reduced at week 8 in the oral-and-topical group versus the placebo group, and topical active treatment increased sebum levels at week 8.\"}]","Trans-resveratrol reduces visible signs of skin ageing in healthy adult females over 40 - an 8-week randomized placebo-controlled trial | PDF",1790604435]