[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-340432-105":59,"doc-detail-340432-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","traditional-chinese-medicine-in-treating-upper-digestive-tract-cancers","Traditional Chinese medicine in treating upper digestive tract cancers","","Upper digestive tract cancers, including oral cavity, laryngeal, esophageal, and gastric cancers, represent a substantial global cancer burden with limited effectiveness of conventional therapies and frequent adverse effects and drug resistance. Chinese herbal drugs (CHDs) are widely used in East Asia. This narrative review summarizes 138 CHDs reported in clinical studies up to June 2024, highlighting improvements in efficacy and/or reduction of adverse effects. Four CHDs increased five-year survival rates, while Zengshengping shows convincing evidence for preventing esophageal cancer. Limitations include small non-multicenter trials and limited mechanistic and component investigations, with a need for standardized, rigorously designed studies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/traditional-chinese-medicine-in-treating-upper-digestive-tract-cancers/340432/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/traditional-chinese-medicine-in-treating-upper-digestive-tract-cancers/340432.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which upper digestive tract cancers are covered in the review?","Question",{"text":112,"@type":113},"The review focuses on cancers of the oral cavity, laryngeal region, esophagus, and stomach, along with broader upper digestive tract cancers in the introduction.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many Chinese herbal drugs (CHDs) were summarized for upper digestive tract cancer treatment?",{"text":117,"@type":113},"The review summarizes 138 CHDs in total, with 126 CHDs tested for cancer treatment, typically in combination with conventional therapies.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence is highlighted for preventing esophageal cancer?",{"text":121,"@type":113},"Zengshengping is described as the only CHD proven to prevent the development of esophageal cancer with convincing evidence.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},340432,1790163760,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Huang et al. Molecular Cancer (2024) 23:250 [https://doi.org/10.1186/s12943-024-02149-x](https://doi.org/10.1186/s12943-024-02149-x)  \nMolecular Cancer  \n REVIEW Open Access  \nTraditional Chinese medicine in treating upper digestive tract cancers  \nAlexis Shiying Huang1,2†, Jiaying Wu1,2†, Aftab AMIN3, Xiu-Qiong Fu 1,2* and Zhi-Ling Yu1,2,4*  \nAbstract  \nUpper digestive tract cancers, such as oral cavity, laryngeal, esophageal, and gastric cancers, account for 10% of cancer cases and 14. 5% of cancer-related deaths worldwide. Conventional treatments often provide limited survival benefits and are frequently associated with adverse effects and drug resistance. Chinese herbal drugs (CHDs) are widely used in the Far East for managing these cancers. In this narrative review, we summarize current clinical studies (published up to June 2024) on the use of 138 CHDs in the treatment of cancers and precancerous lesions of the upper digestive tract. For cancer treatment, 126 CHDs were tested, all in combination with conventional therapies. Each CHD increased the clinical efficacy and/or reduced the adverse effects of conventional therapies. The five-year survival rate is a critical metric for evaluating the clinical benefits of cancer treatments. Four of the CHDs were reported to increase five-year survival rates of patients receiving conventional therapies. The four CHDs are Sishen Jiedu Decoction, Pingxiao Tablet, Fuzheng Guben Granule, and Buyang Huanwu Tang. For managing precancerous lesions, 12 CHDs were tested: six used alone and six in combination with conventional therapies. Zengshengping is one of the CHDs used alone and is the only one that has been proven to prevent the development of esophageal cancer with convincing evidence. This review provides information about the clinical benefits of CHDs and offers a reference for their rational application in treating upper digestive tract cancers. The reviewed studies have limitations: most trials had small sample sizes and were not multi-center; only one study investigated the mechanisms of action of the studied CHD; and the active components of CHDs were not explored. To promote international recognition of CHDs, rigorously designed studies on clinical outcomes, mechanisms of action, and active components are warranted. Moreover, the studied CHDs should be standardized.  \n†Alexis Shiying Huang and Jiaying Wu contributed equally to this work.  \n*Correspondence: Xiu-Qiong Fu [makyfu@hkbu.edu.hk](makyfu@hkbu.edu.hk)[ ](makyfu@hkbu.edu.hk)Zhi-Ling Yu [zlyu@hkbu.edu.hk](zlyu@hkbu.edu.hk)  \n1 Consun Chinese Medicines Research Centre for Renal Diseases, Hong Kong Baptist University, Hong Kong, China  \n2 Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China  \n3 Division of Life Science, Center for Cancer Research, and State Key Lab of Molecular Neuroscience, Hong Kong University of Science and Technology, Hong Kong, China  \n4 Research and Development Centre for Natural Health Products, HKBU Institute for Research and Continuing Education, Shenzhen, China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,","cbCaitlWW6X1XMZu","https://ap.wps.com/l/cbCaitlWW6X1XMZu","pdf",1822673,62,"English","# Abstract\n# Introduction\n# Methods\n## Data sources and search methods","[{\"question\":\"Which upper digestive tract cancers are covered in the review?\",\"answer\":\"The review focuses on cancers of the oral cavity, laryngeal region, esophagus, and stomach, along with broader upper digestive tract cancers in the introduction.\"},{\"question\":\"How many Chinese herbal drugs (CHDs) were summarized for upper digestive tract cancer treatment?\",\"answer\":\"The review summarizes 138 CHDs in total, with 126 CHDs tested for cancer treatment, typically in combination with conventional therapies.\"},{\"question\":\"What evidence is highlighted for preventing esophageal cancer?\",\"answer\":\"Zengshengping is described as the only CHD proven to prevent the development of esophageal cancer with convincing evidence.\"}]","Traditional Chinese medicine in treating upper digestive tract cancers | PDF",1790036459,156]