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This nationwide retrospective cohort study assessed epidemiological characteristics, coagulation factor consumption, hospital length of stay, complications, and primary TKR failure in Taiwan. A cohort of 996 hemophilia patients (1995–2011) included 103 primary TKRs (75 patients) with mean follow-up of 77.9 months.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/total-knee-replacement-for-patients-with-severe-hemophilic-arthropathy-in-taiwan-a-nationwide-population-based-retrospective-study/436892/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/total-knee-replacement-for-patients-with-severe-hemophilic-arthropathy-in-taiwan-a-nationwide-population-based-retrospective-study/436892.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of the nationwide study on severe hemophilia patients in Taiwan?","Question",{"text":112,"@type":113},"To investigate major epidemiological characteristics, coagulation factor consumption, length of hospital stay, complications, and the failure rate of primary TKR in severe hemophilia patients in Taiwan.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many patients and primary TKRs were included, and what was the follow-up duration?",{"text":117,"@type":113},"The cohort included 996 hemophilia patients registered between 1995 and 2011, with 103 primary TKRs performed on 75 patients; mean follow-up duration was 77.9 months.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main outcome findings for prosthesis failure and survivorship?",{"text":121,"@type":113},"Failure occurred in 8 patients (8.5%) with mean time to failure of 32.8 months, and the 10-year prosthesis survivorship was 88.6%.",{"name":123,"@type":110,"acceptedAnswer":124},"How did simultaneous bilateral TKR compare with staged bilateral TKR in cost-effectiveness?",{"text":125,"@type":113},"Simultaneous procedures significantly reduced mean total cost compared with staged-bilateral TKRs (USD 61,587 vs USD 101,923), making bilateral simultaneous TKR more preferable for cost-effectiveness.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},436892,1791250218,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","J Chin MedAssoc  \nOriginal article  \nTotal knee replacement for patients with severe hemophilic arthropathy in Taiwan: A nationwide population-based retrospective study  \nCheng-Fong Chena,b,c,*, Yuan-Bin Yuc,d, Shang-Wen Tsaia,b,c, Jan-Wei Chiuc,e, Liang-Tsai Hsiaoc,d, Jyh-Pyng Gauc,d, Hui-Chi Hsuc,d  \naDivision of Joint Reconstruction, Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; bDepartment of Surgery, School of Medicine, National Yang Ming Chiao Tong University, Taipei, Taiwan, ROC; cHaemophilia and Thrombosis Comprehensive Treatment Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; dDivision of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; eDepartment of Physical Medicine and Rehabilitation, Taipei Veterans General Hospital, Taipei, Taiwan, ROC  \nAbstract  \nBackground: Total knee replacement (TKR) surgery is a treatment option for advanced hemophilic arthropathy. Due to its rarity and complexity, previous reports could only demonstrate the results of single-site studies including few cases. This populationbased study aimed to investigate the major epidemiological characteristics, mean consumption of coagulation factors, length of hospital stays, complications, and failure rate of primary TKR for severe hemophilia patients in Taiwan.  \nMethods: A cohort of 996 hemophilia patients registered between 1995 and 2011 was included, and 103 primary TKRs were performed on 75 patients. Unilateral TKR was performed on 47 patients and bilateral TKRs on the remaining 28 patients, including 12 simultaneous and 16 staged surgeries. The mean age at surgery was 32.3 years (range, 17.3–55.7), and the mean follow-up duration was 77.9 months (range, 2.3–176.8) .  \nResults: Failure was noted in 8 patients (8 .5%) at mean 32.8 months (range, 2.3–95) after surgery. Four patients revealed aseptic loosening, whereas infection in 4. The 10-year prosthesis survivorship was 88.6% . For patients receiving unilateral TKR, the mean length of hospital stay was 15 days (range, 7–32) . The mean cost of factor supplement was United States Dollar (USD) 43543 with a mean 4-unit packed red blood cells transfusion (range, 0–38) . The total admission cost was USD 48326 (range, USD 4165–262 619) . Conclusion: The prevalence of TKA for hemophilia patients was 7.5% in Taiwan. The mean hospital stay was 14 days, and the 10-year prosthesis survivorship was 88.6% . The mean daily factor usage was decreased from 235.7 units preoperatively to 202.1 units postoperatively. In comparison with the staged-bilateral TKRs, the simultaneous procedures significantly reduced the mean total cost from USD 101923 to USD 61587 (p = 0.023) . Therefore, in terms of cost-effectiveness, bilateral simultaneous TKR is more preferable than staged procedures.  \nKeywords: Arthroplasty, Replacement, Knee; Epidemiology; Hemophilia A; Taiwan  \n1. INTRODUCTION  \nThe knee is the most commonly involved joint tissue in hemophilia patients.1–4 Recurrent hemoarthrosis may result in chronic synovitis and advanced hemophilic arthropathy at the end stage of the disease. The symptoms include severe pain, limited range of motion (ROM), and impaired knee function.  \n*Address correspondence. Dr. Cheng-Fong Chen, Department of Orthopedicsand Traumatology, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail address: cf_chen@vghtpe.gov.tw](ROC. E-mail address: cf_chen@vghtpe.gov.tw) (C.-F. Chen). Conflicts of interest: Dr. Hui-Chi Hsu, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article. The other authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2022) 85: 228-232.  \nReceived July 4, 2021; accepted August 25, 2021.  \ndoi: 10. 109","cbCaijNyCRfOcHPr","https://ap.wps.com/l/cbCaijNyCRfOcHPr","pdf",531993,"English","# Introduction\n# Methods\n## Study population and cohort\n# Results\n# Conclusion","[{\"question\":\"What was the purpose of the nationwide study on severe hemophilia patients in Taiwan?\",\"answer\":\"To investigate major epidemiological characteristics, coagulation factor consumption, length of hospital stay, complications, and the failure rate of primary TKR in severe hemophilia patients in Taiwan.\"},{\"question\":\"How many patients and primary TKRs were included, and what was the follow-up duration?\",\"answer\":\"The cohort included 996 hemophilia patients registered between 1995 and 2011, with 103 primary TKRs performed on 75 patients; mean follow-up duration was 77.9 months.\"},{\"question\":\"What were the main outcome findings for prosthesis failure and survivorship?\",\"answer\":\"Failure occurred in 8 patients (8.5%) with mean time to failure of 32.8 months, and the 10-year prosthesis survivorship was 88.6%.\"},{\"question\":\"How did simultaneous bilateral TKR compare with staged bilateral TKR in cost-effectiveness?\",\"answer\":\"Simultaneous procedures significantly reduced mean total cost compared with staged-bilateral TKRs (USD 61,587 vs USD 101,923), making bilateral simultaneous TKR more preferable for cost-effectiveness.\"}]","Total knee replacement for patients with severe hemophilic arthropathy in Taiwan: A nationwide population-based retrospective study | PDF",1790679362,13]