[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-160000-en":3,"doc-seo-160000-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},160000,962075114101,"Seraphina","https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165",7,"Healthcare","TOPICAL DELIVERY OF QUERCETIN LOADED TRANSFERSOMES FOR WOUND TREATMENT - IN VITRO AND IN VIVO EVALUATION","Design and evaluation of topical quercetin (Qc)-loaded transfersomes (TFs) for wound healing were conducted through thin-film hydration preparation and factorial optimization to select an optimum formulation. In vitro and in vivo experiments assessed skin deposition and cutaneous wound induction in four male Wistar rat groups, followed by biochemical profiling of total proteins, antioxidant capacity, glutathione reductase, nitric oxide, and malonaldehyde. Histopathology was performed to compare healing efficacy versus liposomes and Qc suspension and to confirm formulation safety.","International Journal of Applied Pharmaceutics  \nISSN-0975-7058 Vol 13, Issue 5, 2021  \nOriginal Article  \nTOPICAL DELIVERY OF QUERCETIN LOADED TRANSFERSOMES FOR WOUND TREATMENT: IN VITRO  \nAND IN VIVO EVALUATION  \nMARWA ABDALLAH1*, DEMIANA I. NESSEEM1, OMAIMA N. ELGAZAYERLY2, ALYA. ABDELBARY2,3  \n1National Organization of Drug Control and Research, Pharmaceutics Department, Egypt, 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt, 3School of Life and Medical Sciences, University of Hertfordshire hosted by  \nGlobal Academic Foundation, Cairo, Egypt  \n[Email: dr_maramiro@msn.com](Email: dr_maramiro@msn.com)  \nReceived: 14 Mar 2021, Revised and Accepted: 13 Jul 2021  \nABSTRACT  \nObjective: To design topical Quercetin (Qc)-loaded transfersomes (TFs) for wound treatment.  \nMethods: Qc-loaded TFs were prepared by thin-film hydration technique using 2241full factorial design and the optimum formula was selected. In vivo skin, deposition and cutaneous wound induction studies were performed for four groups of male wistar rats. At the end of the experiment, biochemical parameters were measured in the healed tissues (total proteins (TP), total antioxidant capacity (TAC), glutathione reductase (GSH), nitric oxide (NO), and malonaldehyde (MDA). Two in vivo histopathological experiments using male wistar rats were performed; the first study was done for the healed tissues ofthe above experiment and the second was to confirm the safety of formulations.  \nResults: Qc optimum TFs (F6) showed EE% of 91.1%, PS of 695.35 nm, PDI of 0.592, and ZP of-11.1 mV, and spherical shape. In vivo skin deposition study showed that drug percentage retained in the skin from Qc optimum TFs was significantly higher than that from Qc suspension and Qc liposomes (p\u003C0.05) . There was no significant difference in the values of TP, TAC and MDA between the treated groups (p>0.05) . GSH in TFs treated groups was significantly higher than the other groups (p\u003C0.05) while NO in TFs treated groups was significantly lower than the other treated groups (p\u003C0.05). Histopathological experiments showed that wounds treated by TFs healed better than those treated by both liposomes and Qc suspension.  \nConclusion: Qc-loaded TFs can be used as successful drug-delivery system for wound healing.  \nKeywords: Quercetin, Transfersomes, Wound treatment, Topical formulation  \n© 2021 The Authors. Published by Innovare Academic Sciences Pvt Ltd. This is an open access article under the CC BY license ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)) DOI: [https://dx.doi.org/10.22159/ijap.2021v13i5.41435. Journal homepage:](https://dx.doi.org/10.22159/ijap.2021v13i5.41435. Journal homepage:) [https://innovareacademics.in/journals/index.php/ijap](https://innovareacademics.in/journals/index.php/ijap)  \nINTRODUCTION  \nHerbal drugs have been used in many diseases [1] . Plant pigments which are found in herbal drugs as flavonoids which are also found in fruits and vegetables, have many physiological activities [2] . Flavonoids are important drug candidates due to their free radical scavenging and anti-inflammatory properties [3, 4] . There is a structure-activity relationship between several flavonoids (luteolin, kaempferol, and chrysin) and their antioxidant activity and the number of OH groups in their structure so they are used in inflammatory disorders such as psoriasis and arthritis [5] .  \nQuercetin (Qc) has high antioxidant activity which reduces the expression of matrix metalloproteinase that causes wrinkling and decreasing of the elasticity of healthy and photoaged skin [6] . Qc has antioxidant and antiradical effects due to three functional groups in its structure [7-9] . Nanotechnology is urgently needed for herbal drugs due to the poor solubility of those drugs [10] . The topical application of Qc in various formulation approaches includes permeation enhancers [11] such as lecithin and ","cbCaiuLObDuqBKmm","https://ap.wps.com/l/cbCaiuLObDuqBKmm","pdf",887610,1,9,"English","en",105,"# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Rationale for flavonoids and quercetin\n## Role of topical delivery and transfersomes\n# Materials and Methods\n## Materials","[{\"question\":\"What was the objective of the study on quercetin-loaded transfersomes?\",\"answer\":\"To design topical quercetin (Qc)-loaded transfersomes for wound treatment and evaluate their performance.\"},{\"question\":\"How were the quercetin-loaded transfersomes prepared and optimized?\",\"answer\":\"They were prepared by thin-film hydration using a 2^4 full factorial design, and the optimum formulation was selected.\"},{\"question\":\"What were the key findings from in vivo skin deposition and biochemical evaluations?\",\"answer\":\"The optimum Qc TFs showed significantly higher drug retention in skin versus Qc suspension and Qc liposomes. Glutathione was higher and nitric oxide was lower in TF-treated groups, while total proteins, total antioxidant capacity, and malonaldehyde showed no significant differences among treated groups.\"}]","TOPICAL DELIVERY OF QUERCETIN LOADED TRANSFERSOMES FOR WOUND TREATMENT - IN VITRO AND IN VIVO EVALUATION | PDF",1788042761,23,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"topical-delivery-of-quercetin-loaded-transfersomes-for-wound-treatment-in-vitro-and-in-vivo-evaluation","",{"@graph":36,"@context":85},[37,54,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/healthcare/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/topical-delivery-of-quercetin-loaded-transfersomes-for-wound-treatment-in-vitro-and-in-vivo-evaluation/160000/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":62,"encodingFormat":61,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-29",true,{"@type":65,"interactionType":66,"userInteractionCount":4},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"What was the objective of the study on quercetin-loaded transfersomes?","Question",{"text":75,"@type":76},"To design topical quercetin (Qc)-loaded transfersomes for wound treatment and evaluate their performance.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"How were the quercetin-loaded transfersomes prepared and optimized?",{"text":80,"@type":76},"They were prepared by thin-film hydration using a 2^4 full factorial design, and the optimum formulation was selected.",{"name":82,"@type":73,"acceptedAnswer":83},"What were the key findings from in vivo skin deposition and biochemical evaluations?",{"text":84,"@type":76},"The optimum Qc TFs showed significantly higher drug retention in skin versus Qc suspension and Qc liposomes. Glutathione was higher and nitric oxide was lower in TF-treated groups, while total proteins, total antioxidant capacity, and malonaldehyde showed no significant differences among treated groups.","https://schema.org",{"og:url":52,"og:type":87,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":89,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":92},[93,97,101,105,110,115,118,123,127,130,134],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":46,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":46,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":116,"slug":117},40,"healthcare",{"id":119,"doc_module":4,"doc_module_name":46,"category_name":120,"show_sort_weight":121,"slug":122},8,"Research & Report",30,"research-report",{"id":21,"doc_module":4,"doc_module_name":46,"category_name":124,"show_sort_weight":125,"slug":126},"Religion & Spirituality",20,"religion-spirituality",{"id":125,"doc_module":4,"doc_module_name":46,"category_name":128,"show_sort_weight":125,"slug":129},"World Cup","world-cup",{"id":131,"doc_module":4,"doc_module_name":46,"category_name":132,"show_sort_weight":131,"slug":133},10,"Lifestyle","lifestyle",{"id":135,"doc_module":4,"doc_module_name":46,"category_name":136,"show_sort_weight":106,"slug":137},19,"General","general"]