[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436400-105":59,"doc-detail-436400-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","to-do-one-and-to-get-more-part-i-diabetes-and-bone","To do one and to get more - Part I - Diabetes and bone","","Type 2 diabetes mellitus is a chronic metabolic disorder marked by hyperglycemia and insulin resistance, and its standard management combines lifestyle change, medications, and continuous glucose monitoring. Diabetes often involves additional morbidities, yet musculoskeletal complications are frequently overlooked compared with other organ systems. The review links diabetes pathology with osteoporosis, suggesting antidiabetic agents may support glucose control and potentially protect bone health, although evidence for preventing osteoporosis and fractures remains inconclusive.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/to-do-one-and-to-get-more-part-i-diabetes-and-bone/436400/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/to-do-one-and-to-get-more-part-i-diabetes-and-bone/436400.png","ImageObject",300,407,{"name":92,"@type":93},"\tJames","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main focus of the article’s Part I topic?","Question",{"text":113,"@type":114},"It focuses on the relationship between diabetes and bone health, especially how antidiabetic strategies might influence osteoporosis and fracture risk.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which treatment approaches are discussed for diabetes management?",{"text":118,"@type":114},"The article describes lifestyle modification, pharmacological therapy using antidiabetic agents, and continuous glucose monitoring as key treatment strategies.",{"name":120,"@type":111,"acceptedAnswer":121},"Does the review find strong evidence that antidiabetic agents prevent osteoporosis and fractures?",{"text":122,"@type":114},"The review reports a positive correlation between diabetes and osteoporosis or fracture, but concludes that the effectiveness of antidiabetic agents for preventing osteoporosis and reducing fractures is inconclusive.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},436400,1790741661,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","J Chin MedAssoc  \nReview ARticle  \nTo do one and to get more: Part I. Diabetes and bone  \nWen-Ling Leea,b,c, Peng-Hui Wangb,d,e,f,* , Szu-Ting Yangb,d, Chia-Hao Liub,d, Wen-Hsun Changd,g, Fa-Kung Leeh  \naDepartment of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan, ROC; bInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; cDepartment of Nursing, Oriental Institute of Technology, New Taipei City, Taiwan, ROC; dDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; eDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC; fFemale Cancer Foundation, Taipei, Taiwan, ROC; gDepartment of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; hDepartment of Obstetrics and Gynecology, Cathy General Hospital, Taipei, Taiwan, ROC  \nAbstract: Type 2 diabetes mellitus (T2DM), is a chronic metabolic disease, characterized by the presence of hyperglycemia and insulin resistance. The key treatment strategies for T2DM include modification of lifestyle, medications, and continuous glucose monitoring. DM patients often have DM-associated morbidities and comorbidities; however, disorders of musculoskeletal system are often neglected, compared to other major systems in DM patients. Based on sharing similar pathophysiology of DM and osteoporosis, it is supposed that the use of antidiabetic agents (ADAs) may not only provide the lowering glucose level effect and the maintenance of the sugar homeostasis to directly delay the tissue damage secondary to hyperglycemia but also offer the benefits, such as the prevention of developing osteoporosis and fractures. Based on the current review, evidence shows the positive correlation between DM and osteoporosis or fracture, but the effectiveness of using ADA in the prevention of osteoporosis and subsequent reduction of fracture seems to be inconclusive. Although the benefits of ADA on bone health are uncertain, the potential value of “To do one and to get more” therapeutic strategy should be always persuaded. At least, one of the key treatment strategies as an establishment of healthy lifestyle may work, because it improves the status of insulin resistance and subsequently helps DM control, prevents the DM-related micro-and macrovascular injury, and possibly strengthens the general performance of musculoskeletal system. With stronger musculoskeletal system support, the risk of “fall” may be decreased, because it is associated with fracture. Although the ADA available in the market does not satisfy the policy of “To do one and to get more” yet, we are looking forward to seeing the continuously advanced technology of drug development on diabetic control, and hope to see their extra-sugar–lowering effects.  \nKeywords: Antidiabetic agents; Bone health; Diabetes mellitus (DM); Extra-glycemic effects  \n1. INTRODUCTION  \nDiabetes mellitus (DM), including type 1 DM (T1DM) and type 2 DM (T2DM), is a common but complex disease, associated with lots of comorbidities and a leading cause of mortality.1–8 Risk factors associated with developing DM, especially T2DM accounting for >90% of all cases of DM worldwide, include elderly population,9–11 family history (multiple genes),11–18 overweight,3,4,17–21 obesity,3,4,17–21 pregnancy, such as the development of gestational DM,21–24 dietary (calories intake, fibers,  \n* Address correspondence. Dr. Peng-Hui Wang, Department of Obstetricsand Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail address: phwang@vghtpe.gov.tw](ROC. E-mail address: phwang@vghtpe.gov.tw);  \n[pongpongwang@gmail.com](pongpongwang@gmail.com) (P.-H. Wang).  \nConflicts of interest: Dr. Peng-Hui Wang, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article. The other authors declare that they have no conflicts of interest relat","cbCaiv43Y08NbBzF","https://ap.wps.com/l/cbCaiv43Y08NbBzF","pdf",327582,"English","# Introduction\n## Diabetes as a complex chronic disease\n# Treatment strategy overview\n## Lifestyle modification\n## Pharmacological therapy and monitoring\n# Diabetes, bone health, and osteoporosis\n## Proposed benefits of antidiabetic agents\n## Evidence status and remaining uncertainty","[{\"question\":\"What is the main focus of the article’s Part I topic?\",\"answer\":\"It focuses on the relationship between diabetes and bone health, especially how antidiabetic strategies might influence osteoporosis and fracture risk.\"},{\"question\":\"Which treatment approaches are discussed for diabetes management?\",\"answer\":\"The article describes lifestyle modification, pharmacological therapy using antidiabetic agents, and continuous glucose monitoring as key treatment strategies.\"},{\"question\":\"Does the review find strong evidence that antidiabetic agents prevent osteoporosis and fractures?\",\"answer\":\"The review reports a positive correlation between diabetes and osteoporosis or fracture, but concludes that the effectiveness of antidiabetic agents for preventing osteoporosis and reducing fractures is inconclusive.\"}]","To do one and to get more - Part I - Diabetes and bone | PDF",1790677856,18]