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An integrated analysis combining Single-Cell RNA-Sequencing and TCGA data evaluates TNFSF10 as a prognostic and immunotherapy-related biomarker. Aberrant TNFSF10 expression associates with survival outcomes, and TNFSF10 silencing suppresses TGCT cell proliferation, migration, and invasion. TNFSF10 also correlates with tumor microenvironment components, supporting its value for targeted therapy and personalized treatment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tnfsf10-a-promising-prognostic-biomarker-and-therapeutic-target-for-immunotherapy-in-testicular-germ-cell-tumors/351687/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tnfsf10-a-promising-prognostic-biomarker-and-therapeutic-target-for-immunotherapy-in-testicular-germ-cell-tumors/351687.png","ImageObject",300,407,{"name":92,"@type":93},"Terk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are biomarkers needed for testicular germ cell tumors in this research?","Question",{"text":112,"@type":113},"The study highlights poor prognosis and the absence of reliable biomarkers for patient stratification and diagnosis as major challenges.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was TNFSF10 evaluated as a biomarker?",{"text":117,"@type":113},"The authors used an integrated analysis of Single-Cell RNA-Sequencing data and TCGA data to assess TNFSF10 for prognosis and immunotherapy in TGCTs.",{"name":119,"@type":110,"acceptedAnswer":120},"What effects did silencing TNFSF10 have on TGCT cells?",{"text":121,"@type":113},"TNFSF10 silencing inhibited TGCT cell proliferation, migration, and invasion, indicating a role in tumor progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},351687,1790196310,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099525198933,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","TYPE Original Research PUBLISHED 28 April 2026  \nDOI 10.3389/fimmu.2026.1761075  \nOPEN ACCESS  \nEDITED BY  \nQiang Tang,  \nZhejiang University, China  \nREVIEWED BY  \nXiangyang Yao,  \nShenzhen Second People ’s Hospital, China  \nShoukai Yu,  \nShanghai Jiao Tong University School of Medicine, China  \n*CORRESPONDENCE  \nShusheng Zhang  \n[zhangshusheng1972@yeah.net](zhangshusheng1972@yeah.net)[ ](zhangshusheng1972@yeah.net)Kongrong Xu  \n[xxylyx123@sina.com](xxylyx123@sina.com)[ ](xxylyx123@sina.com)Lei Xue  \n [xuelei@hnca.org.cn](xuelei@hnca.org.cn)  \nRECEIVED 05 December 2025  \nREVISED 18 March 2026  \nACCEPTED 30 March 2026  \nPUBLISHED 28 April 2026  \nCITATION  \nLiu G, Du L, Lv S, Liu Z, Cao J, Fan L, Zhang S, Xu K and Xue L (2026)  \nTNFSF10: a promising prognostic biomarker and therapeutic target for  \nimmunotherapy in testicular germ cell tumors.  \nFront. Immunol. 17:1761075 .  \ndoi: 10.3389/fimmu.2026.1761075  \nCOPYRIGHT  \n© 2026 Liu, Du, Lv, Liu, Cao, Fan, Zhang, Xu and Xue. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nTNFSF10: a promising prognostic biomarker and therapeutic target for immunotherapy in testicular germ cell tumors  \nGuangmin Liu 1,2,3, Lin Du 4, Shanshan Lv 4, Zhizhong Liu 1,2, Jian Cao 5, Liqing Fan 2,4, Shusheng Zhang 6*, Kongrong Xu 7* and Lei Xue 1*  \n1 Department of Pathology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China, 2 National Health Commission Key Laboratory of Human Stem Cell and Reproductive Engineering, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha, China, 3 Department of Laboratory Medicine, Dongying People’s Hospital, Dongying, China, 4Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha, China, 5 Department of Urology, the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China, 6The First Hospital of Changsha, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, China, 7 Reproductive Medicine Center, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, China  \nBackground: Testicular germ cell tumors (TGCTs) are malignant neoplasms with a poor prognosis, and the absence of reliable biomarkers for patient stratification and diagnosis presents a significant challenge.  \nMethods: We employed an integrated analysis of Single-Cell RNA-Sequencing and TCGA data to evaluate TNFSF10 as a potential biomarker for prognosis and immunotherapy in TGCTs.  \nResults: Our findings revealed that aberrant TNFSF10 expression was significantly associated with patient survival outcomes. Silencing TNFSF10 inhibited the proliferation, migration, and invasion of TGCT cells, highlighting its role in tumor progression. Moreover, TNFSF10 expression was closely correlated with various components of the tumor microenvironment, suggesting its involvement in both the biological behavior of TGCTs and their response to treatment. Conclusion: TNFSF10 emerges as a promising diagnostic and prognostic biomarker for stratification and targeted therapy in TGCTs, offering new prospects for personalized treatment strategies.  \nKEYWORDS  \nimmune cell infiltration, immunotherapy, prognostic marker, testicular germ cell tumor, TNFSF10  \n1 Introduction  \nTGCTs are a broad category of tumors originating from the germinal epithelia of seminiferous tubules in the testes. The global incidence of TGCTs has gradual","cbCaijbSGNRbGuhY","https://ap.wps.com/l/cbCaijbSGNRbGuhY","pdf",45656028,13,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Introduction\n## Clinical treatment and unmet needs\n## Role of molecular and single-cell analyses","[{\"question\":\"Why are biomarkers needed for testicular germ cell tumors in this research?\",\"answer\":\"The study highlights poor prognosis and the absence of reliable biomarkers for patient stratification and diagnosis as major challenges.\"},{\"question\":\"How was TNFSF10 evaluated as a biomarker?\",\"answer\":\"The authors used an integrated analysis of Single-Cell RNA-Sequencing data and TCGA data to assess TNFSF10 for prognosis and immunotherapy in TGCTs.\"},{\"question\":\"What effects did silencing TNFSF10 have on TGCT cells?\",\"answer\":\"TNFSF10 silencing inhibited TGCT cell proliferation, migration, and invasion, indicating a role in tumor progression.\"}]","TNFSF10 - a promising prognostic biomarker and therapeutic target for immunotherapy in testicular germ cell tumors | PDF",1790095328,33]