[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-377923-105":59,"doc-detail-377923-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tmem33-as-a-prognostic-biomarker-of-cervical-cancer-and-its-correlation-with-immune-infiltration","TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration","","Cervical cancer remains a major cause of morbidity and mortality worldwide, and reliable prognostic biomarkers linked to the tumor microenvironment are urgently needed. This research evaluates transmembrane protein 33 (TMEM33) as a prognostic biomarker in cervical cancer and examines its association with immune infiltration. Tumor specimens show higher TMEM33 expression than non-tumor tissues, and elevated TMEM33 predicts worse overall and disease-free survival. Multivariate analyses confirm independent prognostic value. TMEM33 levels inversely correlate with multiple immune cell subsets, and TMEM33 knockdown suppresses cancer cell proliferation and invasion.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tmem33-as-a-prognostic-biomarker-of-cervical-cancer-and-its-correlation-with-immune-infiltration/377923/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tmem33-as-a-prognostic-biomarker-of-cervical-cancer-and-its-correlation-with-immune-infiltration/377923.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is TMEM33’s role in cervical cancer prognosis?","Question",{"text":112,"@type":113},"Higher TMEM33 expression in cervical cancer is associated with worse overall survival and disease-free survival. Multivariate analysis indicates TMEM33 is an independent predictor of prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does TMEM33 relate to immune infiltration in the tumor microenvironment?",{"text":117,"@type":113},"TMEM33 expression shows a negative correlation with several immune cell types, including resting dendritic cells and resting mast cells, plasma cells, CD8 T cells, regulatory T cells, and related subsets.",{"name":119,"@type":110,"acceptedAnswer":120},"What experimental evidence supports TMEM33 as a functional biomarker?",{"text":121,"@type":113},"The study confirms TMEM33 overexpression in cervical cancer cells. TMEM33 knockdown significantly suppresses proliferation and invasion of cervical cancer cells.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377923,1790452551,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","Hindawi  \nMediators ofInflammation  \nVolume 2023, Article ID 5542181, 12 pages [https://doi.org/10.1155/2023/5542181](https://doi.org/10.1155/2023/5542181)  \nResearch Article  \nTMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration  \nHui Zhang, Jun Wang, Ji Yang, Qingwen He, Sanli Guan, Minxia Qiao, Jian Zhao, and Xiu Wang   \nDepartment of Ultrasound, Xi ’an People ’s Hospital (Xi ’an Fourth Hospital), Xi ’an, China  \nCorrespondence should be addressed to Xiu Wang; [3137119239@qq.com](3137119239@qq.com)  \nReceived 16 January 2023; Revised 12 April 2023; Accepted 15 May 2023; Published 27 May 2023  \nAcademic Editor: Jinghua Pan  \nCopyright © 2023 Hui Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nIn women all over the world, cervical cancer (CC) ranks as the fourth most common form of cancer to be diagnosed. It was previously reported that transmembrane protein 33(TMEM33) could report a poor prognosis in several cancers. The current study is aimed at investigating the potential prognostic value of TMEM33 and its relevance to the tumor microenvironment in CC in a comprehensive manner. In this study, CC specimens presented noticeably higher TMEM33 expression level in comparison to nontumor specimens. In pan-cancer assays, it was found that TMEM33 was present at a high level in many different kinds of tumors. We found that patients with CC patients who had a high TMEM33 expression presented worse overall survival (OS) and disease-free survival (DFS) relative to patients who had a low TMEM33 expression. According to the results of a multivariate analysis, a high level of TMEM33 expression can significantly and independently predict the prognosis of CC. The levels of TMEM33 were found to have a negative correlation with resting dendritic cells, resting mast cells, plasma cells, T cells CD8, T cells regulatory, and regulatory T cells. Finally, we confirmed that TMEM33 was overexpressed in CC cells, and its knockdown distinctly suppressed the proliferation and invasion of CC cells. Overall, we provided evidences that TMEM33 could be used as a potential biomarker to assess the prognosis and the level of immune infiltration in CC.  \n1. Introduction  \nCervical cancer (CC) is a representative disease and the third leading cause of death related to cancers among females [1] . In 2018, there were about 570,000 newly diagnosed CC cases worldwide, leading to 311,000 death cases among females [2] . It is well known that infection with the human papilloma virus (HPV) is a common cause of the carcinogenesis of CC in populations with high risks [3, 4] . However, approximately 90% of CC developed in low- and middleincome countries lack screening and HPV vaccination [5] . Patients diagnosed with cervical cancer typically undergo one of two treatment modalities, either surgery or a chemotherapy-radiotherapy combination [6, 7] . The cancer, on the other hand, is almost certainly incurable for the patient. There is a high risk that cervical cancer will progress from an early stage to a more advanced stage if it has not been treated [8, 9] . As a result, diagnosis and treatment at  \nan early stage are extremely important. Future researches are suggested to understand the processes leading to CC development and to locate novel biomarkers capable of aiding in the early diagnosis and treatment of the disease.  \nGrowing evidences suggest that both the intrinsic characteristics exhibited by the tumor cells and components in the tumor microenvironment (TME) can determine the cancer malignancy degree [10] . These components include endothelial cells, immune cells, inflammatory mediators, mesenchymal cells, and extracellular matrix molecules [11] . There is an increasing body of evidence suggesting that the characteristics exhibited by tumor-infi","cbCaimlNQlPS7BoK","https://ap.wps.com/l/cbCaimlNQlPS7BoK","pdf",4113029,12,"English","# Introduction\n# Mediators of Inflammation\n# Materials and Methods","[{\"question\":\"What is TMEM33’s role in cervical cancer prognosis?\",\"answer\":\"Higher TMEM33 expression in cervical cancer is associated with worse overall survival and disease-free survival. Multivariate analysis indicates TMEM33 is an independent predictor of prognosis.\"},{\"question\":\"How does TMEM33 relate to immune infiltration in the tumor microenvironment?\",\"answer\":\"TMEM33 expression shows a negative correlation with several immune cell types, including resting dendritic cells and resting mast cells, plasma cells, CD8 T cells, regulatory T cells, and related subsets.\"},{\"question\":\"What experimental evidence supports TMEM33 as a functional biomarker?\",\"answer\":\"The study confirms TMEM33 overexpression in cervical cancer cells. TMEM33 knockdown significantly suppresses proliferation and invasion of cervical cancer cells.\"}]","TMEM33 as a Prognostic Biomarker of Cervical Cancer and Its Correlation with Immune Infiltration | PDF",1790227662]