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Results show TMEM207 presence beyond digestive tissues, including sebaceous gland bulge regions and hair roots, alongside reduced ABCB1 and MIB-1 expression. Immunoprecipitation and staining indicate TMEM207 associates with YAP and reduces nuclear YAP localization.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/tmem207-mediated-the-impairment-of-skin-regeneration-through-yap-sequestration-in-an-allergic-contact-dermatitis-model-research-findings/415719/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/tmem207-mediated-the-impairment-of-skin-regeneration-through-yap-sequestration-in-an-allergic-contact-dermatitis-model-research-findings/415719.png","ImageObject",300,407,{"name":42,"@type":43},"นรินทร์","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main aim of the study regarding allergic contact dermatitis?","Question",{"text":63,"@type":64},"The study aimed to determine the importance of YAP regulation in allergic contact dermatitis through the lens of wound healing and regeneration.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did the researchers investigate TMEM207 in relation to YAP?",{"text":68,"@type":64},"They assessed TMEM207 expression and pathological characteristics, then used immunoprecipitation to confirm TMEM207 binding to YAP and immunohistochemical staining to evaluate YAP nuclear localization.",{"name":70,"@type":61,"acceptedAnswer":71},"What key findings link TMEM207 to impaired skin regeneration?",{"text":72,"@type":64},"Abnormal TMEM207 expression was associated with reduced skin regeneration capacity via YAP, coinciding with decreased ABCB1 in sebaceous glands and diminished MIB-1 in the epidermis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},415719,1791293200,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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(2026) 102409  \nContents lists available at ScienceDirect  \nBiochemistry and Biophysics Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/bbrep)[ www.elsevier.com/locate/bbrep](homepage: www.elsevier.com/locate/bbrep)  \n| TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model\u003Cbr>*\u003Cbr>Shusuke Nomura, Yusuke Kito , Chiemi Saigo, Tamotsu Takeuchi\u003Cbr>Department of Pathology and Translational Research, Gifu University Graduate School of Medicine, Yanagido 1-1, Gifu, 501-1194, Japan |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords: TMEM207 YAP\u003Cbr>Allergic contact dermatitis |  | Aim: The Yes-associated protein (YAP) family of transcriptional coactivators has emerged as a potent promoter of cell proliferation in many types of stem/progenitor cells and cancers. Skin is a squamous epithelium that is continuously regenerated by stem/progenitor cells in the basal layer and is capable of wound healing, and YAP also plays an important role in maintaining skin homeostasis and cellular proliferation. Therefore, we focused on YAP and investigated the importance of YAP regulation in allergic contact dermatitis from the perspective of wound healing and regeneration.\u003Cbr>Methods: We investigated the expression and pathological characteristics of Transmembrane protein 207 (TMEM207), focusing on YAP-mediated regulation in atopic models, as abnormal TMEM207 expression may cause various functional abnormalities or regulate the function of YAP.\u003Cbr>Results: TMEM207 was detected not only in the stomach and large intestine but also in the bulge region of the sebaceous glands and hair roots in mice expressing TMEM207. In addition, ATP binding cassette subfamily B member 1 (ABCB1) expression decreased in the sebaceous glands, and MIB E3 Ubiquitin Protein Ligase 1 (MIB-1) expression diminished in the epidermis. Furthermore, although we were unable to confirm the binding of TMEM207 to NEDD4, we confirmed the binding of TMEM207 to the Yes1-associated transcription factor (YAP) by immunoprecipitation, and a decrease in the nuclear localization of YAP was observed by immunohistochemical staining.\u003Cbr>Conclusion: Our findings indicate that abnormal expression of TMEM207 is involved in the decline of skin regeneration capacity through YAP, leading to the aggravation of Allergic contact dermatitis. |\n\n1. Introduction  \nThe skin, which covers the entire body, has a “barrier function” that retains moisture, prevents the intrusion of foreign substances, such as harmful microorganisms, and plays an important role in maintaining homeostasis of the body [1]. Normal skin has a stratum corneum on its surface, covered by a sebum film. Sebum is a lipid secreted by the sebaceous glands, and the stratum corneum and sebum prevent the intrusion of irritants and allergens. If the moisture content of the skin or sebaceous glands decreases, the skin barrier function decreases, leading to dryness and the development of dermatitis, such as Allergic contact dermatitis and psoriasis [2]. Allergic contact dermatitis (ACD) is an eczematous disease caused by exposure to an allergen and a delayed type IV hypersensitivity reaction [3]. It affects one in five people and can affect anyone, regardless of age [4]. Allergens come from everyday use in the workplace and in daily life and include ingredients in cosmetics,  \nchemicals, and pharmaceuticals [5]. Symptoms of ACD are diverse, including erythema, papules, vesicles, edema, and pruritus [5]. Patients with ACD often experience long-term, chronic pruritus, which significantly impacts their quality of life [6]. To date, various treatments have been used to treat ACD, including topical medications such as emollients and calcineurin inhibitors, and systemic immunosuppressants such as corticosteroids and methotrexate [7]. However, many drugs are difficult to use long-term due to side effects, m","cbCaisDGDzDXFz0P","https://ap.wps.com/l/cbCaisDGDzDXFz0P","pdf",7335244,"English","# Aim\n# Methods\n# Results\n# Conclusion\n# 1. Introduction\n# 2. Materials and methods\n## 2.1 Animals\n## 2.2 Generation of the C57BL/6-Tg (ITF-TMEM207) mouse line","[{\"question\":\"What was the main aim of the study regarding allergic contact dermatitis?\",\"answer\":\"The study aimed to determine the importance of YAP regulation in allergic contact dermatitis through the lens of wound healing and regeneration.\"},{\"question\":\"How did the researchers investigate TMEM207 in relation to YAP?\",\"answer\":\"They assessed TMEM207 expression and pathological characteristics, then used immunoprecipitation to confirm TMEM207 binding to YAP and immunohistochemical staining to evaluate YAP nuclear localization.\"},{\"question\":\"What key findings link TMEM207 to impaired skin regeneration?\",\"answer\":\"Abnormal TMEM207 expression was associated with reduced skin regeneration capacity via YAP, coinciding with decreased ABCB1 in sebaceous glands and diminished MIB-1 in the epidermis.\"}]","TMEM207-mediated the impairment of skin regeneration through YAP sequestration in an allergic contact dermatitis model - Research findings | PDF",1790602561]