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Methods: secondary analysis of a prior clinical trial; HFUS measured dynamic tissue perfusion at multiple recession defects over 6 months (baseline, 2 weeks, 3 months, 6 months), and gingival crevicular fluid biomarkers were quantified. Results: groups showed similar perfusion trajectories over most of 6 months; at 2 weeks rhPDGF sites had higher perfusion measures and early values correlated with final root coverage outcomes. Conclusions: HFUS enabled detailed perfusion assessment across surgical regions, and early graft/flap perfusion predicted clinical outcomes.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tissue-perfusion-and-biomarkers-assessment-following-root-coverage-procedures/456119/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tissue-perfusion-and-biomarkers-assessment-following-root-coverage-procedures/456119.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of the study?","Question",{"text":112,"@type":113},"To evaluate how tissue perfusion and wound-healing biomarker levels change after root coverage procedures when CCMX is used with either placebo or rhPDGF.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were tissue perfusion changes measured over time?",{"text":117,"@type":113},"High frequency Doppler ultrasonography provided dynamic tissue perfusion measurements at baseline, 2 weeks, 3 months, and 6 months at predefined sites and regions.",{"name":119,"@type":110,"acceptedAnswer":120},"What differences were observed between the rhPDGF and placebo groups?",{"text":121,"@type":113},"During most of the 6 months the perfusion changes were similar, but at the 2-week timepoint the rhPDGF group showed significantly higher perfusion relief intensity, perfused area, and blood flow intensity in graft-related regions.",{"name":123,"@type":110,"acceptedAnswer":124},"Do early perfusion parameters relate to later clinical outcomes?",{"text":125,"@type":113},"Yes. At 2 weeks, specific perfusion measures at the graft and flap levels correlated with final mean and complete root coverage, and graft perfusion parameters also correlated with volume gain at 6 months.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},456119,1791559135,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Journal of Periodontal Research  \nCLINICAL RESEARCH  OPEN ACCESS   \nTissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures  \nLorenzo Tavelli1,2,3,4  | Tu Nguyen1 | Maria Vera Rodriguez2,5 | Leonardo Mancini4,6  | William V. Giannobile1  | Shayan Barootchi1,2,4   \n1Division of Periodontology, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA | 2Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA | 3School of Dentistry, Universidad Catolica de Santiago de Guayaquil (UCSG), Guayaquil, Ecuador | 4Center for Clinical Research and Evidence Synthesis in Oral TissuE  \nRegeneratION (CRITERION), Boston, Massachusetts, USA | 5Postgraduate Periodontics, Division of Periodontics, Columbia University College of Dental Medicine, New York City, New York, USA | 6Clinic of Reconstructive Dentistry, Centre of Dental Medicine, University of Zurich, Zurich, Switzerland Correspondence: Lorenzo Tavelli ([lorenzo_tavelli@hsdm.harvard.edu](lorenzo_tavelli@hsdm.harvard.edu))  \nReceived: 16 September 2024 | Revised: 28 November 2024 | Accepted: 29 November 2024  \nFunding: The study was supported by a grant from Delta Dental Foundation (AWD010089) .  \nKeywords: blood flow | clinical trial | collagen matrix | gingival recession | growth factor | ultrasonography  \nABSTRACT  \nAim: To assess tissue perfusion changes and wound healing biomarker levels after root coverage procedures with coronally advanced flap in combination with the cross-linked xenogeneic collagen matrix (CCMX), loaded either with a placebo or recombinant human platelet-derived growth factor-BB (rhPDGF) .  \nMethods: This study was designed as a secondary analysis from a previously published clinical trial, and it assessed the tissue perfusion changes over 6 months around multiple gingival recession defects, treated with either with CCMX alone (control) or with CCMX + rhPDGF (test). High frequency Doppler ultrasonography (HFUS) scans were obtained at sites of interest at baseline, 2 weeks, 3 months, and 6 months after surgery. Dynamic tissue perfusion measurements (DTPMs) were performed at the midfacial, interproximal, and transverse aspects of the teeth by an operator, blinded to treatment allocation, using a software package. The expression of different wound healing biomarkers from the gingival crevicular fluid was also assessed.  \nResults: The regression analyses showed similar tissue perfusion changes between the two groups throughout the majority of the 6 months. DTPMs at 2 weeks showed the test group to have significantly higher perfusion relief intensity (pRI, p\u003C 0.001), mean perfused area (pA, p\u003C 0.001), mean blood flow intensity (FImean, p = 0.021), and total blood flow intensity (FItot, p = 0.021) at the graft region of interest (ROI) compared to control sites. The test sites also exhibited significantly greater pA (p = 0.033) and blood flow intensity “blue”(FIblue, meaning flow away from the transducer, p = 0.035) at the level of the flap compared to the control sites. At 2 weeks, FIblue of the graft was directly correlated with the final mean root coverage (p = 0.008) and complete root coverage (p = 0.003). FImean and FItot of the graft exhibited a direct correlation with volume gain at 6 months (p = 0.031 for both parameters). The final GT gain was correlated to the early DTPMs (pA and FIblue) of the graft and the flap. The two groups exhibited different expressions of IL-1β, PDFG-BB, and VEGF over 3 months, with the 1-week levels of PDGF-BB that were associated with time to recovery. Conclusions: HFUS allowed exquisite assessment of tissue perfusion occurring at the entire surgical reconstructive regions and also within the flap and the graft. Sites treated with CCMX + rhPDGF exhibited higher DTPMs, primarily within the graft and flap ROIs at the 2-week timepoint compared to sites augmented with CCMX + saline. Early DTPMs at the ","cbCaiaP1G1d6EEKA","https://ap.wps.com/l/cbCaiaP1G1d6EEKA","pdf",6684730,15,"English","# Abstract\n## Aim\n## Methods\n## Results\n## Conclusions\n# Summary\n## Background\n## Added value of this study\n## Clinical implications\n# Introduction","[{\"question\":\"What is the main purpose of the study?\",\"answer\":\"To evaluate how tissue perfusion and wound-healing biomarker levels change after root coverage procedures when CCMX is used with either placebo or rhPDGF.\"},{\"question\":\"How were tissue perfusion changes measured over time?\",\"answer\":\"High frequency Doppler ultrasonography provided dynamic tissue perfusion measurements at baseline, 2 weeks, 3 months, and 6 months at predefined sites and regions.\"},{\"question\":\"What differences were observed between the rhPDGF and placebo groups?\",\"answer\":\"During most of the 6 months the perfusion changes were similar, but at the 2-week timepoint the rhPDGF group showed significantly higher perfusion relief intensity, perfused area, and blood flow intensity in graft-related regions.\"},{\"question\":\"Do early perfusion parameters relate to later clinical outcomes?\",\"answer\":\"Yes. At 2 weeks, specific perfusion measures at the graft and flap levels correlated with final mean and complete root coverage, and graft perfusion parameters also correlated with volume gain at 6 months.\"}]","Tissue Perfusion and Biomarkers Assessment Following Root Coverage Procedures | PDF",1790745168,38]