[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426065-105":59,"doc-detail-426065-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","tissue-and-sex-specific-molecular-signatures-of-aging-and-the-impact-of-developmental-programming-abstract","Tissue-and Sex-Specific Molecular Signatures of Aging and the Impact of Developmental Programming - Abstract","","Aging in healthy people triggers broad molecular changes across cells, tissues, and organs that drive age-related declines in health. Genetic and lifestyle factors, including prenatal exposures, shape these processes. Using baboons in an integrated multi-omics approach, the study maps age-correlated molecular changes and finds that organs and molecular alterations emerge at different timepoints and in a sex-specific manner. Early under- or over-nutrition during pregnancy reshapes the aging trajectory, creating tissue-specific gene, protein, metabolite, and pathway differences that uniquely affect organ function.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/tissue-and-sex-specific-molecular-signatures-of-aging-and-the-impact-of-developmental-programming-abstract/426065/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/tissue-and-sex-specific-molecular-signatures-of-aging-and-the-impact-of-developmental-programming-abstract/426065.png","ImageObject",300,407,{"name":92,"@type":93},"Chumphorn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What causes the molecular changes associated with aging described in the document?","Question",{"text":112,"@type":113},"Aging induces molecular changes in cells, tissues, and organs that mediate age-related health decline. The document emphasizes that genetic and lifestyle factors, including early fetal exposures, influence these changes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the study characterize age-correlated molecular changes?",{"text":117,"@type":113},"It uses baboons and an integrated multi-omics approach to characterize age-correlated changes in organs and tissues.",{"name":119,"@type":110,"acceptedAnswer":120},"What impact does developmental programming (prenatal under- or over-nutrition) have on aging?",{"text":121,"@type":113},"Prenatal under- or over-nutrition substantially alters the aging trajectory, leading to different molecular and pathway changes and resulting in unique characteristic age-related changes in organ function.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426065,1790794167,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},2336475401981,"https://ap-avatar.wpscdn.com/avatar/22000c94efd8d5204d?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786935347598174694","450 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.1532  \nTISSUE-AND SEX-SPECIFIC MOLECULAR  \nSIGNATURES OF AGING AND THE IMPACT OF  \nDEVELOPMENTAL PROGRAMMING  \nMichael Olivier, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States  \nAging, even in healthy individuals, induces a wide range of molecular changes in cells, tissues and organs, resulting in (and mediating) the age-related decline in health. Many of these changes are influenced by both genetic and lifestyle factors, including early exposures during fetal development. We have used baboons, a non-human primate species highly similar in genetics, physiology and nutrition to humans, to characterize age-correlated molecular changes in organs and tissues using in integrated multi-omics approach. We have demonstrated that different organs show early age-related changes at different timepoints, and in a sex-specific manner, highlighting differences in aging and age-related changes to molecular and cellular functions. Also, early molecular changes are tissue-specific, with different genes, proteins, metabolites and pathways affected. Examining the adult offspring born to mothers that are either under-nourished or over-nourished during pregnancy, we also have evidence that these early exposures substantially alter the aging trajectory, lead to different molecular and pathway changes on the cellular level, and result in unique characteristic age-related changes in organ function. This suggests that developmental programming (the exposure in utero) not simply accelerates aging, but fundamentally alters the molecular mechanisms mediating age-related effects in these animals.","cbCaiqwKA5Q3Yb4Q","https://ap.wps.com/l/cbCaiqwKA5Q3Yb4Q","pdf",452729,"English","# Abstract\n## Study approach and multi-omics design\n## Sex- and organ-specific aging timelines\n## Tissue-specific molecular pathways\n## Prenatal nutrition and altered aging trajectories\n## Mechanistic implications for developmental programming","[{\"question\":\"What causes the molecular changes associated with aging described in the document?\",\"answer\":\"Aging induces molecular changes in cells, tissues, and organs that mediate age-related health decline. The document emphasizes that genetic and lifestyle factors, including early fetal exposures, influence these changes.\"},{\"question\":\"How does the study characterize age-correlated molecular changes?\",\"answer\":\"It uses baboons and an integrated multi-omics approach to characterize age-correlated changes in organs and tissues.\"},{\"question\":\"What impact does developmental programming (prenatal under- or over-nutrition) have on aging?\",\"answer\":\"Prenatal under- or over-nutrition substantially alters the aging trajectory, leading to different molecular and pathway changes and resulting in unique characteristic age-related changes in organ function.\"}]","Tissue-and Sex-Specific Molecular Signatures of Aging and the Impact of Developmental Programming - Abstract | PDF",1790639268]