[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-328813-105":59,"doc-detail-328813-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","timm9-as-a-prognostic-biomarker-in-multiple-cancers-and-its-associated-biological-processes-research-paper","TIMM9 as a prognostic biomarker in multiple cancers and its associated biological processes - research paper","","TIMM9 is investigated as a prognostic biomarker and mediator of key mitochondrial functions across pan-cancer. Bioinformatics, computational chemistry, and experimental analyses show that TIMM9 overexpression correlates with tumorigenesis, pathological stage progression, and metastasis. Missense mutations (notably S49L), copy number variations, and methylation alterations associate with poor outcomes. TIMM9 also links positively to cell cycle progression, mitochondrial and ribosomal function, oxidative phosphorylation, TCA cycle activity, and innate and adaptive immunity, with regulation suggested via mTOR signaling and molecular simulations identifying ITFG1 as a strong binding partner.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/timm9-as-a-prognostic-biomarker-in-multiple-cancers-and-its-associated-biological-processes-research-paper/328813/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/timm9-as-a-prognostic-biomarker-in-multiple-cancers-and-its-associated-biological-processes-research-paper/328813.png","ImageObject",300,407,{"name":92,"@type":93},"Theodore","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How does TIMM9 expression relate to cancer prognosis in pan-cancer?","Question",{"text":112,"@type":113},"Overexpression of TIMM9 is significantly associated with tumorigenesis, pathological stage progression, and metastasis, and TIMM9 genomic and methylation alterations correlate with poor prognosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which TIMM9 genetic and epigenetic alterations were linked to poor outcomes?",{"text":117,"@type":113},"Missense mutations (especially the S49L variant), copy number variations (CNV), and methylation alterations in TIMM9 were associated with poor cancer prognosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What biological pathways and processes are TIMM9 associated with?",{"text":121,"@type":113},"TIMM9 is positively related to cell cycle progression, mitochondrial and ribosomal function, oxidative phosphorylation, TCA cycle activity, and innate and adaptive immunity, and may be regulated through cancer-related signaling such as the mTOR pathway.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328813,1790179461,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461740886,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nTIMM9 as a prognostic biomarker in multiple cancers and its associated biological processes  \nLisheng Zhang1,2, Yan Huang1,2, Yanting Yang1,2, Birong Liao1,2, Congyan Hou1, Yiqi Wang1, Huaiyu Qin1, Huixiang Zeng1, Yanli He1*, Jiangyong Gu1* & Ren Zhang1*  \nTIMM9 has been identified as a mediator of essential functions in mitochondria, but its association with pan-cancer is poorly understood. We herein employed bioinformatics, computational chemistry techniques and experiments to investigate the role of TIMM9 in pan-cancer. Our analysis revealed that overexpression of TIMM9 was significantly associated with tumorigenesis, pathological stage progression, and metastasis. Missense mutations (particularly the S49L variant), copy number variations (CNV) and methylation alterations in TIMM9 were found to be associated with poor cancer prognosis. Moreover, TIMM9 was positively related with cell cycle progression, mitochondrial and ribosomal function, oxidative phosphorylation, TCA cycle activity, innate and adaptive immunity. Additionally, we discovered that TIMM9 could be regulated by cancer-associated signaling pathways, such as the mTOR pathway. Using molecular simulations, we identified ITFG1 as the protein that has the strongest physical association with TIMM9, which show a promising structural complement.  \nKeywords Pan-cancer, Mitochondria, Metabolism reprogramming, Oxidative phosphorylation, Drug resistance  \nTumorigenesis has been demonstrated to be a complicated, metabolism-related process, including abnormalities in glycolysis and oxidative phosphorylation, which reshape the tumor microenvironment (TME)1. Mitochondria have been identified as mediators of essential metabolic and immunologic processes2,3, so investigating the association between mitochondria and tumorigenesis is likely to be meaningful.  \nTIMM9 is a molecular chaperone localized in mitochondrial intermembrane space (IMS)4. It plays an essential role in the transport of proteins that are destined for the mitochondrial inner membrane5. As a member of small TIM family6. TIMM9 has been shown to interact with TIMM107. Further studies have demonstrated that an arrangement of 3 TIMM9 and 3 TIMM10 molecules forms a heterohexamer8, which mediates the substrate specificity of the TIM22 mitochondrial import pathway9. Reportedly, overexpression of TIMM9 is associated with a negative prognosis in gastric cancer10. TIMM9 is among the genes involved in oxidative phosphorylation that have been used as signatures for predicting prognosis11. Additionally, TIMM9 is selectively localized in breast neoplasm rather than peripheral tissues12. This indicates an association between TIMM9 and tumorigenesis. However, it is necessary to conduct a comprehensive investigation of the expression variations of TIMM9 and their relationship with prognosis in pan-cancer, at various detection levels.  \nIn this study, we aimed to investigate the expression levels of TIMM9 in various types of cancer, and its correlations with prognosis, tumorigenesis, metastasis, proliferation, differentiation, tumor microenvironment (TME), drug resistance and other phenotypes. Metabolic reprogramming, including alterations in oxidative phosphorylation and glycolysis, has been extensively studied in cancer. In addition, we have analyzed TIMM9-associated signaling pathways as well as possible TIMM9 regulation strategies.  \nResults  \nTIMM9 expression is significantly elevated in cancerous tissues  \nWe used TIMER 2.0 to investigate the differential RNA expression of TIMM9 between cancer tissues and normal tissues. Our analysis revealed significant overexpression of TIMM9 in 13 different types of cancers (Fig. 1A), including CHOL, COAD, ESCA, GBM, HNSC, KICH, KIRC, LIHC, LUAD, LUSC, PRAD, READ and STAD.  \n1School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, 232 Outer Ring East Road, Guangzhou University City, Panyu ","cbCaidr74h2HoPYh","https://ap.wps.com/l/cbCaidr74h2HoPYh","pdf",12084157,21,"English","# Results\n## TIMM9 expression is significantly elevated in cancerous tissues\n## Association of TIMM9 with prognosis, tumor progression, and metastasis","[{\"question\":\"How does TIMM9 expression relate to cancer prognosis in pan-cancer?\",\"answer\":\"Overexpression of TIMM9 is significantly associated with tumorigenesis, pathological stage progression, and metastasis, and TIMM9 genomic and methylation alterations correlate with poor prognosis.\"},{\"question\":\"Which TIMM9 genetic and epigenetic alterations were linked to poor outcomes?\",\"answer\":\"Missense mutations (especially the S49L variant), copy number variations (CNV), and methylation alterations in TIMM9 were associated with poor cancer prognosis.\"},{\"question\":\"What biological pathways and processes are TIMM9 associated with?\",\"answer\":\"TIMM9 is positively related to cell cycle progression, mitochondrial and ribosomal function, oxidative phosphorylation, TCA cycle activity, and innate and adaptive immunity, and may be regulated through cancer-related signaling such as the mTOR pathway.\"}]","TIMM9 as a prognostic biomarker in multiple cancers and its associated biological processes - research paper | PDF",1789981136,53]