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Data were collected by the Cancer Registry Service of Haroldo Juaçaba Hospital/Ceará Cancer Institute over 22 years (2000–2021). Median overall survival reached 59.77, with squamous cell carcinoma dominating (88.2%). Multivariate results identify age, race, low education, tumor location, staging, and treatment as independent risk factors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/time-series-and-risk-factors-associated-with-mortality-in-women-with-cervical-cancer-from-2000-to-2021/332468/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/time-series-and-risk-factors-associated-with-mortality-in-women-with-cervical-cancer-from-2000-to-2021/332468.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main study design and data source?","Question",{"text":112,"@type":113},"The study used an observational, retrospective, cross-sectional, quantitative design. Data came from the Cancer Registry Service of Haroldo Juaçaba Hospital/Ceará Cancer Institute over 22 years.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What were the key findings about mortality time-series outcomes?",{"text":117,"@type":113},"The sample included 9,096 women, with a mean age of 51.4 years and median overall survival of 59.77. Squamous cell carcinoma was the most frequent histological type (88.2%).",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors were independently associated with higher death risk?",{"text":121,"@type":113},"Multivariate analysis showed independent risk associations for age, race, low level of education, tumor location, staging, and treatment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332468,1791156480,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Gynecologic Oncology Reports 55 (2024) 101490  \nContents lists available at ScienceDirect  \nGynecologic Oncology Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/gynor)[ www.elsevier.com/locate/gynor](homepage: www.elsevier.com/locate/gynor)  \n| Time series and risk factors associated with mortality in women with cervical cancer from 2000 to 2021\u003Cbr>Talita de Oliveira Lima , Jos´e Erialdo da Silva Junior , Giulianna Aparecida Vieira Barreto , Max Wellington S´atiro Justino , Maria Lia Coutinho Carvalho , Marcelo Gurgel Carlos da Silva , Daniele Alves Ferreira , Lúcio Fl´avio Gonzaga Silva , Paulo Goberlˆanio de Barros Silva *\u003Cbr>Oncology Department in Cancer Institute of Cear´a, Brazil |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Cervical Neoplasms Womens Health Mortality |  | Introduction: Cervical cancer is a significant public health problem worldwide. The development of cervical neoplasms is associated with persistent infection by oncogenic subtypes of the HPV virus, which are responsible for around 70% of cervical cancers.A study carried out in Brazil between 2002 and 2021 recorded 133,429 deaths from cervical cancer..\u003Cbr>Methodology: An observational, retrospective, cross-sectional, quantitative study was carried out using data collected by the Cancer Registry Service of the Haroldo Juaçaba Hospital/Cear´a Cancer Institute (HHJ/ICC) over 22 years.\u003Cbr>Results: The sample consisted of 9096 women. The mean age was 51.4 ± 15.5, ranging from 15 to 100, with a median age of 60 years. Median overall survival was 59.77. The most frequent histological type was squamous cell carcinoma, with 8023 (88.2 %) cases. Around 25 % of patients (n = 2270) entered the service with stage 4A. The most common treatment was radiotherapy combined with chemotherapy (n = 3270, 35.9 %), followed by surgical removal (n = 1909, 21.0 %).In multivariate analysis, age (p = 0.019), race (p = 0.016), low level of education (p \u003C 0.001), tumor location, staging (p \u003C 0.001), and treatment (p = 0.011) were risk factors independently associated with a higher chance of death in the sample studied.\u003Cbr>Conclusion: The sociodemographic characteristics of mortality from cervical cancer in patients followed up at the Haroldo Juaçaba Hospital (HHJ/ICC) highlight the higher frequency of deaths in women aged over 60, indigenous and black, with low levels of education, as well as clinical variables related to tumor location, staging and type of treatment. |\n\n1. Introduction  \nCervical cancer is a significant public health problem worldwide. According to the World Health Organization (WHO), in 2020, more than 500,000 women were diagnosed, and almost 342,000 died. Approximately 80 % of cases occur in underdeveloped and developing countries due to the lack of an adequate and effective screening program (Sarmento, 2022).  \nCurrently, cervical cancer is considered to be eradicable through vaccination against the most prevalent types of oncogenic HPV and the screening and treatment of precursor lesions. Lesions are detected by cervical cytopathology tests, which should be carried out every three years on all women who have started having sex and/or are aged 25 or  \nover (Nacional, 2023).  \nIn Brazil, it is estimated to be the third most common malignant neoplasm among women. For each year of the 2023–2025 triennium, 17,010 new cases were calculated for the country, corresponding to an estimated risk of 15.38 cases per 100,000 women. The Northeast region ranks second in incidence, with a relevance of 17.59 cases per 100,000 women (Nacional, 2023).  \nThe most common histological type is Squamous Cell Carcinoma (SCC), which accounts for approximately 75 % to 80 % of all cervical cancers, while adenocarcinoma accounts for approximately 20 %(AbuRustum, 2020 Jun).  \nThe development of cervical neoplasms is associated with persistent infection by oncogenic subtypes of the HPV (Human Papillomavirus)  \n* Corresponding author a","cbCaigYLOI0IV9D4","https://ap.wps.com/l/cbCaigYLOI0IV9D4","pdf",672494,"English","# Introduction\n## Cervical cancer as a public health problem\n## Screening, vaccination, and precursor lesion management\n## Epidemiology and histological types\n## HPV, immunity, and additional risk determinants\n## Staging systems and diagnostic approaches\n# Methodology\n# Results\n# Conclusion","[{\"question\":\"What was the main study design and data source?\",\"answer\":\"The study used an observational, retrospective, cross-sectional, quantitative design. Data came from the Cancer Registry Service of Haroldo Juaçaba Hospital/Ceará Cancer Institute over 22 years.\"},{\"question\":\"What were the key findings about mortality time-series outcomes?\",\"answer\":\"The sample included 9,096 women, with a mean age of 51.4 years and median overall survival of 59.77. Squamous cell carcinoma was the most frequent histological type (88.2%).\"},{\"question\":\"Which factors were independently associated with higher death risk?\",\"answer\":\"Multivariate analysis showed independent risk associations for age, race, low level of education, tumor location, staging, and treatment.\"}]","Time series and risk factors associated with mortality in women with cervical cancer from 2000 to 2021 | PDF",1789998332,13]