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Uptake is normalized for current TSH stimulation and compared with a raw uptake measure, accounting for factors including urinary iodine concentration. A multicentric prospective cohort of 125 healthy patients assesses uptakeTSH1, uptakeTSH1&uic, and alternative normalizations, evaluating discrimination against functional thyroid disorders through correlation and 95% confidence intervals.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/thyroid-scintigraphy-establishing-a-clinically-useful-normal-range-for-99mtc-pertechnetate-uptake/510301/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/thyroid-scintigraphy-establishing-a-clinically-useful-normal-range-for-99mtc-pertechnetate-uptake/510301.png","ImageObject",300,407,{"name":92,"@type":93},"RuangKosong","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-10","2026-10-05",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main goal of the study on thyroid scintigraphy?","Question",{"text":113,"@type":114},"To establish a clinically useful normal range for thyroid uptake derived from 99mTc-pertechnetate scans, taking variations in uptake with TSH stimulation and other factors into account.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was “normal functional thyroid status” ensured for the participants?",{"text":118,"@type":114},"By normal TSH, normal thyroid size, no thyroid antibodies, and no symptoms of thyroid functional disorders in healthy subjects.",{"name":120,"@type":111,"acceptedAnswer":121},"Which normalization improved distinction from functional thyroid disorders?",{"text":122,"@type":114},"Normalization for current TSH stimulation (uptakeTSH1) produced a clear distinction, and additional normalization for urinary iodine concentration (uptakeTSH1&uic) may further improve discriminatory power.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},510301,1791296833,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090883219,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Article published online: 2024-07-31  \nOriginal Article  \n| Thyroid scintigraphy: establishing a clinically useful normal range for 99mTc pertechnetate uptake\u003Cbr>Schilddrüsenszintigrafie: Bestimmung eines klinisch hilfreichen Normalbereichs für den 99mTc-Pertechnetat-Uptake |  |\n| --- | --- |\n| Authors\u003Cbr>Michael Grunert1, 2, Simone Agnes Schenke3, 4, Andrea Konrad1, Christina Schütze3, Stefan Förster3, 5, Burkhard Klemenz1, Alexander R. Stahl6 |  |\n| Affiliations\u003Cbr>1 Department of Nuclear Medicine, Bundeswehrkrankenhaus Ulm, Ulm, Germany\u003Cbr>2 Department of Nuclear Medicine, Ulm University Hospital, Ulm, Germany\u003Cbr>3 Klinik und Institut für Nuklearmedizin, Klinikum Bayreuth GmbH, Bayreuth, Germany\u003Cbr>4 Nuklearmedizin, Universitätsklinikum Magdeburg, Magdeburg, Germany\u003Cbr>5 Medizincampus Oberfranken, Friedrich-AlexanderUniversität Erlangen-Nürnberg, Erlangen, Germany\u003Cbr>6 Institute for Radiology and Nuclear Medicine RIZ, Augsburg, Germany\u003Cbr>Keywords\u003Cbr>thyroid scintigraphy, TSH, urinary iodine concentration, 99mTc-pertechnetate uptake\u003Cbr>received 28.3.2024\u003Cbr>accepted after revision 12.7.2024\u003Cbr>Bibliography Nuklearmedizin\u003Cbr>DOI 10.1055/a-2365-7917\u003Cbr>ISSN 0029-5566\u003Cbr>© 2024 . Thieme. All rights reserved.\u003Cbr>Georg Thieme Verlag KG, Rüdigerstraße 14, 70469 Stuttgart, Germany\u003Cbr>Correspondence Dr. Michael Grunert\u003Cbr>Department of Nuclear Medicine, Bundeswehrkrankenhaus Ulm, Ulm, Germany [michael.grunert@uni-ulm.de](michael.grunert@uni-ulm.de) | ABSTRACT\u003Cbr>Purpose This study aims to establish a normal range for the thyroid uptake derived from 99mTc pertechnetate scans. In particular, variations of uptake with TSH stimulation and other factors such as urinary iodine concentration are taken into account and compared with the calculation of a raw uptake value.\u003Cbr>Methods Clinical multicentric (center A, B and C) prospective study on 125 consecutive healthy patients undergoing thyroid scans for thyroid nodules. Normal functional thyroid status was assured by normal TSH, normal thyroid size, no thyroid antibodies and no symptoms of thyroid functional disorders. Calculations of raw Tc-uptake (uptake) and modified uptake values regarding current TSH value (uptakeTSH1 ), urinary iodine concentration (uptakeTSH 1&uic), gland volume, age, smoking status, weight and tissue thickness ventral to the thyroid were performed.\u003Cbr>Results There is a positive correlation of thyroid uptake with TSH allowing for the calculation of a normalized uptake value (uptakeTSH1) . The normal range for uptakeTSH1 compares favourable to that for raw uptake in that it yields a clear distinction from thyroid functional disorders. The additional normalization for urinary iodine concentration (uptakeTSH 1&uic) may even improve the distinctive power whereas further normalizations such as for gland volume, age and others are not warranted by this study. The 95% CI of uptakeTSH1 for sites A, A&B, and A&B&C were 0.21 %–2.06 %, 0.22 %–2.38 % and 0.24%–2 .40% .\u003Cbr>Conclusion A normal range for the thyroid uptake can be established with respect to the current TSH stimulation. This normalization (uptakeTSH1) overcomes the drawback of raw uptake by yielding a clinically useful parameter with obviously high distinctive power against functional thyroid disorders. |\n\nIntroduction  \nThyroid scintigraphy with 99mTc-pertechnetate is frequently used in patients to evaluate the functional activity of thyroid nodules found on ultrasound or in patients with abnormal thyroid function, particularly in cases with hyperthyroidism [1] . Its use in evaluating hypothyroidis m is less frequent, which is somewhat  \nsurprising given that the underlying principles of thyroid scintigraphy in hypothyroidism should parallel those in hyperthyroidism. In hyperthyroidism, a 99mTc-pertechnetate uptake of at least 1% in case of a suppressed TSH (0,1 mU/l or lower) is often considered diagnostic of relevant hyperthyroidism [2] . However, no comparable criterion exists for hypothyroidism.  \nGrunert M ","cbCaiqIMnOYjkeMi","https://ap.wps.com/l/cbCaiqIMnOYjkeMi","pdf",944272,"English","# ABSTRACT\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the main goal of the study on thyroid scintigraphy?\",\"answer\":\"To establish a clinically useful normal range for thyroid uptake derived from 99mTc-pertechnetate scans, taking variations in uptake with TSH stimulation and other factors into account.\"},{\"question\":\"How was “normal functional thyroid status” ensured for the participants?\",\"answer\":\"By normal TSH, normal thyroid size, no thyroid antibodies, and no symptoms of thyroid functional disorders in healthy subjects.\"},{\"question\":\"Which normalization improved distinction from functional thyroid disorders?\",\"answer\":\"Normalization for current TSH stimulation (uptakeTSH1) produced a clear distinction, and additional normalization for urinary iodine concentration (uptakeTSH1\\u0026uic) may further improve discriminatory power.\"}]","Thyroid scintigraphy - establishing a clinically useful normal range for 99mTc pertechnetate uptake | PDF",1791240316,25]