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It emphasizes the critical caution regarding the massive bleeding risk associated with these potent drugs, labeling them as the \"MOST powerful 1 time push drugs\" and potentially the \"MOST deadly.\" Key contraindications are clearly listed, including active bleeding, uncontrolled hypertension (180/110+), and recent surgery within two weeks, with specific emphasis on avoiding injections at all sites, including new IVs, subcutaneous, intramuscular, and arterial blood gases (ABGs). It clarifies that these medications can only be administered via a compressible site, specifically a peripheral IV, and explicitly excludes central lines. The document also provides NCLEX tips and key terms such as \"Peptic ULCER\" to aid in understanding and retention of critical information for nursing examinations. 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