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Original DFU recurrence data were collected from studies published through 2024 and pooled into a mean estimate. CLTI reintervention data were drawn from the BEST-CLI trial. Pooled 3-year DFU recurrence was 58% and CLTI reintervention was 50%, comparable to breast, prostate, colorectal, and lung cancer recurrences. Despite similar risk, DFU and CLTI are underrecognized; findings support reframing healed DFU and post-intervention CLTI as remission requiring structured surveillance and proactive management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/three-year-recurrence-in-people-with-diabetic-foot-ulcers-and-chronic-limb-threatening-ischemia-is-comparable-to-cancer/374643/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/three-year-recurrence-in-people-with-diabetic-foot-ulcers-and-chronic-limb-threatening-ischemia-is-comparable-to-cancer/374643.png","ImageObject",300,407,{"name":92,"@type":93},"Nguyễn Văn Học","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective regarding recurrence?","Question",{"text":112,"@type":113},"The study aimed to compare 3-year recurrence rates of diabetic foot ulcers and endovascular reintervention for chronic limb-threatening ischemia with recurrence rates of advanced-stage cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the DFU recurrence and CLTI reintervention rates obtained?",{"text":117,"@type":113},"DFU recurrence data were systematically collected from studies published through 2024 and pooled into a mean estimate. CLTI reintervention data were taken from the BEST-CLI trial.",{"name":119,"@type":110,"acceptedAnswer":120},"What key recurrence rates were reported after three years?",{"text":121,"@type":113},"The pooled 3-year DFU recurrence rate was 58%, and the CLTI reintervention rate was 50%.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},374643,1790555536,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},1374402739827,"https://ap-avatar.wpscdn.com/avatar/14000c97e7351f1a627?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787885694763230660","International Wound Journal  \nORIGINAL ARTICLE  OPEN ACCESS   \nThree-Year Recurrence in People With Diabetic Foot Ulcers and Chronic Limb Threatening Ischemia Is Comparable to Cancer  \nNatalie S. Armstrong1,2 | Alexandria A. Armstrong3 | Joseph L. Mills4 | Michael S. Conte5 | Tze-Woei Tan6 | Richard S. Swanson7 | David G. Armstrong6  \n1Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA | 2The National Academy of Sciences, Washington, DC,  \nUSA | 3Department of Orthopaedics, Division of Podiatric Surgery, University of Texas Health Science Center, San Antonio, USA | 4The Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA | 5Department of Surgery, University of California san Francisco, San Francisco, California, USA | 6Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery, Keck School of Medicine of USC, Los Angeles, California, USA | 7Division of Surgical Oncology, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, USA  \nCorrespondence: David G. Armstrong ([armstrong@usa.net](armstrong@usa.net))  \nReceived: 14 May 2025 | Revised: 3 July 2025 | Accepted: 4 July 2025  \nKeywords: amputation | diabetes | diabetic foot | ischemia | remission | wound healing  \nABSTRACT  \nThis study aimed to compare the 3-year recurrence rates of diabetic foot ulcers (DFU) and the rate of endovascular reintervention for chronic limb-threatening ischaemia (CLTI) to recurrence rates of advanced-stage cancers. We systematically collected original data reporting 3-year DFU recurrence from studies published through 2024 and calculated a pooled mean. These findings were compared to recurrence rates for advanced breast, prostate, colorectal, and lung cancers using contemporary sources from the National Cancer Institute and American Cancer Society. CLTI reintervention data were drawn from the BEST-CLI trial. The pooled 3-year DFU recurrence rate was 58%, while the CLTI reintervention rate was 50%—comparable to cancer recurrence rates: breast (25%–40%), prostate (30%–40%), colorectal (30%–50%), and lung (60%–80%) . Despite these comparable risks, DFU and CLTI remain underrecognized in terms of their recurrent burden on individuals, families, and health systems. The data presented here underscore the need to reframe healed DFU and post-intervention CLTI not as an endpoint but as a remission—a state requiring structured surveillance and proactive management, much like in oncology. Developing interdisciplinary survivorship care plans for individuals with DFU and CLTI, modelled on those used in cancer care, may improve communication, enhance secondary prevention, and foster more ulcer-free, hospital-free, and activity-rich days.  \n2 | Introduction  \nLower extremity complications of diabetes continue to exact a significant burden on society. Approximately one third of people with diabetes will develop a diabetic foot ulcer (DFU) in their lifetime [1, 2] . Half of these DFUs will become infected and 20% of those infections will require hospitalisation [1–5] . Ultimately, approximately 20% of DFUs end in some form of amputation [1]. While interdisciplinary teams appear to play a strong role in  \nreducing acute and long-term risk for lower extremity complications, such teams remain the exception rather than the rule at centres worldwide [1, 6] .  \nIn 2020, we summarised data comparing diabetic foot complications to cancer [7] . Since diabetic foot ulcer (DFU) recurrence takes place following a period of remission, it would stand to reason that a comparison to similarly morbid cancers would be apt. Many patients with lower extremity ulcers have  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s). International Wound Journal pub","cbCaicTgtSAZHkAy","https://ap.wps.com/l/cbCaicTgtSAZHkAy","pdf",279899,"English","# Abstract\n# Introduction\n# Methods\n# Summary","[{\"question\":\"What was the study’s main objective regarding recurrence?\",\"answer\":\"The study aimed to compare 3-year recurrence rates of diabetic foot ulcers and endovascular reintervention for chronic limb-threatening ischemia with recurrence rates of advanced-stage cancers.\"},{\"question\":\"How were the DFU recurrence and CLTI reintervention rates obtained?\",\"answer\":\"DFU recurrence data were systematically collected from studies published through 2024 and pooled into a mean estimate. CLTI reintervention data were taken from the BEST-CLI trial.\"},{\"question\":\"What key recurrence rates were reported after three years?\",\"answer\":\"The pooled 3-year DFU recurrence rate was 58%, and the CLTI reintervention rate was 50%.\"}]","Three-Year Recurrence in People With Diabetic Foot Ulcers and Chronic Limb Threatening Ischemia Is Comparable to Cancer | PDF",1790202081]